A5077774907- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Reproductive Health and Technologies
- Drug Transport and Resistance Mechanisms
- Assisted Reproductive Technology and Twin Pregnancy
- Pregnancy and preeclampsia studies
- Ovarian function and disorders
- Pregnancy and Medication Impact
- Adolescent Sexual and Reproductive Health
- Mobile Health and mHealth Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Migration, Health and Trauma
- Child Development and Digital Technology
- Racial and Ethnic Identity Research
- Immune cells in cancer
- Endometriosis Research and Treatment
- Sperm and Testicular Function
- Birth, Development, and Health
- Microfluidic and Bio-sensing Technologies
- Gynecological conditions and treatments
- Reproductive Health and Contraception
- Maternal and fetal healthcare
- Reliability and Maintenance Optimization
- Growth Hormone and Insulin-like Growth Factors
- Marine Biology and Environmental Chemistry
Charité - Universitätsmedizin Berlin
2020-2025
Freie Universität Berlin
2020-2025
Humboldt-Universität zu Berlin
2020-2025
Bedford Research Foundation
2022-2024
John Brown University
2023
Brown University
2012-2021
Health Resources and Services Administration
2020
Providence College
2013-2020
Women & Infants Hospital of Rhode Island
2013-2020
Hyundai Mobis (South Korea)
2018
The fertility of women declines sharply after age 35 and is essentially lost upon menopause at 51. ovary plays an important part in aging-associated changes women's physiology since it essential component both the reproductive endocrine systems. Several previous studies mice have shown that ovarian tissue goes through drastic over course aging exhibits signs chronic inflammation (inflammaging), which may contribute to marked decline oocyte quality aged individuals. To further examine gene...
Abstract Determining egg quality is the foremost challenge in assisted reproductive technology (ART). Although extensive advances have been made multiple areas of ART over last 40 years, oocyte assessment tools not much evolved beyond standard morphological observation. The only delivers half nuclear genetic material and all mitochondrial DNA to an embryo but also provides complete developmental support during embryonic growth. Oocyte numbers far exceed those any somatic cell, yet little...
Abstract The aging of mammalian ovary is accompanied by an increase in tissue fibrosis and heightened inflammation. Myeloid cells, including macrophages, monocytes, dendritic neutrophils, play pivotal roles shaping the ovarian microenvironment regulating inflammatory responses. However, a comprehensive understanding these cells process lacking. To bridge this knowledge gap, we utilized single-cell RNA sequencing (scRNAseq) flow cytometry analysis to functionally characterize CD45+ CD11b+...
To determine the multidrug-resistant transporter (MDR) activity in oocytes and their potential role oocyte susceptibility to chemotherapy. Experimental laboratory study. University academic center for reproductive medicine. Women with eggs retrieved intracytoplasmic sperm injection cycles adult female FVBN B6C3F1 mouse strains. Inhibition of MDR oocytes. Efflux MDRs use quantitative fluorescent dye efflux, cell death when exposed Oocytes effluxed reporters, this was significantly reduced...
The aging of mammalian ovary is accompanied by an increase in tissue fibrosis and heightened inflammation. Myeloid cells, including macrophages, monocytes, dendritic neutrophils, play pivotal roles shaping the ovarian microenvironment regulating inflammatory responses. However, a comprehensive understanding these cells process lacking. To bridge this knowledge gap, we utilized single-cell RNA sequencing (scRNAseq) flow cytometry analysis to functionally characterize CD45
To assess infertility knowledge and treatment beliefs among African American women in an urban community Atlanta, Georgia.This was a cross sectional study at safety net hospital. A convenience sample of total 158 receiving outpatient obstetrical or gynecologic care from March-April 2017 were recruited. Infertility assessed using previously applied field-tested survey the International Fertility Decision Making Study.The mean score 38.15% for subjects. Those with higher level education (p <...
Abstract Multidrug resistance transporters (MDRs) are best known for their pathological role in neoplastic evasion of chemotherapeutics and antibiotics. Here we show that MDR-1 is present the oocyte mitochondrial membrane, it protects female gamete from oxidative stress. Female mdr1a mutant mice have no significant difference ovarian follicular counts stages, nor reproductively functioning hormone levels, yet these significantly more vulnerable to gonadotoxic chemotherapy, chronically...
Multidrug resistance transporters (MDRs) are transmembrane proteins that efflux metabolites and xenobiotics. They highly conserved in sequence function bacteria eukaryotes play important roles cellular homeostasis, as well avoidance of antibiotics cancer therapies. Recent evidence also documents a critical role reproductive health protecting the ovary from environmental toxicant effects. The most understood MDRs MDR-1 (P-glycoprotein (P-gp) known ABCB1) BCRP (breast protein) both expressed...
In brief Oocyte quality remains the most important and unsolved issue in reproduction. Our data show that multidrug resistance transporters oocyte mitochondria are involved determining a mouse model. Abstract Multidrug transporter-1 (MDR-1) is transmembrane ATP-dependent effluxer present organs transport variety of xenobiotics by-products. Previous findings by our group demonstrated this transporter also mitochondrial membrane its mutation led to abnormal homeostasis. Considering importance...