A5073090059- Advanced Radiotherapy Techniques
- Medical Imaging Techniques and Applications
- Head and Neck Cancer Studies
- Radiomics and Machine Learning in Medical Imaging
- Salivary Gland Disorders and Functions
- Lung Cancer Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Oral health in cancer treatment
- Advanced Neuroimaging Techniques and Applications
- Management of metastatic bone disease
- Radiation Dose and Imaging
- Prostate Cancer Treatment and Research
- MRI in cancer diagnosis
- AI in cancer detection
- Drug Transport and Resistance Mechanisms
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Medical Image Segmentation Techniques
- Lung Cancer Treatments and Mutations
- Reproductive System and Pregnancy
- Advanced Image Processing Techniques
- Immune cells in cancer
- Brain Metastases and Treatment
- Effects of Radiation Exposure
University of British Columbia
2014-2025
Surrey Memorial Hospital
2024
BC Cancer Agency
2014-2022
Women & Infants Hospital of Rhode Island
2019-2020
Brown University
2018-2020
Providence College
2020
University of California, San Diego
2014
The fertility of women declines sharply after age 35 and is essentially lost upon menopause at 51. ovary plays an important part in aging-associated changes women's physiology since it essential component both the reproductive endocrine systems. Several previous studies mice have shown that ovarian tissue goes through drastic over course aging exhibits signs chronic inflammation (inflammaging), which may contribute to marked decline oocyte quality aged individuals. To further examine gene...
Objective. Xerostomia and radiation-induced salivary gland dysfunction remain a common side effect for head-and-neck radiotherapy patients, attempts have been made to quantify the heterogeneity of dose response within parotid glands. Prostate Specific Membrane Antigen (PSMA) ligands demonstrated high uptake in glands, which has shown correlate with functionality. Here we compare several models subregional relative importance PSMA positron emission tomography (PET) uptake. We then develop...
Abstract Purpose Left ventricle (LV) regional myocardial displacement due to cardiac motion was assessed using cardiovascular magnetic resonance (CMR) cine images establish region‐specific margins for radioablation treatments. Methods CMR breath‐hold and LV tissue contour points were analyzed 200 subjects, including controls ( n = 50) heart failure (HF) patients with preserved ejection fraction (HFpEF, 50), mid‐range (HFmrEF, reduced (HFrEF, 50). Contour divided into segments according the...
Abstract Multidrug resistance transporters (MDRs) are best known for their pathological role in neoplastic evasion of chemotherapeutics and antibiotics. Here we show that MDR-1 is present the oocyte mitochondrial membrane, it protects female gamete from oxidative stress. Female mdr1a mutant mice have no significant difference ovarian follicular counts stages, nor reproductively functioning hormone levels, yet these significantly more vulnerable to gonadotoxic chemotherapy, chronically...
Parotid glands are treated clinically as though the distribution of functional burden were homogeneous. Radiotherapy treatments planned using whole parotid mean dose to predict risk salivary dysfunction. Recent progress has identified specific non-homogeneities by demonstrating existence regional, bath-and-shower, and dose-volume effects. In this work, regional effects their impact on function quantified a non-parametric (model-free) approach. Regional have implications for clinical sparing...
The purpose was to investigate the spatial heterogeneity of prostate-specific membrane antigen (PSMA) positron emission tomography (PET) uptake within parotid glands. We aim quantify patterns in well-defined regions facilitate further investigations. Furthermore, we whether is correlated with computed (CT) texture features. Parotid glands from [18F]DCFPyL PSMA PET/CT images 30 prostate cancer patients were analyzed. Thresholding used define high-uptake regions, and statistics various...
Abstract Background Radiotherapy delivery regimens can vary between a single fraction (SF) and multiple fractions (MF) given daily for up to several weeks depending on the location of cancer or metastases. With limited evidence comparing fractionation oligometastases, there is support explore toxicity levels nearby organs at risk as primary outcome while using SF MF stereotactic ablative radiotherapy (SABR) well differences in patient-reported quality life experience. Methods This study will...
. To simultaneously deblur and supersample prostate specific membrane antigen (PSMA) positron emission tomography (PET) images using neural blind deconvolution.
. To improve intravoxel incoherent motion imaging (IVIM) magnetic resonance Imaging quality using a new image denoising technique and model-independent parameterization of the signal versus
The purpose of this investigation is to quantify the spatial heterogeneity prostate-specific membrane antigen (PSMA) positron emission tomography (PET) uptake within parotid glands. We aim patterns in well-defined regions facilitate further investigations. Furthermore, we investigate whether correlated with computed (CT) texture features.
Xerostomia is one of the most likely late toxic effects radiotherapy treatment in patients with head-and-neck cancers. Modern techniques can incorporate knowledge complication risk into plans. To this end, authors attempt to quantify regional dose-dependence salivary output loss and recovery a prospective study.Salivary was collected from undergoing for cancers at BC Cancer Agency between February 2008 May 2013. Regional (i.e., dose susceptibility) quantified using nonparametric (Spearman's...
Purpose: Exploration of historical data for regional organ dose sensitivity is limited by the effort needed to (sub-)segment large numbers contours. A system has been developed which can rapidly perform autonomous contour sub-segmentation and generic dose-volume computations, substantially reducing required exploratory analyses.
Modern inverse planning radiotherapy techniques allow for organs at risk (OARs) to evade radiation doses that they would have been subjected with earlier techniques. The extent which patient outcomes may be improved using these depends on the delineation accuracy of target volumes and OARs medical images as well clinical dose constraints applied regions interest (ROIs). recent discovery bilateral "tubarial" salivary glands, were found in nasopharynx prostate-specific membrane antigen (PSMA)...
Purpose: A system has been developed which recognizes and classifies Digital Imaging Communication in Medicine contour data with minimal human intervention. It allows researchers to overcome obstacles tax analysis mining systems, including inconsistent naming conventions differences age or resolution.
Abstract Despite a great improvement in target volume dose conformality made possible recent years by modulated therapies, xerostomia remains common and severe side effect for head‐and‐neck radiotherapy patients. It is known that parotid glands exhibit spatially varying response; however, the relative importance of subregions throughout entire gland has yet to be incorporated into treatment plan optimization, with current standard being minimize mean whole glands. The regions within...