A5101441292- Bone Metabolism and Diseases
- Bone health and treatments
- NF-κB Signaling Pathways
- Biomarkers in Disease Mechanisms
- Inflammatory mediators and NSAID effects
- Bone health and osteoporosis research
- Orthopaedic implants and arthroplasty
- Cytokine Signaling Pathways and Interactions
- TGF-β signaling in diseases
- Natural product bioactivities and synthesis
- Immune Response and Inflammation
- Cell death mechanisms and regulation
- Adipose Tissue and Metabolism
- MicroRNA in disease regulation
- Advanced X-ray and CT Imaging
- Selenium in Biological Systems
- Radiation Dose and Imaging
- Exercise and Physiological Responses
- Circular RNAs in diseases
- Osteoarthritis Treatment and Mechanisms
- Bacillus and Francisella bacterial research
- Parasites and Host Interactions
- Radiopharmaceutical Chemistry and Applications
- Bone and Joint Diseases
- Dental Radiography and Imaging
Wonkwang University
2012-2025
Center for Rheumatology
2009
Abstract Osteoclasts are multinucleated cells that formed by the fusion of mononuclear osteoclasts, which is an essential process in bone resorption leading to remodeling. Herein we show GM-CSF promoted prefusion osteoclasts (pOCs). The expression receptor-α was significantly up-regulated at stage pOCs induced RANKL. dendritic cell-specific transmembrane protein (DC-STAMP), mediated inducing NFATc1 via induction c-Fos. c-Fos and regulated ERK signaling pathway. Inhibition suppressed DC-STAMP...
Abstract Background Even though osteoarthritis (OA) is the most common musculoskeletal dysfunction, there are no effective pharmacological treatments to treat OA due lack of understanding in pathology. To better understand mechanism pathogenesis and investigate its target, we analyzed miRNA profiles during verify role functional targets miR-488. Results Human articular chondrocytes were obtained from cartilage patients undergoing knee replacement surgery biopsy samples normal expression...
Excessive osteoclastic bone resorption plays a critical role in inflammation-induced loss such as rheumatoid arthritis and periodontal erosion. Therefore, identification of osteoclast targeted-agents may be therapeutic approach to the treatment pathological loss. In this study, we isolated chlorogenic acid (CGA) from fructus Gardenia jasminoides discover anti-bone resorptive agents. CGA is polyphenol with anti-inflammatory anti-oxidant activities, however, its effects on differentiation...
Protocatechuic acid (PCA) plays a critical role in nutritional metabolism; it is major metabolite of anthocyanins, which are flavonoids with range health benefits. PCA has variety biological activities including anti‐oxidant, antiinflammatory, anti‐apoptosis, and anti‐microbial activities. However, the pharmacological effect PCA, especially on osteoclastogenesis, remains unknown. We examined receptor activator NF‐κB ligand (RANKL)‐induced osteoclast differentiation bone resorption....
Ebselen is a non-toxic seleno-organic drug with anti-inflammatory and antioxidant properties that currently being examined in clinical trials to prevent treat various diseases, including atherosclerosis, stroke, cancer.However, no reports are available for verifying the pharmacological effects of ebselen on major metabolic bone diseases such as osteoporosis.In this study, we observed suppressed formation tartrate-resistant acid phosphatase (TRAP)-positive multinucleated cells an...
Purslane (Portulaca oleracea L.) is popular as a potherb in many areas of Europe, Asia, and the Mediterranean region widely distributed around globe. It has wide range pharmacological effects, such antibacterial, anti-aging, anti-inflammatory, anti-oxidative properties. Although extract purslane numerous beneficial its effect on osteoclasts remains unknown. We aimed to investigate anti-osteoclastogenic activity vitro vivo elucidate underlying mechanism. The differentiation function bone...
Excessive bone resorption plays a central role in the development of inflammatory diseases, including osteoporosis and rheumatoid arthritis.Thus, identification agents that can effectively suppress excessive osteoclast formation function is crucial for prevention treatment loss.Umbelliferone (Umb), derivative coumarin, natural bioactive compound with anti-inflammatory antioxidant properties.However, effect Umb on metabolic diseases unknown.In this study, we found exhibited strong inhibitory...
Background/Objectives: Muscle atrophy, defined by diminished muscle mass and function, is a notable concern associated with aging, disease, glucocorticoid treatment. Pueraria montana var. lobata extract (PMLE) demonstrates multiple bioactive properties, such as antioxidant, anti-inflammatory, metabolic regulatory activities; however, its role in atrophy has not been extensively investigated to date. This study examined how PMLE influences both cell differentiation dexamethasone (DEX)-induced...
Parthenolide, a natural product derived from Feverfew, prevents septic shock and inflammation. We aimed to identify the effects of parthenolide on RANKL (receptor activator <TEX>$NF-{\kappa}B$</TEX> ligand)-induced differentiation bone resorbing activity osteoclasts. In this study, dose-dependently inhibited RANKL-mediated osteoclast in BMMs, without any evidence cytotoxicity phosphorylation p38, ERK, <TEX>$I{\kappa}B$</TEX>, as well <TEX>$I{\kappa}B$</TEX> degradation by treatment....
The increase of bone-resorbing osteoclast activity in bone remodeling is the major characteristic various diseases. Thus, inhibiting osteoclastogenesis and function may be an effective therapeutic target for Betulinic acid (BA), a natural plant-derived pentacyclic triterpenoid compound, known to possess numerous pharmacological biochemical properties including anti-inflammatory, anticancer, antiadipogenic activity. However, effect BA on differentiation metabolism has not been demonstrated so...
Abstract Excessive bone‐resorbing osteoclast activity during bone remodeling is a major feature of diseases, such as osteoporosis. Therefore, the inhibition formation and resorption can be an effective therapeutic target for various diseases. Gryllus biomaculatus (GB) has recently been approved alternative food source because its high nutritional value environmental sustainability. Traditionally, GB known to have pharmacological properties, including antipyretic blood pressure‐lowering...
Abstract Interleukin‐3 (IL‐3) is produced under various pathological conditions and thought to be involved in the pathogenesis of inflammatory diseases; however, its function bone homeostasis normal or nature downstream molecular targets remains unknown. Here we examined effect IL‐3 on osteoclast differentiation from mouse human marrow‐derived macrophages (BMMs). Although can induce multiple myeloma marrow cells, greatly inhibited BMMs isolated healthy donors. These inhibitory effects were...
Costunolide, a sesquiterpene lactone, exhibits anti‐inflammatory and anti‐oxidant properties mediates apoptosis. However, its effects mechanism of action in osteoclasts remain unknown. Herein, we found that costunolide significantly inhibited RANKL‐induced BMM differentiation into dose‐dependent manner without affecting cytotoxicity. Costunolide did not regulate the early signaling pathways RANKL, including mitogen‐activated protein kinase NF‐κB pathways. suppressed nuclear factor activated...
It has been reported that Janus tyrosine kinase (JAK)-dependent signaling pathways play a critical role in the pathogenesis of numerous malignancies and immune reactions, inhibition JAK implicated cell growth inhibition. The which on osteoclast differentiation anti-bone resorptive activity is not well understood. In this study, we investigated effects pan-JAK inhibitor, pyridone 6, bone-resorption vitro ex vivo. Pyridone 6 inhibited mouse bone marrow macrophage (BMM) cultures stimulated by...
VapB has been shown to regulate calcium homeostasis in amyotrophic lateral sclerosis. Calcium signaling is also important metabolic bone diseases, but the role of generation osteoclasts for resorption during osteoclastogenesis not known. Therefore, we investigated RANKL-induced osteoclast differentiation. Interestingly, induced osteoclastogenesis, and regulates differentiation by modulating NFATc1. The results suggest that via PLCγ2-Ca(2+)-NFAT signaling. involvement VapB-regulated was...
Vigeo is a mixture of fermented extracts Eleutherococcus senticosus Maxim (ESM), Achyranthes japonica (Miq.) Nakai (AJN), and Atractylodes Koidzumi (AJK) manufactured using the traditional Korean nuruk fermentation method. Although bioactive effects ESM, AJN, AJK have already been reported, pharmacological not proven. Therefore, in this study, we investigated whether had inhivitory on lipopolysaccharide (LPS)-induced inflammatory bone loss vivo receptor activator nuclear factor-B ligand...
Receptor activator of NF-<TEX>${\kappa}B$</TEX> ligand (RANKL) triggers the differentiation bone marrow-derived monocyte/macrophage precursor cells (BMMs) hematopoietic origin into osteoclasts through activation mitogen-activated protein (MAP) kinases and transcription factors. Recently, reactive oxygen species (ROS) antioxidant enzymes were shown to be closely associated with RANKL-mediated osteoclast differentiation. Although glutaredoxin2 (Glrx2) plays a role in cellular redox...