A5007069616- Pregnancy and preeclampsia studies
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Screening and Diagnostics
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Neonatal and fetal brain pathology
- Maternal and fetal healthcare
- Ectopic Pregnancy Diagnosis and Management
- Ultrasound and Hyperthermia Applications
- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Parasites and Host Interactions
- Ultrasound in Clinical Applications
- Neuroscience of respiration and sleep
- Ultrasound and Cavitation Phenomena
- Ultrasound Imaging and Elastography
- Radiology practices and education
- Mitochondrial Function and Pathology
- Pulmonary Hypertension Research and Treatments
- Pregnancy and Medication Impact
- Advancements in Solid Oxide Fuel Cells
- COVID-19 Impact on Reproduction
- Effects of Environmental Stressors on Livestock
- RNA regulation and disease
Imperial College London
2014-2023
University of Amsterdam
2022
National Health Service
2022
Queen Charlotte's and Chelsea Hospital
2014-2022
American Journal Experts (United States)
2022
University College London
2022
Imperial College Healthcare NHS Trust
2019-2021
University of Cambridge
1996-2020
Hammersmith Hospital
2014
Peterborough and Stamford Hospitals NHS Foundation Trust
2011
Preeclampsia continues to be a prevalent pregnancy complication and underlying mechanisms remain controversial. A common feature of preeclampsia is utero-placenta hypoxia. In contrast the impact hypoxia on placenta fetus, comparatively little known about maternal physiology.We adopted an integrative approach investigate inter-relationship between chronic during with maternal, placental, fetal outcomes, in preeclampsia. We exploited novel technique using isobaric hypoxic chambers vivo...
Abstract Wolfram syndrome was originally described as a combination of familial juvenile‐onset diabetes mellitus and optic atrophy. Other neurological features subsequently emerged, “DIDMOAD” ( d iabetes i nsipidus, m ellitus, o ptic trophy, eafness) became commonly accepted acronym. Here, we describe 4 further cases from 2 families, in whom there occurred previously unrecognized features, central apnea neurogenic upper airway collapse, together precipitating primary respiratory failure...
Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, VL/HIV co-infected patients suffer from frequent VL relapse. Here, we follow cohorts of with or without Ethiopia. By the end study, 78.1% VL/HIV—but none patients—experience Despite defined cure, maintain higher parasite loads, lower BMI, hepatosplenomegaly, and pancytopenia. We identify three immunological markers associated relapse patients: (1) failure to restore antigen-specific...
Key points Fetal heart rate variability (FHRV) has long been recognised as a powerful predictor of fetal wellbeing, and decrease in FHRV is associated with compromise. However, the mechanisms by which reduced chronically hypoxic fetus have yet to be established. The sympathetic parasympathetic influences on mature at different rates throughout life, can assessed time domain power spectral analysis FHRV. In this study instrumented sheep late gestation, we analysed daily over 16 day period...
High-intensity focused ultrasound can ablate blood flow in the sheep placenta and may be translatable to human twin-twin transfusion syndrome.
Introduction Previous novel COVID-19 pandemics, SARS and middle east respiratory syndrome observed an association of infection in pregnancy with preterm delivery, stillbirth increased maternal mortality. COVID-19, caused by SARS-CoV-2 infection, is the largest pandemic living memory. Rapid accrual robust case data on women their babies affected suspected or confirmed will inform clinical management preventative strategies current future outbreaks. Methods analysis The neonatal outcomes...
Impetigo herpetiformis or gestational pustular psoriasis can account for 4.25% of all pregnancy dermatoses seen. Unlike other dermatoses, it be associated with constitutional symptoms including fever, rigors, arthralgia and complications secondary infection sepsis. There is an increased risk fetal anomalies stillbirths. A 25-year-old para 1 presented to primary care at 7 weeks gestation a peri-umbilical rash non-responsive topical steroids underwent hospital admission 31 fever widespread...
The hypoxic fetus is at greater risk of cardiovascular demise during a challenge, but the reasons behind this are unknown. Clinically, progress has been hampered by inability to study human non-invasively for long period gestation. Using experimental animals, there also an induce gestational hypoxia while recording fetal function as pregnancy occurring. We use novel technology in sheep that combines induction controlled chronic with simultaneous, wireless blood pressure and flow signals from...
In mammals, pregnancy complicated by chronic hypoxia can program hypertension in the adult offspring. However, mechanisms remain uncertain because partial contributions of challenge on placenta, mother, and fetus are difficult to disentangle. Here, we used chicken embryo—an established model system that permits isolation direct effects developmental cardiovascular offspring, independent additional mother or placenta. Fertilized eggs were exposed normoxia (N; 21% O 2 ) (H; 13.5%–14% from...
Abstract Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through uterus. However, further development of technique overcome technical challenges targeting occluding intact skin remains essential translation into human studies. So too does assessment fetal wellbeing following this procedure, demonstration persistence vascular occlusion. At 115 ± 10 d gestational age (term~147...
High-intensity focused ultrasound (HIFU) is a non-invasive method of selective placental vascular occlusion, providing potential therapy for conditions such as twin–twin transfusion syndrome. In order to translate this technique into human studies, evidence prolonged fetal recovery and maintenance healthy physiology following exposure HIFU essential. At 116 ± 2 days gestation, 12 pregnant ewes were assigned control ( n = 6) or occlusion groups anaesthetized. Placental blood vessels...
To investigate the effects of antenatal administration betamethasone on fetal Doppler and short term heart rate variation (CTG-STV) in early growth restricted (FGR) fetuses. Post hoc analysis data derived from TRUFFLE study, a prospective, multicenter, randomized management trial severe onset FGR. Repeat CTG-STV measurements between last recording within 48 hours before first dose (baseline value) for 10 days after were evaluated. Multilevel was performed to analyze longitudinal course...
ABSTRACT Visceral leishmaniasis (VL) has emerged as a clinically important opportunistic infection in HIV patients, VL/HIV co-infected patients suffer from frequent VL relapse. Here, we followed cohorts of with or without co-infections Ethiopia and collected detailed clinical immunological data during 12 months follow-up. By the end study 78.1% but none only had relapsed. Despite defined cure, maintained high parasite loads, low BMI, hepatosplenomegaly pancytopenia throughout During...
Abstract Introduction Data on the outcomes of early‐onset twin–twin transfusion syndrome (TTTS), diagnosed before 18 weeks gestational age (GA), are sparse. We aimed to review diagnosis, management and TTTS. Material methods Pregnancy records at a single referral unit 2010‐6 were reviewed. In TTTS cases, data for pregnancy characteristics, interventions collected. PubMed Scopus databases searched studies including pregnant women with The primary outcome measure was livebirths. Results Case...
HIFU is a non-invasive technique to ablate tissue or occlude vasculature which may have human placental and fetal applications. Our aim was assess short-term maternal responses ablation of vasculature. 15 pregnant sheep were instrumented with vascular catheters flow probes at 116 ± 1d gestational age (term 147d) exposed sham vasculature, targeted colour Doppler. A standard treatment protocol exposures (1.7 MHz, 1.2 mm focus, 5 s exposure, 2 spaced, intensity 5000 Wcm−2) applied through the...
Fetoscopic laser ablation of placental vasculature is a successful but invasive treatment Twin–twin transfusion syndrome. HIFU non-invasive used to ablate tissue and occlude vasculature, although not previously vasculature. Our aim was test in pregnant sheep model. Placental targeted for exposure with an integrated ultrasound colour Doppler transducer head. (1.7 MHz, 1.2 mm focus, 5 s exposure, 5–20 interval, 1–2 spaced, acoustic power 40–80 W, free-field spatial peak intensity 3000–6000...
To investigate and compare the effect of simulator training on quantitative scores for ultrasound-related skills trainees with novice level ultrasound experience expert operators.Three (comprising 11, 32, 23 participants) one (10 subgroups undertook an simulation session. Pre- post-training test were collected each subgroup. Outcome measures as follows: mean accuracy score obtaining correct anatomical plane, percentage correctly acquired target planes, number movements, time to achieve...