A5089000333- Hair Growth and Disorders
- Gut microbiota and health
- Historical Gender and Feminism Studies
- Diet and metabolism studies
- Skin and Cellular Biology Research
- Lipid metabolism and disorders
- Gestational Diabetes Research and Management
- Chromatography in Natural Products
- CRISPR and Genetic Engineering
- Medicinal Plant Pharmacodynamics Research
- Wheat and Barley Genetics and Pathology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Apelin-related biomedical research
- Wnt/β-catenin signaling in development and cancer
- Retinoids in leukemia and cellular processes
- Clostridium difficile and Clostridium perfringens research
- Genetic Mapping and Diversity in Plants and Animals
- Asthma and respiratory diseases
- Down syndrome and intellectual disability research
- Genetics and Plant Breeding
- Insect symbiosis and bacterial influences
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Signaling Pathways in Disease
- Chronic Disease Management Strategies
St. Jude Children's Research Hospital
2025
Dali University
2025
Inner Mongolia Agricultural University
2019-2024
Peking University
2017-2024
Peking University People's Hospital
2017-2024
Ministry of Agriculture and Rural Affairs
2024
Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences
2024
China Tobacco
2023-2024
Henan Provincial People's Hospital
2017-2023
Zhengzhou University
2017-2023
Introduction Down syndrome (DS), the presence of a supernumerary chromosome 21, is associated with cognitive dysfunction caused by early neurodegenerative processes. Alterations in gut microbiota were observed Chinese children DS, and genus Blautia was function these children. Therefore, it crucial to understand detailed composition this group at species level explore effect specific on function. Methods In study, -specific amplicon sequencing conducted identify 15 DS matched healthy Results...
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease characterized by the development of subpleural foci myofibroblasts that contribute to exuberant fibrosis. Recent studies revealed pleural mesothelial cells (PMCs) undergo epithelial–mesenchymal transition (EMT) and play pivotal role in IPF. In animal model, bleomycin induces exhibiting similar what seen human It not known yet whether EMT PMCs. present study, PMCs were cultured treated with bleomycin. The protein levels...
Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The link between microbiota diet management contributes to homeostasis in GDM. Therefore, it crucial understand the structure of gut GDM explore effect dietary on structure. In this study, we analyzed composition 27 30 healthy subjects at two time points using Illumina HiSeq 2500 platform. taxonomy analyses suggested overall...
Due to recent innovations in gene editing technology, great progress has been made livestock breeding, with researchers rearing gene-edited pigs, cattle, sheep, and other livestock. Gene-editing technology involves knocking in, out, deleting, inhibiting, activating, or replacing specific bases of DNA RNA sequences at the genome level for accurate modification, such processes can edit genes a fixed point without needing templates. In years, although clustered regularly interspaced short...
Compound Kushen injection (CKI) is the most widely used traditional Chinese medicine preparation for comprehensive treatment of colorectal cancer (CRC) in China, but its underlying molecular mechanisms action are still unclear. The present study employed a network pharmacology approach, which we constructed "bioactive compound-target-pathway" network. Experimental RNA sequencing (RNA-Seq) analysis was performed to identify key subsequent experimental validation. Cell cycle, proliferation,...
Potato virus Y (PVY) mainly infects Solanaceous crops, resulting in considerable losses the yield and quality. Iron (Fe) is involved various biological processes plants, but its roles resistance to PVY infection has not been reported. In this study, foliar application of Fe could effectively inhibit early PVY, a full-length transcriptome Illumina RNA sequencing was performed investigate modes action PVY-infected Nicotiana tabacum. The results showed that 18,074 alternative splicing variants,...
Background: Dysregulation and pyroptosis of T-helper (Th) cells inflammatory cytokines have been implicated in the pathogenesis chronic obstructive pulmonary disease (COPD). However, immune response mechanisms as a consequence tobacco smoke exposure are not fully understood. We hypothesized that cigarette smoke-induced inflammation could be modulated through cytokine milieu T-cell nicotinic acetylcholine receptors (nAChRs). Methods: The proportions peripheral blood Th1 Th2 from patients with...
Gestational diabetes mellitus (GDM) is a high-risk pregnancy complication that associated with metabolic disorder phenotypes, such as abnormal blood glucose and obesity. The active interface between gut microbiota diet contributes to homeostasis in GDM. However, the contributions of mycobiome have been neglected. Here, we profiled fungi GDM healthy subjects at two time points investigate whether variations correlate key features host metabolism management this observational study. We...
Abstract Background Cashmere goats make an outstanding contribution to the livestock textile industry and their cashmere is famous for its slenderness softness has been extensively studied. However, there are few reports on molecular regulatory mechanisms of secondary hair follicle growth cycle in goats. In order explore regular transition through role key genes this cycle, we used a transcriptome sequencing technique sequence skin Inner Mongolian during different months. We analyzed...
Down's syndrome (DS), a common chromosomal disease caused by chromosome 21 trisomy, is the main cause of cognitive impairment in children worldwide. Emerging evidence suggests that microbiota-gut-brain axis plays potential role impairment. However, data regarding gut microbiota alterations DS patients remain scarce, especially from with DS. This case-control study was conducted to explore composition Chinese children. Additionally, association between and function evaluated. Microbiota...
Cashmere is the fine bottom hair produced by secondary follicles of skin. This economically important. Previous studies our research group have shown that exogenous melatonin (MT) can regulate periodic growth follicles, induce development villi, and alter expression some genes related to follicle development. Few on regulation villus MT binding receptors been published. In this study, was implanted subcutaneously behind ear Inner Mongolia cashmere goats. RT-qPCR, in situ hybridization,...
Airway hyperresponsiveness (AHR) in asthma is predominantly caused by increased sensitivity of bronchial smooth muscle cells (BSMCs) to stimuli. The sarcoplasmic reticulum (SR)-Ca(2+) release channel, known as ryanodine receptor (RyR), mediates the contractive response BSMCs FK506-binding protein 12.6 kD (FKBP12.6) stabilizes RyR2 channel a closed state. However, interaction FKBP12.6 with AHR remains unknown. This study examined asthma. and expression was determined rat model treated...
Secondary hair follicle growth in cashmere goats has seasonal cycle changes, and melatonin (MT) a regulatory effect on the cycle. In this study, length of was measured by implanting MT live goats. The results indicated that continuous implantation promoted to enter anagen 2 months earlier induce secondary development. HE staining skin tissues showed number follicles MT-implanted significantly higher than control ( P < 0.05). Transcriptome sequencing tissue used identify differentially...
The growth of secondary hair follicles in cashmere goats follows a seasonal cycle. Melatonin can regulate the cycle growth. In this study, melatonin was implanted into live goats. After skin samples were collected, transcriptome sequencing and histological section observation performed, weighted gene co-expression network analysis (WGCNA) used to identify key genes establish an interaction network. A total 14 modules defined by WGCNA, combined with previous results, it found that blue module...
Abstract Background Although several clinical studies have analysed the relationship between levels of vascular endothelial growth factor (VEGF) and apelin-13 in venous blood retinopathy prematurity (ROP), no definitive conclusions been reached. This study aimed to investigate VEGF ROP. Methods Differences plasma were two groups infants born with birth weight < 1500 g gestational age 32 weeks at Peking University People’ s Hospital. One group comprised diagnosed ROP other was a control...
Vitamin A deficiency and mitochondrial dysfunction are both associated with neural differentiation-related disorders, such as Alzheimer's disease (AD) Down syndrome (DS). The mechanism of vitamin A-induced differentiation the notion that can regulate morphology function mitochondria in its induction through RIP140/PGC-1α axis unclear. aim this study was to investigate roles underlying mechanisms differentiation. Human neuroblastoma cells (SH-SY5Y) were used a model stem cells, which...
Histone acetylation and mitochondrial function contribute importantly to neural differentiation, which is critically associated with neurodevelopmental disorders such as Down Syndrome (DS). However, whether how histone regulates further affects differentiation has not been well described. In this study, when treated retinoid acid (RA), the human neuroblastoma SH-SY5Y cell line was used a model. We found that of H3, especially H3 lysine 14 (H3K14ac), function, including biogenesis electron...
With the continuous update of gene editing technology, great progress has been made in livestock breeding, researchers have produced edited pigs, cattle, sheep and other improved livestock. Gene technology is a genetic means to knock in, out, delete, inhibit, activate or replace specific bases DNA RNA sequences at genome level achieve accurate modification, can edit genes fixed point without need for templates. In recent years, although regular clusters interspaced short palindromic repeats...