A5081244871- Inflammatory Bowel Disease
- Gut microbiota and health
- Microscopic Colitis
- Pharmaceutical studies and practices
- Iron Metabolism and Disorders
- Adolescent and Pediatric Healthcare
- Diverticular Disease and Complications
- Hemoglobinopathies and Related Disorders
- Immunodeficiency and Autoimmune Disorders
- Microbial Metabolites in Food Biotechnology
- Clostridium difficile and Clostridium perfringens research
- Anorectal Disease Treatments and Outcomes
- Clinical Nutrition and Gastroenterology
- Prion Diseases and Protein Misfolding
- Nursing Education, Practice, and Leadership
- Healthcare Regulation
- Child Nutrition and Feeding Issues
- Enterobacteriaceae and Cronobacter Research
- Flame retardant materials and properties
- Cultural Competency in Health Care
- Ophthalmology and Eye Disorders
- High-Temperature Coating Behaviors
- Alcoholism and Thiamine Deficiency
- Pharmacological Effects of Natural Compounds
- Chronic Disease Management Strategies
Children's Hospital of Philadelphia
2018-2025
University of Pennsylvania
2019-2025
University of Alberta
2018
British Columbia Children's Hospital
2016
University of British Columbia
2016
Abstract Background and Aims Dysbiosis of the gut microbiota is a well-known correlate pathogenesis inflammatory bowel disease [IBD]. However, few studies have examined microbiome in very early-onset [VEO] IBD, which defined as onset IBD before 6 years age. Here we focus on viral portion microbiome—the virome—to assess possible associations with processes, reasoning that any viruses potentially associated might grow more robustly younger subjects, so be detectable. Methods Virus-like...
Abstract Background Recent studies have shown that oral combination antibiotics may improve disease course in refractory inflammatory bowel (IBD). Here, we describe the use of as salvage therapy ulcerative colitis (UC), Crohn’s colitis, and IBD-unclassified (IBD-U) at a large pediatric IBD center. Methods Clinical response, activity indices, adverse events, clinical outcomes were measured up to 1 year after antibiotic treatment this retrospective cohort study children with medically colitis....
Abstract Background & Aims Epidemiological studies have suggested an association between the inflammatory potential of dietary patterns and Crohn’s disease (CD). However, relationships these determinants with microbiome remain largely unknown. In this cross-sectional study, we evaluate habitual diet, as assessed by modified Children-Dietary Inflammatory Index (mC-DII), fecal metabolome children CD in comparison to healthy children. Methods A study including 51 6 18 years age 50 controls...
Perianal fistulising disease can affect up to 25% of patients with Crohn's [CD] and lead significant morbidity. Although the role gut microbiota in inflammatory bowel [IBD] has been increasingly recognised, its fistula development scarcely studied. Here, we aimed define microbial signature associated perianal CD children.A prospective observational study including children age 6-18 years a diagnosis was conducted. Stool samples rectal swabs were collected. from without healthy included as...
Abstract Background Iron deficiency (ID) and anemia are one of the most common extraintestinal manifestations inflammatory bowel disease (IBD), usually complicating course both in ulcerative colitis Crohn’s disease. Despite their high prevalence significant impact on patients, this particular aspect is still underestimated by clinicians. Although guidelines have been recently published to address problem, these recommendations do not pediatric specific concerns provide guidance as how...
Abstract OBJECTIVE The intestinal microbiota plays a pivotal role in the inflammation associated with inflammatory bowel disease (IBD) through their interaction mucosal immune system. Prebiotic interventions using inulin-type fructans increase faecal and bifidobacteria as well butyrate producing bacteria healthy volunteers. aim of this study was to assess effect two-month oligofructose-enriched inulin (OI) supplementation on microbiome composition, metabolome children IBD subclinical...
Neurological involvement in the inflammatory bowel disease (IBD) population is frequently underecognized spite of having significant morbidity. Its exact prevalence still unknown, varying between 0.2% and 47.5%, depending on definitions diagnostic methodology used (1). These complications may represent immune-mediated phenomenon directly attributable to IBD or associated with anti-tumor necrosis factor alpha (TNF-α), non-immune–mediated manifestations either secondary a micronutrient...
Background: Anemia is frequently observed in inflammatory bowel disease (IBD), with a higher prevalence children (16%–72%) compared to adults (4%–67%). Oral iron treatment associated poor tolerance leading low compliance and reduced effectiveness patients active due absorption, sequestration, greater gastrointestinal intolerance. As result, intravenous therapy typically preferred. Ferric carboxymaltose (FCM) an formulation that allows for larger doses be administered single session, reducing...
In March 2014, medical educators from Canada and Oman collaborated to shape the foundation of health advocacy training in Oman. Using existing research innovative tools, two workshops were developed, representing first formalised approach for trainees The development application highlighted many unique challenges opportunities training. This article summarises process developing implementing as well feedback participants short-term consequences. Furthermore, this seeks explore complexities...
Abstract Background Anemia is frequently encountered in inflammatory bowel disease (IBD) with studies reporting an even greater prevalence among children (16–72%) than adults (4–67%) at any given time during course. commonly a result of chronic iron deficiency (ID) and inflammation, the two conditions often overlapping. Many have shown that gastroenterologists underecognize undertreat these conditions. Moreover, there are currently no pediatric-specific guidelines. To align clinical practice...
The present study sought to determine the long-term growth consequences after a pulmonary exacerbation in children with cystic fibrosis (CF).Retrospective cohort of pediatric patients CF hospital admission for exacerbation. Logistic regression used risk factors failure recover baseline body mass index (BMI) percentile.Of 72 patients, 43% failed their BMI percentile 12 months discharge and these also had lower forced expiratory volume 1 second at follow-up. A greater decrease weight from was...
<title>Abstract</title> <bold>Background:</bold> Diet plays a critical role in development and progression of Crohn’s disease (CD). Dietary indices are important tools to evaluate diet quality dietary inflammatory potential, we investigated the associations it with pediatric CD. <bold>Method:</bold> A cross-sectional study including 144 children CD (122 clinically active 22 quiescent disease) 57 healthy controls 6-18 years age was conducted. intake estimated using three 24-h recalls....