A5046974813- Genetics, Aging, and Longevity in Model Organisms
- Muscle Physiology and Disorders
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Nuclear Structure and Function
- RNA Research and Splicing
- Circadian rhythm and melatonin
- Single-cell and spatial transcriptomics
- Spaceflight effects on biology
- Education and Learning Interventions
- Mesenchymal stem cell research
- Tryptophan and brain disorders
- Heat shock proteins research
- Alzheimer's disease research and treatments
- Pluripotent Stem Cells Research
- Autophagy in Disease and Therapy
- Muscle metabolism and nutrition
- Tissue Engineering and Regenerative Medicine
- Metabolism, Diabetes, and Cancer
- Innovation in Digital Healthcare Systems
- Birth, Development, and Health
- Pancreatic function and diabetes
- Technology and Data Analysis
Yonsei University
2023
Pohang University of Science and Technology
2010-2021
Broad Center
2017-2020
University of California, San Francisco
2017-2020
Life University
2011
Significance Reactive oxygen species (ROS) have long been thought to cause aging and considered be toxic byproducts generated during mitochondrial respiration. Surprisingly, recent studies show that modestly increased ROS levels lengthen lifespan, at least in the roundworm Caenorhabditis elegans . It was unclear how of potentially are regulated promote longevity. Here we demonstrate activate two proteins, AMP-activated kinase (AMPK) hypoxia-inducible factor 1 (HIF-1), longevity by increasing...
Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation that is required for regeneration, but it remains unknown if the trajectory and dynamics of change with age. Here, we use timelapse imaging single cell RNA-seq measure trajectories rates in young aged MuSCs. We find conserved cells, develop effective machine learning classifiers Using behavior analysis RNA velocity, kinetics are delayed MuSCs, suggesting changes may contribute impaired function...
Mitochondria are essential for various biological processes including cellular energy production. The oxidative stress theory of aging proposes that mitochondria play key roles in by generating reactive oxygen species (ROS), which indiscriminately damage macromolecules and lead to an age-dependent decline function. However, recent studies show increased levels ROS or inhibition mitochondrial function can actually delay increase lifespan. aim this review is summarize findings regarding the...
A conserved protein kinase VRK-1 increases life span by activating a key energy sensor AMPK in the roundworm C. elegans .
Abstract The nematode Caenorhabditis elegans is a widely used model for genetic dissection of animal behaviors. Despite extensive technical advances in imaging methods, it remains challenging to visualize and quantify C. behaviors three-dimensional (3-D) natural environments. Here we developed an innovative 3-D method that enables quantification behavior Furthermore, the first time, characterized 3-D-specific behavioral phenotypes mutant worms have defects head movement or mechanosensation....
MON-2, which mediates Golgi-endosome trafficking, mitochondrial inhibition–induced longevity by enhancing autophagy.
Abstract Murine muscle stem cells (MuSCs) experience a transition from quiescence to activation that is required for regeneration, but it remains unclear if the states and rates of are uniform across cells, or how features this process may change with age. Here, we use timelapse imaging single cell RNA-seq measure trajectories in young aged MuSCs. We find trajectory conserved develop effective machine learning classifiers Using behavior analysis RNA velocity, kinetics delayed MuSCs,...
The second International Symposium on the Genetics of Aging and Life History was held at campus Daegu Gyeongbuk Institute Science Technology (DGIST), Daegu, South Korea, from May 14 to 16, 2014. Many leading scientists in field aging research all over world contributed symposium by attending presenting their recent work thoughts. aim stimulate international collaborations interactions among who biology aging. In symposium, most exciting presented, covering a wide range topics, including...
The penetration rate of smartphones in Korea is over 95%.Mobile applications are now widely accessible; therefore, numerous products and services experiencing digitfal transformation.Notably, the music industry has changed terms consumption.with excellent accessibility, mobility, quality, streaming have gained popularity rapidly among younger generations.However, unfortunately, these practical rather difficult for seniors.As a consequence, seniors' application usage very low.Complex...
ABSTRACT Decline in the skeletal muscle stem cell (MuSC) function is a major contributor to age-associated impairments regeneration and function. The ability of MuSCs activate (i.e. exit quiescence, enter cycle, divide) following injury critical step that initiates regeneration. However, mechanisms regulate MuSC activation are poorly understood. Here, we show function, specifically speed by which cells progress through G0-G1, declines tremendously with age mouse MuSCs. Using number vivo...