A5000829453- Virus-based gene therapy research
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- SARS-CoV-2 and COVID-19 Research
- Herpesvirus Infections and Treatments
- Leptospirosis research and findings
- Parvovirus B19 Infection Studies
- Vector-borne infectious diseases
- Reproductive tract infections research
- Vector-Borne Animal Diseases
- Animal Disease Management and Epidemiology
- Viral Infections and Vectors
- Veterinary Oncology Research
- Cancer Research and Treatments
- Urinary Tract Infections Management
- Rabies epidemiology and control
- HIV Research and Treatment
- Poxvirus research and outbreaks
- Virology and Viral Diseases
- Bat Biology and Ecology Studies
- Gut microbiota and health
- Plant Virus Research Studies
- COVID-19 epidemiological studies
- Veterinary medicine and infectious diseases
- Immunotherapy and Immune Responses
University of Bologna
2016-2025
Azienda USL di Bologna
2024
Cardiff University
2018
A 29 nucleotide deletion in open reading frame 8 (ORF8) is the most obvious genetic change severe acute respiratory syndrome coronavirus (SARS-CoV) during its emergence humans. In spite of intense study, it remains unclear whether actually reflects adaptation to Here we engineered full, partially deleted (-29 nt), and fully ORF8 into a SARS-CoV infectious cDNA clone, strain Frankfurt-1. Replication resulting viruses was compared primate cell cultures as well Rhinolophus bat cells made...
Equine piroplasmosis is a tick-borne disease caused by Babesia and Theileria species. Despite its presence in Europe, no laboratory testing required for animal movement, even though some countries remain free of this disease. Differentiating between species genotypes crucial to determine the most effective treatment, as dosage, active compounds, duration vary. However, diagnosis often challenging due genetic variability limited sensitivity molecular methods. The aims study were compare...
OPINION article Front. Vet. Sci., 10 February 2021Sec. Veterinary Experimental and Diagnostic Pathology Volume 8 - 2021 | https://doi.org/10.3389/fvets.2021.619207
Parvoviruses of carnivores include three closely related autonomous parvoviruses: canine parvovirus (CPV), feline panleukopenia virus (FPV) and mink enteritis (MEV). These viruses cause a variety serious diseases, especially in young patients, since they have remarkable predilection for replication rapidly dividing cells. FPV is not the only species which infects cats; addition to MEV, new variants parvovirus, CPV-2a, 2b 2c also penetrated host-range, are able infect replicate cats, causing...
Toxoplasmosis occurs worldwide and is considered one of the most important food-borne parasitic zoonoses. The consumption undercooked meat containing viable tissue cysts ingestion environmental oocyst are sources infection. aim this retrospective study was to evaluate spread Toxoplasma gondii in province Bologna (Emilia-Romagna region) northern Italy, with a One Health approach, comparing seropositivity rates different animal species humans over last 19 4 years respectively. Analyses were...
Bats are source of coronaviruses closely related to the severe acute respiratory syndrome (SARS) virus. Numerous studies have been carried out identify new bat viruses SARS-coronavirus (bat-SARS-like CoVs) using a reverse-transcribed-polymerase chain reaction assay. However, qualitative PCR could underestimate prevalence infection, affecting epidemiological evaluation bats in viral ecology. In this work an SYBR Green-real time assay was developed for diagnosing infection with SARS-related...
Canine parvovirus type 2 (CPV-2) is the most important enteric virus infecting canids. It a rapidly evolving virus; after its emergence in 1970s, new antigenic variants (called CPV-2a, 2b and 2c) emerged replaced original type. The three are globally distributed with different frequencies levels of genetic variability. This study focused on VP2 gene sequence analysis phylodynamics CPV-2 which were detected 123 dogs showing clinical signs gastroenteritis collected Italy from 1994 to 2017.For...
Abstract Background Urine neutrophil gelatinase‐associated lipocalin (NGAL) is a promising biomarker of acute kidney injury (AKI) in dogs. Objectives To evaluate the utility urinary NGAL for characterizing AKI according to volume responsiveness, presence inflammation and sepsis, prognosis. Animals Dogs with (n = 76) healthy controls 10). Methods Prospective study. Clinical clinicopathologic data including absolute urine concentration (uNGAL) normalized creatinine (uNGALC) were measured upon...
The association between coronaviruses and bats is a worldwide phenomenon belonging to genus Rhinolophus are the reservoir host for several coronaviruses, including large number of viruses closely related genetically severe acute respiratory syndrome-coronavirus (SARS-CoV). We carried out survey in colonies Italian (Rhinolophus ferrumequinum) presence coronaviruses. Two 52 R. ferrumequinum captured from different areas tested positive by reverse transcription-PCR fragment RNA-dependent RNA...
Abstract Background Canine parvovirus (CPV) is one of the most important pathogens dogs. Despite vaccination, CPV infections are still ubiquitous in dogs, and three antigenic variants 2a, 2b 2c variously distributed canine population worldwide. To date, no information available on circulating some European countries. The aim this study was to genetically characterise detected ten dogs with clinical signs acute gastroenteritis Romania. presence Carnivore protoparvovirus 1 DNA investigated...
Cats are susceptible to feline panleukopenia virus (FPV) and canine parvovirus (CPV) variants 2a, 2b 2c. Detection of FPV CPV in apparently healthy cats their persistence white blood cells (WBC) other tissues when neutralising antibodies simultaneously present, suggest that may persist long-term the post-infection without causing clinical signs. The aim this study was screen a population 54 from Sardinia (Italy) for presence both DNA within buffy coat samples using polymerase chain reaction...
Canine distemper virus (CDV), canine adenovirus (CAdV) and parvovirus type 2 (CPV-2) cause disease in dogs ( Canis familiaris ). These, or closely related viruses, may also infect wild carnivores. The aim of this study was to investigate exposure CDV, CAdV CPV-2 among fox populations Norway. Arctic foxes n = 178) from High-Arctic Svalbard were investigated for antibodies against CDV. (n 301) red Low-Arctic 326) sub-Arctic 74) regions Finnmark County, Norway, the presence carnivore...
Canine circovirus (CanineCV) is a relatively new viral species, belonging to the family Circoviridae, whose pathogenic role still uncertain. Since its first description in one domestic dog 2011 from USA, several reports have been documenting distribution worldwide. Recently, CanineCV was also detected wild animals such as wolves, foxes and badgers. In order investigate presence genetic characteristics of Arctic Sub-Arctic regions, DNA internal organs (liver spleen) 51 arctic (Vulpes lagopus)...
Kennels may represent high-risk environments for the diffusion of Leptospira infection in dogs and consequently a threat to public health. This study describes an outbreak kennel Italy 2020, both with clinically ill asymptomatic dogs. Fifty-nine dogs, including three were tested spp. by microscopic agglutination test (MAT) real-time qPCR. Multi-locus sequence typing (MLST) analysis was used genotype identified leptospires. Thirty fifty-nine (50.9%) had MAT titer and/or molecular positivity...
Abstract Anaplasma phagocytophilum , platys and Ehrlichia canis responsible of diseases in dogs, are tick-borne pathogens with a proven or potential zoonotic role that have shown increasing prevalence worldwide. The aims this retrospective study were to assess the frequency spp. exposure dogs tested veterinary teaching hospital Italy over 9-year period, compare performance diagnostic tests used, evaluate correlations clinical data, genetically analyse identified bacteria. During 1322 by at...
Animals, including wildlife, are part of One-Health concept since many infectious diseases can affect both humans and animals. In this study, 126 red foxes (Vulpes vulpes) from Northern Italy in 2022–2023 were tested by molecular assays for Protoparvovirus carnivoran 1 (PPVC-1), Canine adenovirus type 2 (CAdV-1 CAdV-2), Circovirus canine (CanineCV), distemper virus (CDV), Leptospira spp. A total 39 (30.9%) infected with at least one pathogen five these coinfected: 20/126 (15.9%) positive...
Data on canine circovirus circulation among red foxes (Vulpes vulpes) are limited. We report the detection of in a fox from Italy. The virus was closely related to strains dogs (Canis lupus familiaris) rather than those foxes, suggesting possible transmission between two species.