Abstract Background Urine neutrophil gelatinase‐associated lipocalin (NGAL) is a promising biomarker of acute kidney injury (AKI) in dogs. Objectives To evaluate the utility urinary NGAL for characterizing AKI according to volume responsiveness, presence inflammation and sepsis, prognosis. Animals Dogs with (n = 76) healthy controls 10). Methods Prospective study. Clinical clinicopathologic data including absolute urine concentration (uNGAL) normalized creatinine (uNGALC) were measured upon...

Procalcitonin (PCT) is a valuable prognostic biomarker in human sepsis that predictive of organ dysfunction, septic shock and mortality. Data on PCT dogs limited. This study aimed to investigate the value baseline serial measurements with determine association between severity presence dysfunction. concentrations were measured citrated plasma samples collected from 53 at time admission (T0, n = 53) 24 h (T1, 35) 48 (T2, 30) post-admission using commercial ELISA. Dogs classified by (sepsis...

Sepsis, the life‐threatening organ dysfunction caused by a dysregulated host response to infection, is difficult identify and prognosticate for. In people with sepsis, procalcitonin (PCT) measurement aids diagnosis, enables therapeutic monitoring improves prognostic accuracy. This study used commercial canine PCT assay measure plasma concentrations in dogs gastric dilatation volvulus (GDV) syndrome sepsis. It was hypothesised that GDV sepsis have greater than healthy syndrome. Before...

Systemic inflammatory response syndrome (SIRS) and sepsis can be challenging to diagnose in cats. Retrospectively, we investigated the diagnostic prognostic potential of serum amyloid A (SAA), a major feline acute-phase protein (APP), population critically ill cats with SIRS related trauma or sepsis. total 56 (trauma n = 27; 29) were included compared healthy controls ( 18). SAA concentration was significantly increased controls, confirming its for detection systemic inflammation this...

Objectives The aim of the study was to evaluate association between triage body temperature (BT) and outcome in cats presenting emergency department (ED). Methods A retrospective observational conducted on presented ED. BT, clinical diagnosis were recorded. BT categorised as follows: normothermia (37.8–39.7°C); hyperthermia (⩾39.8°C); mild hypothermia (36.8–37.7°C); moderate (35.6–36.7°C); severe (33.1–35.5°C); critical (⩽33°C). Outcome ED death, euthanasia, hospital admission discharge. at...

The objective of the present study was to report outcome a novel technique urethral intra-abdominal anastomosis after transabdominal wall passage penis in dog with stent-related obstruction. Case report. A seven-year-old neutered male Cocker Spaniel. evaluated for urinary retention and overflow incontinence approximately 1-year duration. had self-expanding metallic stent placed 6 years prior as treatment pelvic stricture, secondary severe trauma. Stent fracture tissue hyperplasia were...

Double filtration plasmapheresis (DFPP) is a plasma exchange modality that allows selective clearance of high molecular weight proteins, potentially minimizing albumin loss and the need for volume replacement. Reports concerning DFPP use in dogs are scarce. This study evaluates quantitative net different proteins fractions an ex-vivo model using canine blood processed via DFPP. treatment with INUSpheresis processing 1.5, 2 3 volumes (PV) was performed. Plasma were measured reservoir bag at...

Abstract Objective To investigate the prognostic value of acute patient physiologic and laborartory evaluation (APPLE) score relevant clinicopathological markers in dogs with systemic inflammatory response syndrome (SIRS). Design Prospective observational cohort study. Setting Veterinary teaching hospital. Animals Thirty‐three SIRS admitted to intensive care unit (ICU) were compared 35 healthy control dogs. Dogs divided into septic ( n = 20) nonseptic 13) etiologies as survivors (alive...

The value of fractional excretion (FE) electrolytes to characterize and prognosticate acute kidney injury (AKI) is poorly documented in dogs.To evaluate the diagnostic prognostic roles FE dogs with AKI.Dogs (n = 135) AKI treated standard care (February 2014-December 2016).Prospective study. Clinical laboratory variables including electrolytes, were measured upon admission. Dogs graded according AKI-IRIS guidelines grouped features (volume-responsive, VR-AKI; intrinsic, I-AKI) outcome...

The current study was designed to evaluate the prevalence and prognostic significance of multiorgan dysfunction syndrome (MODS) in cats with sepsis.

Leptospirosis is an infectious disease that causes serious illness in dogs. For this reason, epidemiological and clinical studies focusing on characterization are widely advocated. The aim of study was to characterize the leptospires identified dogs with confirmed symptomatic acute leptospirosis. Leptospira spp. DNA detected urine, blood, or both samples from nine infected analyzed using multi-locus sequence typing (MLST) technique. Leptospires two were successfully typed: one as belonging...

Canine gastric dilatation-volvulus (GDV) is a life-threatening disease characterized by extensive tissue ischemia, hypoperfusion and systemic inflammation. Biomarkers that better reflect the severity of necrosis inflammation would aid clinicians in management these patients. This study aimed to investigate prognostic significance cell-free DNA (cfDNA), high-mobility group box-1 (HMGB1) procalcitonin (PCT) dogs with GDV. Concentrations cfDNA, HMGB1 PCT were measured citrated plasma samples...

Dogs with myxomatous mitral valve disease (MMVD) can experience progressive renal tubular damage and dysfunction. The prevalence of is not known in dogs stable MMVD.To evaluate MMVD by evaluation urinary neutrophil gelatinase-associated lipocalin (NGAL).Ninety-eight grouped according to the American College Veterinary Internal Medicine (ACVIM) staging (group B1, n = 23; group B2, 27; C + D, 48) 46 healthy dogs.Multicenter prospective observational study. Serum urine chemistry including NGAL...

Background: Sepsis is a life-threatening condition associated with an exacerbated production of both pro- and anti-inflammatory cytokines that can promote hyperactive response to infection or induce immunoparalysis. Data regarding the immune sepsis in cats are scarce. Establishing profiles chemokines feline characterize nature responses might enable individualized treatments be developed targeted. Objective: To evaluate cytokine chemokine network septic shock, investigate associations these...

Critical illness can be associated with transient alterations in circulating thyroid hormone concentrations, indicating the presence of non-thyroidal (NTI).NTI is well described humans, but there are few reports on its occurrence and prognostic significance dogs.This retrospective study assessed NTI a population dogs systemic inflammatory response syndrome (SIRS) investigated association disease severity (APPLEfast scores).A total 41 SIRS were included divided by origin (non-septic SIRS, n =...

Apolipoprotein-A1 (Apo-A1) acts as a negative acute phase protein (APP) during inflammatory states, and has potential prognostic value in people dogs with sepsis. The aim of this retrospective study was to investigate the association serum Apo-A1 concentration disease severity, multiorgan dysfunction syndrome (MODS) outcome population sepsis, assess its correlation major canine APPs.Ninety-nine uncomplicated sepsis (n = 78) or septic shock 21) were included. Apo-A1, C-reactive (CRP) amyloid...

Polytrauma is a common emergency condition in small animals and frequently associated with higher morbidity mortality rates compared to minor trauma. Multiple Organ Dysfunction Syndrome (MODS) major complication of extensive traumatic injury, carrying high risk death despite intensive care treatment. Little known about the prevalence prognostic impact MODS feline polytrauma. The current study aimed prospectively evaluate occurrence significance organ dysfunction at admission population...

Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker of tubular damage, and its elevation has been described in human canine cardiorenal syndrome. The aim was to evaluate the association between echocardiographic indexes urine NGAL (uNGAL) uNGAL normalized creatinine (uNGALC) dogs with MMVD. This multicentric prospective cross-sectional study. A total 77 MMVD at different ACVIM stages were included. All underwent echocardiography, serum chemistry, urinalysis. Echocardiographic...

Abstract Background Benefit of adding a second‐line immunosuppressive drug to glucocorticoids for the treatment non‐associative immune‐mediated hemolytic anemia (naIMHA) in dogs has not been defined prospectively. Hypothesis/Objectives Evaluate effectiveness different protocols naIMHA dogs. Animals Forty‐three client‐owned Methods Open label, randomized, clinical trial. Dogs were treated with methylprednisolone (M‐group), plus cyclosporine (MC‐group) or mycophenolate mofetil (MM‐group). as...

Heinz bodies (HBs) are known to interfere with automated hematology in cats, particularly the white blood cell (WBC) count. We evaluated influence of feline HBs on complete count (CBC) results obtained using a flow cytometry–based analyzer. retrospectively selected cats circulating and reviewed their CBCs, including red (RBC) indices, basophil/lobularity (Baso) WBC (WBCB), peroxidase (Perox) (WBCP), cytograms. Based presence or absence HB-related artifacts Baso cytogram, were grouped into...

Background: Three different phenotypes of septic shock based on changes in blood pressure and lactate are recognized people. Dysoxic shock, representing the combination fluid-refractory hypotension hyperlactatemia, is characterized by greater disease severity mortality compared to cryptic (hyperlactatemia alone) vasoplegic (hypotension with normal lactate). Little known about specifically its cats. Objective: To analyze characteristics prognostic implications three cats sepsis. Methods: Cats...