A5012120553- Ocular Oncology and Treatments
- Retinopathy of Prematurity Studies
- Intraocular Surgery and Lenses
- Retinal Development and Disorders
- Ophthalmology and Visual Impairment Studies
- Nonmelanoma Skin Cancer Studies
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Neurological Disorders and Treatments
- Connexins and lens biology
- Glioma Diagnosis and Treatment
- Retinal Diseases and Treatments
- Ophthalmology and Eye Disorders
- Pharmacology and Obesity Treatment
- Neonatal and fetal brain pathology
- Brain Metastases and Treatment
- Retinal and Macular Surgery
- Healthcare Systems and Public Health
- Neonatal Respiratory Health Research
- Multiple Sclerosis Research Studies
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Diet and metabolism studies
- Ophthalmology and Visual Health Research
- Peripheral Neuropathies and Disorders
Medical University of Sofia
2019-2024
Alexandrovska Hospital
2017-2022
To determine the prevalence of amblyopia and average age at first ophthalmological examination school-aged children from northwestern Bulgaria.Visual acuity testing, stereopsis, orthoptics, ocular motility, non-cycloplegic refraction, direct ophthalmoscopy, external inspection were performed. Cycloplegic refraction indirect ophthalmoscopy done as necessary. A total 2,054 (1,020 girls 1,034 boys) divided into three groups: 6 to 8 years (803 children), 10 (719 12 (530 children).A 1,861 (90.6%)...
Abstract Background Next‐generation sequencing (NGS)‐based method is being used broadly for genetic testing especially clinically and genetically heterogeneous disorders, such as inherited retinal degenerations (IRDs) but still not routinely molecular diagnostics in Bulgaria. Consequently, the purpose of this study was to evaluate effectiveness a diagnostic approach, based on targeted NGS identification disease‐causing mutations 16 Bulgarian patients with different IRDs. Methods We applied...
Cataract is a multifactorial disease with increasing prevalence age. Adult diabetics develop cataract earlier. Lens epithelial cells (LECs) exposed to oxidative stress (ROS), increased calcium deposit and membrane damage, undergo apoptosis, which results in lens opacification. Remaining LECs post-surgery leads posterior capsular opacification (PCO). This study’s aim was investigate the physiological characteristics of from cataractous diabetic non-diabetic lenses. Leader migration...
Aims/Purpose: Fundus flavimaculatus and Stargardt's disease are monogenic but heterogeneous entities leading to loss of central vision in adolescence, caused by more than 490 mutations the ABCA4 gene. We herein report clinical, phenotypic genetic characteristics adult onset fovea sparing disease. Methods: Two Caucasian males their 40s presenting with complaints paracentral scotomata underwent complete ophthalmic exam, visual field testing, optical coherence tomography (OCT), fundus...
Introduction: Sorsby fundus dystrophy is a rare autosomal dominant inherited retinal disease. The purpose of this case report providing evidence to link the novel variant TIMP3 c.319C>T, p.(Arg107Cys), classified as uncertain significance, clinical phenotype and consider assignment pathogenicity. Case: Thorough history comprehensive ophthalmological exam 51-year old female with presenile cataract difficulty in night vision were conducted. Visual acuity was 0.15 logMAR 0.05 right left eye,...
BACKGROUND: With the establishment of laser photocoagulation as a standard treatment modality for prethreshold retinopathy prematurity (ROP), dramatic reduction cases with ROP blindness and severe visual impairment have been reported. In same time, high refractive errors, common complication in especially treated infants, become main cause often impairment.
 AIM: The purpose our study was to analyse long-term status children at 3.5 years after laser-treatment type 1 ROP.
 PATIENTS...
Introduction. A dramatic increase of myopia worldwide has been observed in recent years. New risk factors for the development have target numerous investigations. The basis our research is correlation between serum levels vitamin D [25(OH)D] and itself. Purpose: To find out relationship 25(OH) myopia. Patients methods: study included 222 children with different refraction status. Full ophthalmologic examination, cycloplegic refraction, echobiometry were performed. 25(OH)D measured by liquid...
Синдромът на Marcus Gunn е рядко конгенитално заболяване, описано за първи път през 1883 г. от Robert Gunn. При класическата форма феномена се наблюдава повдигане или ретракция птозиралия горен клепач при движение долната челюст. В литературата са описват и редки форми синдрома, които не птоза. Представен рядък клиничен случай 8-месечно бебе, което диагностициран феноменът липсата конгенитална
Миелинизираните ретинални нервни влакна (МРНВ) или т.нар. fibrae medullaris retinae са рядка конгенитална аномалия. Най-често се наблюдават като изолирана очна находка, обикновено протичаща асимптомно, диагностицираща случайно при преглед по друг повод. Могат да и част от рядък синдром, характеризиращ с наличието на ипсилатерална МРНВ, аксиална миопия амблиопия - триадата Straatsma. Представяме три клинични случая този конгенитален синдром.
Фамилната ексудативна витреоретинопатия (ФЕВР) е рядко генетично и клинично хетерогенно заболяване, дължащо се на нарушен процес съдова диференциация, водещо до непълна васкуларизация ретината. ФЕВР определя като състояние, наподобяващо ретинопатия недоносеното, но с изразена фамилна предиспозиция при липсата анамнеза за преждевременно раждане и/или кислородотерапия. Характерна е, както асиметрията патологичния в двете очи един същи пациент, така голямата вариабилност симптомите членовете...
Introduction. Visual impairment and blindness are very common in children with developmental delay, seriously harming their intellectual, social, learning even physical development. Most reasons for mild visual refractive errors amblyopia, while optic nerve atrophy, retinal diseases central cortical the leading causes low vision (moderate severe impairment) blindness. ocular problems intellectually disabled often neglected treatable ignored. Purpose. The aim of our study was to determine...
Introduction: Determination of the scope surgical interventions, either retropositioning or myectomies horizontal rectus extraocular muscles is based on calculations that do not take into account distance insertion respective muscle. Aim : The aim this article to assess variations muscles. Materials and M ethods: research includes 63 children (126 eyes) with an average age 4 years months (the youngest 1y 2m old; oldest 16y old) comitant strabismus, all whom underwent surgery for a period 2...
Congenital optic disc anomalies are a group of structural malformations the and peripapillary zone, which often cause congenital severe visual impairment or blindness. They colobomas, Morning glory syndrome, aplasia hypoplasy nerve, staphylomas, megalopapilla, nerve pits, myelinated retinal fibres. We present а case report 3-year-old boy with two different – fibres disc.
Coats disease is a rare, in about 90% of cases unilateral idiopathic eye pathology. It characterized by telangiectatic and aneurysmally altered retinal blood vessels progressive intra- subretinal exudation, which can lead to exudative detachment. Most often the symptoms manifest advanced stages. Purpose: To report case with disease. 10 year old boy, admitted Eye Clinic University Alexandrovska Hospital – Sofia, leucocoria strabismus right eye. Method: Full ophthalmic orthoptic examination,...
Cataract is a leading cause of reversible blindness. Secondary cataract the result migration, proliferation, and epithelial-mesenchymal transformation (EMT) lens epithelial cells (LECs), induced by transforming growth factor β (TGFβ). The extracellular signal-regulated kinases 1 2 (ERK 1/2) casein kinase (CK2) are important for fundamental cellular processes. This study aimed to evaluate role CK2 in EMT LECs. Primary LECs cultures were obtained from age-related type diabetes-induced...