A5007260040- Cell Adhesion Molecules Research
- Blood Coagulation and Thrombosis Mechanisms
- Protease and Inhibitor Mechanisms
- Osteoarthritis Treatment and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Veterinary Equine Medical Research
- Bone Metabolism and Diseases
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Bone and Dental Protein Studies
- Connective tissue disorders research
- Cellular Mechanics and Interactions
- Muscle Physiology and Disorders
- Oral microbiology and periodontitis research
- Bone health and treatments
- TGF-β signaling in diseases
- Oral and gingival health research
- Platelet Disorders and Treatments
- Meat and Animal Product Quality
- Hemophilia Treatment and Research
- Immune Response and Inflammation
- Tissue Engineering and Regenerative Medicine
- Signaling Pathways in Disease
- Tribology and Lubrication Engineering
- Sports injuries and prevention
- Glycosylation and Glycoproteins Research
The University of Melbourne
2016-2025
Boston University
2024
Australian Centre for Disease Preparedness
2017
Agricultural Institute
2017
Monash University
2013
Royal Veterinary College
1994-1997
The Christie Hospital
1996
Addenbrooke's Hospital
1992-1994
University of Cambridge
1993
Wake Forest University
1993
The distribution of the extracellular matrix glycoprotein, tenascin, in normal skin and healing wounds rats, has been investigated by immunohistochemistry. In skin, tenascin was sparsely distributed, predominantly association with basement membranes. wounds, there a marked increase expression at wound edge all levels skin. There also particularly strong staining dermal-epidermal junction beneath migrating, proliferating epidermis. Tenascin present throughout granulation tissue, which filled...
The tissue distribution of the extracellular matrix glycoprotein, tenascin, during cartilage and bone development in rodents has been investigated by immunohistochemistry. Tenascin was present condensing mesenchyme anlagen, but not surrounding mesenchyme. In fully differentiated cartilages, tenascin only perichondrium. bones that form endochondral ossification, reappeared around osteogenic cells invading model. also developing intramembranous ossification later spicules forming bone. absent...
Tenascin is an extracellular matrix glycoprotein that not present in the normal mature rat mammary gland. The distribution of tenascin was examined by immunohistochemistry tumors from carcinogen-treated and untreated rats, virus-induced mice, a variety gland lesions humans. detectable stroma malignant but benign all species. An inhibition ELISA, testing homogenates tumors, confirmed tumors. Thus, consistently found to be stromal marker for epithelial malignancy It concluded may involved...
Abstract The distribution of the extracellular matrix (ECM) glycoprotein, tenascin, has been compared with that fibronectin in neural crest migration pathways Xenopus laevis, quail and rat embryos. In all species studied, examined by immunohistochemistry, was more closely correlated than fibronectin, which is known to be important for migration. laevis embryos, anti-tenascin stained dorsal fin ECM along ventral route migration, but not found laterally between ectoderm somites where cells do...
ABSTRACT Periodontitis is a chronic inflammatory disease affecting oral tissues. Oral epithelial cells represent the primary barrier against bacteria causing disease. We examined responses of such to an arginine-specific cysteine proteinase (RgpB) produced by causative agent periodontal disease, Porphyromonas gingivalis . This protease caused intracellular calcium transient in cell line (KB), which was dependent on its enzymatic activity. Since protease-activated receptors (PARs) might...
Gonadal function was assessed in 101 postpubertal subjects after chemotherapy for childhood Hodgkin's disease. All had received ChlVPP (chlorambucil, vinblastine, procarbazine, and prednisolone) alone, with no radiotherapy below the diaphragm. Gonadotropin levels were available 46 (79.3%) male 32 (74.4%) female subjects. The mean age at diagnosis cohort 12.2 years (range 8.2-15.3) females 13.0 (9.0-15.2). males studied a median of 6 2.5-11.1) 4.3 1.9-11.5) from diagnosis, respectively....
ABSTRACT Tenascin is an extracellular matrix molecule that was earlier shown to be enriched in embryonic mesenchyme surrounding the budding epithelium various organs including tooth. In present study tenascin localized by immunohistology throughout course of tooth development mouse and rat using polyclonal antibodies against chick tenascin. The results indicate expressed lineage dental mesenchymal cells ontogeny. intensity staining with papilla temporarily reduced at cap stage when grows...
Gingipain‐R, the major arginine‐specific proteinase from Porphyromonas gingivalis , a causative agent of adult periodontal disease, was found to cleave model peptide representing cleavage site proteinase‐activated receptor‐2 (PAR‐2), G‐protein‐coupled receptor on surface neutrophils. The bacterial also shown induce an increase in intracellular calcium concentration enzyme‐treated neutrophils, most probably due PAR‐2 activation. This response by neutrophils gingipain‐R may be mechanism for...
ABSTRACT The glycoprotein tenascin is found in the extracellular matrix regions of cell motility, proliferation, and tissue modelling. We have used novel cDNA probes to localize transcripts developing mouse study regulation expression by growth factors vitro. At postnatal day 1 mRNAs are abundant bone cartilage formation, as well ependymal layer central nervous system. Previous studies demonstrated that transforming factor-β type (TGF-β1) can induce As TGF-β1 absent or scarce brain, it...
Cells that form bone (osteoblasts) express both ephrinB2 and EphB4, previous work has shown pharmacological inhibition of the eph-rinB2/EphB4 interaction impairs osteoblast differentiation in vitro vivo. The purpose this study was to determine role signaling lineage process formation. Cultured osteoblasts from mice with osteoblast-specific ablation showed delayed expression markers, a finding reproduced by ephrinB2, but not RNA interference. Microcomputed tomography, histomorphometry,...
Microdamage accumulation leads to subchondral bone injury and/or fracture in racehorses. An understanding of this process is essential for developing strategies prevention.To quantify microdamage the third metacarpal Thoroughbred racehorses at different stages training cycle.Cross-sectional.Bone blocks from palmar aspect medial condyles bones 46 racing horses undergoing post-mortem were examined with micro computed tomography (microCT) detect calcified microcracks, and light microscopy bulk...
Abstract Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until remodeled. The interconnected osteocyte network within the matrix differentiates from bone-forming osteoblasts; although osteoblast differentiation requires EphrinB2, osteocytes retain its expression. Here we report brittle bones in mice with osteocyte-targeted EphrinB2 deletion. not caused by low...