A5060038619- Bone health and treatments
- Synthesis and Characterization of Heterocyclic Compounds
- Bone Metabolism and Diseases
- Genomics, phytochemicals, and oxidative stress
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Cholinesterase and Neurodegenerative Diseases
- Osteoarthritis Treatment and Mechanisms
- Natural Antidiabetic Agents Studies
- Synthesis and biological activity
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Medicinal Plants and Neuroprotection
- Neuroinflammation and Neurodegeneration Mechanisms
- Essential Oils and Antimicrobial Activity
- Single-cell and spatial transcriptomics
- Cytokine Signaling Pathways and Interactions
- Chemotherapy-induced cardiotoxicity and mitigation
- Bone and Dental Protein Studies
- Gene Regulatory Network Analysis
- Cell death mechanisms and regulation
- Alzheimer's disease research and treatments
- Nuclear Receptors and Signaling
- Hip disorders and treatments
- Medicinal Plants and Bioactive Compounds
Monash University
2019-2023
The University of Melbourne
2017-2022
Tabriz University of Medical Sciences
2021-2022
St Vincent's Hospital
2017-2020
St Vincents Institute of Medical Research
2017-2020
Shahid Beheshti University of Medical Sciences
2010-2013
Tehran University of Medical Sciences
2010-2011
University of Mississippi Medical Center
1998
Alzheimer's disease (AD) is the most common neurodegenerative disorder to date, with no curative or preventive therapy. Histopathological hallmarks of AD include deposition β-amyloid plaques and formation neurofibrillary tangles. Extent studies on pathology have made important discoveries regarding mechanism potential therapeutic targets. Many cellular changes including oxidative stress, disruption Ca2+ homeostasis, inflammation, metabolic disturbances, accumulation unfolded/misfolded...
Abstract Mineralized bone forms when collagen-containing osteoid accrues mineral crystals. This is initiated rapidly (primary mineralization), and continues slowly (secondary mineralization) until remodeled. The interconnected osteocyte network within the matrix differentiates from bone-forming osteoblasts; although osteoblast differentiation requires EphrinB2, osteocytes retain its expression. Here we report brittle bones in mice with osteocyte-targeted EphrinB2 deletion. not caused by low...
ABSTRACT Parathyroid hormone–related protein (PTHrP) and parathyroid hormone (PTH) have N-terminal domains that bind a common receptor, PTHR1. PTH (teriparatide) now modified PTHrP (abaloparatide) are US Food Drug Administration (FDA)-approved therapies for osteoporosis. In physiology, does not normally circulate at significant levels, but acts locally, osteocytes, cells residing within the bone matrix, express both Because PTHR1 in osteocytes is required normal resorption, we determined how...
We report the design of dual pH-responsive multicomponent nanoparticles with tunable core polymer architectures to understand how architecture affects intracellular therapeutic delivery. Star and linear polymers were synthesized using charge shifting monomers, anticancer drug doxorubicin (Dox) covalently conjugated via hydrazone linkages. Nanoparticles comprising either a star or designed by self-assembly an amphiphilic block copolymer. Despite similar physicochemical properties, displayed...
AbstractCa2+ is an essential second messenger, playing a fundamental role in maintaining cell viability and neuronal activity. Two specific endoplasmic reticulum calcium channels, ryanodine receptors (RyRs) inositol 1,4,5-trisphosphate (IP3Rs) play important Ca2+ regulation. In the present study, we provided 3D structure of RyR IP3R by homology modeling, predicted their interactions with known neuroprotective compound, 3-thiomethyl-5,6-(dimethoxyphenyl)-1,2,4-triazine (TDMT), as well two...
This study was designed to examine antioxidant activities, antiglycating abilities and neuroprotective effects of methanolic extracts Salvia choloroleuca, santolinifolia mirzayanii from Iran. The were screened for their possible activities by several biochemical assays such as DPPH, FRAP, β-carotene bleaching TEAC assays. HPLC analysis these led the separation a number components catechine rosmarinic acid. Based on our results, all plants had among them S. choloroleuca seems be most...
There is mounting evidence implicating the role of oxidative stress induced by reactive oxygen species (ROS) in neurodegenerative disease, including Alzheimer's disease. Herein we investigated neuroprotective potential a natural flavonoid, calycopterin, against H(2)O(2)-induced cell death differentiated PC12 cells. We pretreated cells with 25, 50, and 100 μM calycopterin followed addition H(2)O(2) as an agent. measured viability MTT test found that 50 best protective concentration...
In the low intracellular chloride milieu, ions of cisplatin may exchange for cellular SH moieties resulting in glutathione depletion, H2O2 accumulation, and lipid peroxidation. Cisplatin-induced peroxidation, addition to causing direct injury, further contribute cisplatin-induced renal dysfunction by generating vasoconstrictive E2- F2-isoprostanes. The aim this study was determine whether epithelial (LLC-PK1 primary human proximal tubular) cell injury is associated with increased production...
Biological heterogeneity is a primary contributor to the variation observed in experiments that probe dynamical processes, such as internalization of material by cells. Given critical process which many therapeutics and viruses reach their intracellular site action, quantifying cell-to-cell variability high biological interest. Yet, it common for studies neglect variability. We develop simple mathematical model captures behaviour, variation, extrinsic noise introduced flow cytometry....
Much evidence supports that oxidative stress plays an important role in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease. Herein, we studied compensatory/adaptive mechanisms involved 3-thiomethyl-5,6-(diphenyl)-1,2,4-triazine and 3-thiomethyl-5,6-(dichlorophenyl)-1,2,4-triazine neuroprotection. We found these compounds could counteract H(2)O(2)-induced rupture neurite outgrowth differentiated PC12 cells. In addition, pretreatment cells with triazine derivatives...