A5100750145- Aquaculture disease management and microbiota
- Leptospirosis research and findings
- Veterinary medicine and infectious diseases
- Aquaculture Nutrition and Growth
- Crop Yield and Soil Fertility
- interferon and immune responses
- Toxoplasma gondii Research Studies
- Viral Infections and Vectors
- Bacterial Infections and Vaccines
- Atherosclerosis and Cardiovascular Diseases
- HIV Research and Treatment
- Bacillus and Francisella bacterial research
- Invertebrate Immune Response Mechanisms
- Bacterial biofilms and quorum sensing
- Immune cells in cancer
- Cancer Cells and Metastasis
- Complement system in diseases
- Biochemical and Structural Characterization
- Cancer Research and Treatments
- Echinoderm biology and ecology
- Antimicrobial Peptides and Activities
- Second Language Learning and Teaching
- Reproductive biology and impacts on aquatic species
- Yersinia bacterium, plague, ectoparasites research
- Peroxisome Proliferator-Activated Receptors
Zhengzhou University
2025
The Sixth People's Hospital of Zhengzhou
2025
Hebei Normal University of Science and Technology
2024
Shandong Academy of Sciences
2023
Qilu University of Technology
2023
National Institutes for Food and Drug Control
2017-2023
Peking University
2023
Shandong Provincial QianFoShan Hospital
2023
Shandong First Medical University
2023
Southwest University
2022
Background: The protumor activities of cancer-associated fibroblasts (CAFs) suggest that they are potential therapeutic targets for the treatment cancer. mechanism CAF heterogeneity in gastric cancer (GC) remains unclear and has slowed translational advances targeting CAFs. Therefore, a comprehensive understanding classification, function, activation stage, spatial distribution subsets GC is urgently needed. Methods: In this study, characteristics dynamic communication among tumor...
The wheat scab caused by Fusarium graminearum (F. graminearum) has seriously affected the yield and quality of in China. In this study, gallic acid (GA), a natural polyphenol, was used to synthesize three azole-modified derivatives (AGAs1–3). antifungal activity GA its against F. studied through mycelial growth rate experiments field efficacy experiments. results test showed that EC50 AGAs–2 0.49 mg/mL, AGAs–3 0.42 mg/mL. biological on is significantly better than GA. tests reduced incidence...
Traditional lipoarabinomannan tests have limited sensitivity in HIV-negative individuals. Our aims were to compare chemiluminescence-based LAM (AIMLAM) and other diagnostic modalities patients explore whether lymphocyte counts impact the costs of AIMLAM. This is a prospective, cross-sectional, accuracy study. Participants underwent testing with sputum acid-fast bacilli, culture, GeneXpert, Their efficiency cost-effectiveness alone or under different count categories was evaluated. Using MRS...
Leptospirosis, caused by pathogenic Leptospira spp., is recognized as an important emerging zoonotic disease throughout the world. In this study, multiple approaches were used to characterize recently discovered serovar Heyan strain L231. This can infect guinea pigs and belonged species L. weilii. Genome sequencing analysis revealed draft genome of 4.2 M bp with a G+C content 40.67% for L231, total 4,794 ORFs identified. The L231 was found have larger LPS biosynthesis locus than that strains...
The RNA interference (RNAi) pathway directs an important antiviral immunity mechanism in plants and invertebrates. Recently, we others have demonstrated that the RNAi response is also conserved mammals, at least to five distinct viruses, including Zika virus (ZIKV). ZIKV may preferentially infect neuronal progenitor cells (NPCs) developing foetal brain. Ex vivo infection induces RNAi-mediated human NPCs, but not more differentiated NPCs or somatic cells. However, litter known about property...
We compared several identification methods for Aeromonas genus members, including traditional biochemical testing, multiplex-PCR amplification, mass spectrometry identification, whole-genome sequencing, multilocus phylogenetic analysis (MLPA), and rpoD, gyrA , rpoD - gene sequencing. Isolates ( n = 62) belonging to the genus, which were came from bacterial bank in laboratory, used assess accuracy of different methods. Whole-genome sequencing showed that spp. isolates comprised A. caviae 21),...
A 70-day experiment was conducted to investigate the effects of mulberry leaf extract (MLE) on growth, proximate compositions, antioxidant and plasma biochemical parameters, indices non-specific immunity largemouth bass ( Micropterus salmoides ) fed a high-starch diet. Two hundred eighty (initial body weight, 68.00 ± 0.19 g) were randomly seven diets: basal-starch diet (BSD; 8.88% starch), (HSD; 11.42% HSD diets supplemented with 0.05%, 0.10%, 0.20%, 0.50%, 1.00% MLE (MLE1, MLE2, MLE3, MLE4,...
Leptospirosis is one of the most important but neglected, infectious tropical diseases worldwide. Leptospira interrogans now recognized as a leading cause disease. Little known genetic diversity and phylogenetic characteristics L. within China. To better understand transmission populations, we characterized 271 isolates seven vaccine strains from China during 1954–2014 using multilocus variable-number tandem repeat analysis (MLVA). 110 different MLVA profiles (MTs) were identified, which...
Background: Many studies have revealed a protective effect of infection with simian immunodeficiency virus (SIV) or simian-human (SHIV) against subsequent by related virus. However, whether response can be induced an is still currently debated in the HIV-1 vaccine field. The aim this study was to evaluate protection SHIV challenge Chinese macaques that had been inoculated SHIVs containing different envelops. Methods: Eleven adult rhesus monkeys were SHIV-KB9, SHIV-1157ipd3N4 SHIV-CN97001....
The macrolides-resistant Bordetella pertussis (MR-Bp) isolates in China evolved from the ptxP1/fhaB3 allele and rapidly became predominant, suggestive of an adaptive transmission ability. This was different global prevalent ptxP3 strains, which MR-Bp rarely reported. study aimed to determine underlying mechanism responsible for fitness resistance these two strains. We identify proteomic differences between ptxP3/fhaB1 strains using tandem mass tag (TMT)-based proteomics. then performed...
The purpose of this study was to investigate the effects dietary acetoin on Largemouth Bass (Micropterus salmoides). In 45 d farming, experimental diets were supplemented with 0%, 0.3%, 0.6%, and 0.9% levels, respectively. Results showed that activities lipase (LPS), amylase (AMS), trypsin in fish fed at 0.6% displayed most obvious improvement compared other levels ( <math xmlns="http://www.w3.org/1998/Math/MathML" id="M1"> <mi>P</mi> <mo><</mo> <mn>0.05</mn> </math> ). Furthermore,...
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In this study, the complete mitochondrial genome of Salmacis sphaeroides variegate was determined on Illumina HiSeq platform. The 15,770 bp in size and contains 22 tRNA genes, 13 protein-coding 2 rRNA 1 control region (180 bp). composition A + T S. mtDNA 61.90%. Except ND6 6 tRNAs, others are H-strand. phylogenetic relationships 11 species sea urchins were analyzed using neighbor-joining method software MEGA 7.0. most closely related to Temnopleurus hardwickii.
Objective To observe the treatment effects in 48 cases of advanced lung cancer patients,with immune therapy dendritic cells loading tumor autologous antigen (DCTAA) combining with induced factor killer (CIK) from matched umbilical cord blood cells. Methods The peripheral mononuclear cell (PBMC) was seperated, and to CIK DC some cytokines vitro, such as CD3McAb, IL-2, IFN-γ IL-1α, etc. After 12 15 days, amplified obtained were obtained, strict quality control, infused patients body back six...
Abstract The macrolides-resistant Bordetella pertussis (MR- Bp ) isolates in China evolved from the ptxP1/fhaB3 allele and rapidly became predominant, suggestive of an adaptive transmission ability. This was different global prevalent ptxP3 strains, which MR- rarely reported. study aimed to determine underlying mechanism responsible for fitness resistance these two strains. We identify proteomic differences between ptxP3/fhaB1 strains using TMT-based proteomics. then performed in-depth...