A5071367558- Endometriosis Research and Treatment
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Reproductive System and Pregnancy
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Sperm and Testicular Function
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Growth Hormone and Insulin-like Growth Factors
- Reproductive Health and Technologies
- Omental and Epiploic Conditions
- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Prenatal Screening and Diagnostics
- Thyroid Disorders and Treatments
- Tissue Engineering and Regenerative Medicine
- Reproductive Physiology in Livestock
- Gestational Trophoblastic Disease Studies
- Hops Chemistry and Applications
- Tuberous Sclerosis Complex Research
- Metabolism and Genetic Disorders
- Systemic Lupus Erythematosus Research
- Water-Energy-Food Nexus Studies
New Hope Fertility Center
2025
Asan Medical Center
2009-2018
University of Ulsan
2009-2018
Ulsan College
2006-2018
Eulji University
2016-2018
Good Moonhwa Hospital
2015
We performed the present prospective case-control study to evaluate whether plasma concentrations of phthalate esters are elevated in women with advanced-stage endometriosis a Korean population. Measuring levels monoethylhexyl and di-(2-ethylhexyl) 97 169 control by liquid chromatography–tandem mass spectrometry, we found that phthalate, as well significantly higher those endometriosis, which supports hypothesis exposure might play role establishment endometriosis. There is growing evidence...
Although phthalates were shown to have several negative effects on reproductive function in animals, its role the pathogenesis of endometriosis remains be elucidated.We aimed investigate vitro and vivo di-(2-ethylhexyl)-phthalate (DEHP) compare urinary levels phthalate metabolites between women with without endometriosis.For experimental studies, we used endometrial cell culture nonobese diabetic/severe combined immunodeficiency (NOD/SCID) mouse models. We also performed a prospective...
Objective To evaluate the efficacy and safety of dienogest treatment in patients who had received for 12 months or more to treat endometriosis. Methods We analyzed clinical data 188 women with endometriosis been treated 2 mg once a day at single institute. evaluated changes endometriosis-associated pain endometrioma size, recurrence rate, adverse events following administration. Bone mineral density (BMD) was measured were prescribed than 18 months. Results Pain significantly reduced after...
Objective To evaluate the effect of progesterone supplementation during luteal phase on pregnancy outcome in natural frozen-thawed embyo transfer (FTET) cycles. Methods In this retrospective cohort study, 228 consecutive patients who underwent FTET cycles between January 2009 and September 2012 were included. One hundred forty-five received support (P group) but 83 did not receive any (control group). Results There no differences patients' characteristics two groups. The groups similar with...
This study was performed to investigate the effect of transdermal testosterone gel (TTG) on controlled ovarian stimulation (COS) and IVF outcomes morphology according pretreatment duration in poor responders. A total 120 women were recruited for this pilot study. They randomized into control, 2 weeks, 3 weeks or 4 TTG treatment groups. For three groups, 12.5 mg applied daily preceding period cycle. After pretreatment, significant increase antral follicle count (AFC) decreases mean follicular...
Does interleukin-32 (IL-32) play a role in the pathogenesis of endometriosis?IL-32 might be involved endometriosis through increased viability, proliferation and invasion endometrial cells.Endometriosis is characterized as chronic inflammatory disease several proinflammatory cytokines are suggested to its pathophysiology. IL-32, recognized new cytokine strong inducer other cytokines, has been shown serve key modulator diseases.This study included comparison IL-32 levels peritoneal fluids...
Problem We evaluated whether the expression of NF ‐кB p65 subunit is increased in eutopic endometrium and/or ovarian endometrioma women with advanced stage endometriosis, and ascertained vitro effects proinflammatory cytokines on DNA binding endometrial cells. Method Study Immunohistochemistry was performed to compare nuclear immunoreactivity between without endometriosis. The were also analyzed cells treated tumor necrosis factor‐alpha ( TNF ‐α) or interleukin‐1beta IL ‐1β) utilizing...
Endometriosis is defined as the presence of functional endometrial tissue outside uterus, causing diverse progressive symptoms such infertility, pelvic pain, and dysmenorrhea. Although endometriosis has been described since 1800s, mechanisms responsible for its pathogenesis progression remain poorly understood. It well established that grows regresses in an estrogen-dependent fashion disease can be effectively cured by definitive surgery. However, prolonged medical therapy may needed most...
Objective To investigate the effectiveness of GnRH antagonist multiple-dose protocol (MDP) with oral contraceptive pill (OCP) pretreatment in poor responders undergoing IVF/ICSI, compared MDP without OCP and agonist low-dose long (LP). Methods A total 120 were randomized into three groups according to controlled ovarian stimulation (COS) options; after (group 1), 2) or luteal LP 3). Patients allocated group 1 pretreated for 21days cycle preceding COS, using recombinant human FSH (rhFSH) was...
Abstract Objective : To investigate if the immunotherapy with corticosteroids would improve pregnancy rate in infertile patients endometriosis who undergo vitro fertilization and embryo transfer (IVF‐ET). Methods Forty‐two plus tubal factor 87 pure infertility underwent IVF‐ET our unit were allocated randomly to corticosteroid treatment group control group. Results The prevalence of autoantibodies (antinuclear antibody, lupus anticoagulant, anticardiolipin rheumatoid factor) was elevated...
Objective To investigate the effects of pioglitazone on controlled ovarian stimulation (COS), IVF outcomes, and follicular fluid (FF) cytokine concentrations in patients with polycystic ovary syndrome (PCOS). Methods Eighty-six infertile PCOS resistant to clomiphene citrate were randomized receive (30 mg/day) or placebo starting day oral contraceptive (OC) pretreatment, followed by an protocol using a GnRH antagonist. Pioglitazone was administered once daily from OC hCG injection. Results...
With improved survival rates among cancer patients, fertility preservation is now being recognized as an issue of great importance. There are currently several methods available in female patients and the options techniques via assisted reproduction cryopreservation increasing, but some still experimental continues to be evaluated. The established means preserving include embryo cryopreservation, gonadal shielding during radiation therapy, ovarian transposition, conservative gynecologic...
Objective To evaluate whether letrozole incorporated in a gonadotrophin-releasing hormone (GnRH) antagonist multiple dose protocol (MDP) improved controlled ovarian stimulation (COS) and vitro fertilization (IVF) results poor responders who underwent IVF treatment. Methods In this retrospective cohort study, total of 103 consecutive cycles that were performed during either the letrozole/GnRH MDP (letrozole group, n=46) or standard GnRH (control n=57) included responders. COS outcomes...
Problem The intracellular antioxidant system, based on glutathione (GSH), plays a key role in endometrial detoxification reactions and has been proposed to be involved the pathogenesis endometriosis. This study was designed evaluate whether estradiol (E 2 ) proinflammatory cytokines have any effects expression of stromal cells (ESCs). Method Glutathione levels were measured utilizing high‐performance liquid chromatography following vitro culture treatment ESCs with estradiol, tumor necrosis...