A5052972795- Wound Healing and Treatments
- Skin and Cellular Biology Research
- Cellular Mechanics and Interactions
- Autoimmune Bullous Skin Diseases
- Antimicrobial agents and applications
- Antimicrobial Peptides and Activities
- Bacterial biofilms and quorum sensing
- Nanoparticles: synthesis and applications
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Tendon Structure and Treatment
- Burn Injury Management and Outcomes
- Dermatologic Treatments and Research
- Graphene and Nanomaterials Applications
- Cell Adhesion Molecules Research
- Electrospun Nanofibers in Biomedical Applications
- Cutaneous lymphoproliferative disorders research
- Silk-based biomaterials and applications
- Advanced Nanomaterials in Catalysis
- Proteoglycans and glycosaminoglycans research
- Psoriasis: Treatment and Pathogenesis
- Diabetic Foot Ulcer Assessment and Management
- Bee Products Chemical Analysis
- Biochemical and Structural Characterization
- Fibroblast Growth Factor Research
University of South Australia
2016-2025
The University of Adelaide
2007-2024
University of Bath
2022
University of Newcastle Australia
2022
Monash University
2022
Women's and Children's Hospital
2019
Women's & Children's Health Research Institute
2007-2013
South Australia Pathology
2012
NeuroSurgical Research Foundation
2012
Government of Western Australia Department of Health
2011
Ultrasmall silver nanoparticles (AgNPs; size < 3 nm) have attracted a great deal of interest as an alternative to commercially available antibiotics due their ability eliminate wide range microbial pathogens. However, most these ultrasmall AgNPs are highly reactive and unstable, well susceptible fast oxidation. Therefore, both the stability toxicity remain major shortcomings for clinical application uptake. To circumvent problems, we present novel strategy impregnate into biocompatible...
Persistent wound infections have been a therapeutic challenge for long time. Current treatment approaches are mostly based on the delivery of antibiotics, but these not effective all infections. Here, we report development sensitive pH-responsive hydrogel that can provide controlled, pH-triggered release silver nanoparticles (AgNPs). This system was designed to sense environmental pH and trigger AgNPs when changes from acidic alkaline, as occurs due presence pathogenic bacteria in wound. Our...
Antibacterial treatment that provides on-demand release of therapeutics can kill a broad spectrum pathogens while maintaining long-term efficacy and without developing resistance or causing side effects is urgently required in clinical practice. Here, we demonstrate the development multistimuli-responsive hydrogel, prepared by cross-linking N-isopropylacrylamide with acrylic acid loaded ultrasmall silver nanoparticles (AgNPs), offering Ag+ ions triggered changes wound microenvironment. We...
Silver-based nano-antibiotics are rapidly developing as promising alternatives to conventional antibiotics. Ideally, remain potent against a wide range of drug-resistant and anaerobic bacteria, silver-based should easily penetrate through the bacterial cell walls actively release silver ions. In this study, highly monodispersed, ultrasmall (<3 nm), polycationic nanoclusters (pAgNCs) designed synthesized for elimination common Gram-negative Gram-positive pathogens their corresponding...
Gel-based wound dressings have gained popularity within the healthcare industry for prevention and treatment of bacterial fungal infections. Gels based on deep eutectic solvents (DESs), known as eutectogels, provide a promising alternative to hydrogels they are non-volatile highly tunable can solubilize therapeutic agents, including those insoluble in hydrogels. A choline chloride:glycerol-cellulose eutectogel was loaded with numerous antimicrobial agents silver nanoparticles, black...
Biofilm-associated infections are a major cause of impaired wound healing. Despite the broad spectrum anti-bacterial benefits provided by silver nanoparticles (AgNPs), these materials still controversy due to cytotoxicity and lack efficacy against mature biofilms. Herein, highly potent ultrasmall AgNPs were combined with biocompatible hydrogel integrated synergistic functionalities facilitate elimination clinically relevant biofilms in-vivo improved healing capacity. The delivery platform...
Infection of burn wounds often leads to poor healing, sepsis, disability, or even death. Traditional care focuses on early debridement, fluid resuscitation, and intravenous antibiotics but these are inadequate due compromised vasculature limiting systemic effectiveness. Biofilms in barriers treatment associated with the transition from acute chronic non-healing state. Current topical treatments for include skin substitutes impregnated stem cells that promote healing; hydrogels delivering an...
Burn wounds trigger prolonged inflammation, impair healing, and result in a high mortality rate. The effective management of burn patients requires targeted approach to regulate the wound microenvironment, maintaining sterility while fostering conditions conducive healing functionality. Here, we developed antibacterial pH/temperature-responsive silver nanoparticle (AgNP) hydrogel triggering release ions based on changes microenvironment. delivery system not only exerts strong effect owing...
Advances in wearable, highly sensitive and multifunctional strain sensors open up new opportunities for the development of wearable human interface devices various applications such as health monitoring, smart robotics therapy. Herein, we present a simple cost-effective method to fabricate sensor consisting skin-mountable dry adhesive substrate, robust sensing component transdermal drug delivery system. The has high piezoresisitivity monitor real-time signals from finger bending ulnar pulse....
Abstract Current treatment modalities of cutaneous wound infections are largely ineffective, attributed to the increasing burden antimicrobial resistance. S. aureus , a commonly wound‐associated pathogen continues pose clinical challenge, suggesting that new alternative therapeutic materials urgently required provide optimal treatment. A layered allotrope phosphorus termed Black Phosphorus nanoflakes (BPNFs) has emerged as potential antibacterial material. However, wider deployment this...
Collagen type I serves as an abundant structural and signalling component of skin. It is also established target gene the transcription factor, c-Myb. When c-myb-/- embryos were examined it was observed that their skin markedly thinner than normal. Importantly, immunohistochemical investigation showed complete absence collagen I. Although these homozygous knock-out fail to develop beyond day 15, fibroblasts from (mouse embryonic [MEFs]) show defective proliferative responses. Furthermore, in...
Abstract Epidermolysis bullosa (EB) is a severe genetic skin fragility syndrome characterized by blister formation. The molecular basis of EB still largely unknown and wound healing in patients suffering from remains major challenge to their survival. Our previous studies have identified the actin remodelling protein Flightless I (Flii) as an important mediator repair. Here we identify Flii novel target involved blistering. expression was significantly elevated 30 with EB, most prominently...
Silver nanoparticles (AgNPs) have attracted enormous interest because of their excellent antibacterial properties, low cytotoxicity and limited evidence for resistance. As a general trend, smaller are considered to stronger activity. In this work we investigate whether trend is valid the sub-10 nm region by designing synthesising three types AgNPs (∼1.87, ∼2.93 ∼6.53 nm) reveal influence size, valence state structure on potency AgNPs. We found that NPs with size having high concentration...
Abstract Wound healing is an important area of widely unmet medical need, with millions procedures carried out worldwide which could potentially benefit from a product to improve the wound repair process. Our studies investigating actin‐remodeling protein F lightless I ( Fl ii) show it be regulator healing. lii‐deficient mice have enhanced in comparison lii overexpressing impaired For first time, we that neutralizing monoclonal antibody FnAb ) therapy effective large animal model repair....