A5085795136- Trace Elements in Health
- Heavy Metal Exposure and Toxicity
- Radioactivity and Radon Measurements
- Nuclear Physics and Applications
- Heavy metals in environment
- Radioactive element chemistry and processing
- Vanadium and Halogenation Chemistry
- Analytical chemistry methods development
- Heavy Metals in Plants
- Nanoparticles: synthesis and applications
- Chromium effects and bioremediation
- Contact Dermatitis and Allergies
- X-ray Spectroscopy and Fluorescence Analysis
- Thallium and Germanium Studies
- Mercury impact and mitigation studies
- Occupational and environmental lung diseases
- Extraction and Separation Processes
- Radiopharmaceutical Chemistry and Applications
- Occupational exposure and asthma
- Carcinogens and Genotoxicity Assessment
- Immunotoxicology and immune responses
- Pharmacological Effects and Toxicity Studies
- Chemical Synthesis and Characterization
- Environmental Toxicology and Ecotoxicology
- Heme Oxygenase-1 and Carbon Monoxide
Polytechnic University of Turin
2024-2025
University of Chieti-Pescara
2007-2015
University of Milan
1996-2015
Veneto Nanotech (Italy)
2015
Istituto Nazionale di Fisica Nucleare, Laboratori Acceleratori e Superconduttività Applicata
2015
Joint Research Centre
1997-2011
University Foundation
2007
European Commission
1983-2007
Fondazione "Ugo Bordoni"
2001
European Union
1993
Owing to the increasing development of nanotechnology, there is a need assess how engineered nanomaterials can interact with living cells. The main purpose present study was whether metal cobalt nanoparticles (CoNP 100–500 nm) are genotoxic compared ions (Co2+). Uptake experiments were carried out by incubating peripheral blood leukocytes (PBLs) 57Co2+ (added stable Co2+ 10−2 M obtain concentrations in range 10−5 10−4 M) or 60CoNP for 24 and 48 h. Whereas intracellular showed slight no...
Cytotoxicity, morphological transformation and cellular retention have been studied in BALB/3T3 Cl A 31-1-1 cells for ammonium or sodium vanadate [vanadium(V)] vanadyl sulphate [vanadium(IV)]. focus assay showed transforming activity vanadium(V) (P less than 0.005 at concentrations of 3 x 10(-6) higher) while vanadium(IV) was not the cells. Cytotoxicity higher vanadium(IV); this particularly clear doses from 5 to 10(-5) M. The both compounds 24, 48 72 h incubation similar. At lower M...
Particulate matter is associated with different human diseases affecting organs such as the respiratory and cardiovascular systems. Very small particles (nanoparticles) have been shown to be rapidly internalized into body. Since sites of internalization location detected are often far apart, a distribution via blood stream must occurred. Thus, endothelial cells, which line inner surface vessels, had direct contact particles. In this study we tested effects metallic nanoparticles (Co Ni) on...
Sample collection guidelines for trace elements in blood and urine SynopsisThis paper presents an organized system element-specific sample handling of human (whole blood, serum or plasma, packed cells erythrocytes) also indicating a proper definition the subject sample.Harmonized procedures collection, preparation, analysis quality control are suggested.The aim is to assist scientists worldwide produce comparable data which will be useful on regional, national international scale.The...
This work focuses on the analysis of genotoxic effects human peripheral lymphocytes exposed in vitro to different arsenic (As) compounds by means cytokinesis-block micronucleus assay. The study was carried out challenging with six As trivalent or pentavalent forms such as arsenite (As(III)) and arsenate (As(V)) organoarsenic species monomethylarsonous acid (MMAs(III)), monomethylarsonic (MMAs(V)), dimethylarsinic (DMAs(V)) trymethylarsine oxide (TMAO(V)). For As(III) As(V) at concentrations...
Rabbits were treated with single doses of 50 micrograms AsO2-/kg b.w. by IP injection. At 48 h, 83.0 +/- 2.1% arsenic is excreted via the urine. Also in blood clearance rapid. Liver, kidney, and lung, among tissues tested, show highest concentration at 5, 16, h after Arsenic was found to be present subcellular levels mainly nuclear soluble fractions above-mentioned tissues. Chromatographic studies performed gel filtration have shown that plasma lung cytosol, present, associated low molecular...
ABSTRACT We propose a MANOVA test for semicontinuous data that is applicable also when the dimension exceeds sample size. The statistic obtained as likelihood ratio, where numerator and denominator are computed at maxima of penalized functions under each hypothesis. Closed form solutions regularized estimators allow us to avoid computational overheads. derive null distribution using permutation scheme. power level resulting evaluated in simulation study. illustrate new methodology with two...