A5102869144- Renal Diseases and Glomerulopathies
- Calpain Protease Function and Regulation
- Pulmonary Hypertension Research and Treatments
- Signaling Pathways in Disease
- PI3K/AKT/mTOR signaling in cancer
- Mesenchymal stem cell research
- Cystic Fibrosis Research Advances
- Pharmacological Effects of Natural Compounds
- Neurological Disorders and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Epigenetics and DNA Methylation
- Chronic Kidney Disease and Diabetes
- Fungal Biology and Applications
- Immune cells in cancer
- Neurological Disease Mechanisms and Treatments
- MicroRNA in disease regulation
- Natural Compounds in Disease Treatment
- Endoplasmic Reticulum Stress and Disease
- Adipose Tissue and Metabolism
- Cell death mechanisms and regulation
- Cardiac Fibrosis and Remodeling
- RNA Research and Splicing
- TGF-β signaling in diseases
- COVID-19 Clinical Research Studies
- Platelet Disorders and Treatments
Chengdu University of Traditional Chinese Medicine
2014-2024
Zhejiang Chinese Medical University
2019-2024
Maternal and Child Health Hospital of Xinjiang Uygur Autonomous Region
2022-2024
Chengdu University
2020-2024
Zhejiang University
2008-2024
Zhejiang Center for Disease Control and Prevention
2022-2024
Henan University
2021-2023
Hangzhou Hospital of Traditional Chinese Medicine
2018-2023
Henan Provincial People's Hospital
2020-2023
Beijing University of Chinese Medicine
2023
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Emerging evidence suggests an association between remnant cholesterol (RC) and vascular damage hypertension. However, this has not been explored in a large-scale population China, temporal relationship RC hypertension also needs to be investigated.We conducted retrospective cross-sectional study 2,199,366 individuals longitudinal 24,252 with repeated measurements of lipid profile blood pressure at least 3-year follow-up. The logistic model was used explore the components analysis. Cox...
γδ T cells represent an evolutionarily primitive cell subset characterized by distinct TCRs and innate adaptive immune functions. However, the presence of this in ancient vertebrates remains unclear. In study, from a zebrafish (Danio rerio) model were subjected to molecular cellular characterizations. The constant regions TCR-γ (DrTRGC) δ (DrTRDC) initially identified. Zebrafish accounted for 7.7% 20.5% total lymphocytes spleen, head kidney, peripheral blood, skin, gill intestine tissues....
Coronavirus disease 2019 (COVID-19) pandemic continues to escalate intensively worldwide. Massive studies on general populations with SARS-CoV-2 infection have revealed that pre-existing comorbidities were a major risk factor for the poor prognosis of COVID-19. Notably, 49-75% COVID-19 patients had no comorbidities, but this cohort would also progress severe or even death. However, factors contributing progression and death in without chronic are largely unknown; thus, specific clinical...
Although epigenetic modulation is critical for a variety of cellular activities, its role in erythropoiesis remains poorly understood. Ten-eleven translocation (TET) molecules participate methylcytosine (5mC) hydroxylation, which results DNA demethylation several biological processes. In this research, the TETs was investigated by using zebrafish model, where three TET homologs were identified. These share conserved structural domains with their mammalian counterparts. Zebrafish mediate...
Long-term high-fat diet (HFD) induces both cardiac remodelling and myocardial dysfunction in murine models. The aim was to assess the time course mechanisms of metabolic modifications induced by short-term HFD wild-type (WT) mice. Thirty-three WT mice were subjected (60% fat, n = 16) chow (CD, 13% 17). Metabolic echocardiographic data collected at baseline every 5 weeks for 20 weeks. Invasive haemodynamic samples Echocardiographic included left ventricular (LV) diameters thickness, systolic...
Breast and lung cancers are the leading causes of mortality most frequently diagnosed in women men, respectively, worldwide.Although antitumor activity chalcones has been extensively studied, molecular mechanisms isoliquiritigenin analog 2', 4', 4-trihydroxychalcone (metochalcone; TEC) against carcinomas remain less well understood.In this study, we found that TEC inhibited cell proliferation breast cancer BT549 cells A549 a concentration-dependent manner.TEC induced cycle arrest S-phase,...
Objective— Carbon monoxide–releasing molecules (CORMs) represent a pharmacological alternative to CO gas inhalation. Here, we questioned whether CORM-3, well-characterized water-soluble CORM, could prevent and reverse pulmonary hypertension (PH) in chronically hypoxic mice smooth muscle promoter 22 serotonin transporter overexpressing the cells (SMCs). Approach Results— Treatment with CORM-3 (50 mg/kg per day once daily) for 3 weeks prevented PH, right ventricular hypertrophy, distal artery...
The microbiota is directly involved in the development and modulation of intestinal immune system. In particular, members genus Bifidobacterium play a primary role regulation. present study, bifidum H3-R2 was screened from 15 bifidobacterium strains by vitro experiment, showing positive tolerance to digestive tract conditions, adhesion ability epithelial cells regulatory effect on cell activity. Immunostimulatory activity B. also elucidated vivo cytoxan (CTX)-treated mice. results showed...
Decreasing the bioavailability of serotonin (5-HT) by inhibiting its biosynthesis may represent a useful adjunctive treatment pulmonary hypertension (PH). We assessed this hypothesis using LP533401, which inhibits rate-limiting enzyme tryptophan hydroxylase 1 (Tph1) expressed in gut and lung, without Tph2 neurons. Mice treated repeatedly with LP533401 (30–250 mg/kg per day) exhibited marked 5-HT content reductions gut, lungs, blood, but not brain. After single dose (250 mg/kg), lung contents...
Abstract Anisodamine hydrobromide (AniHBr) is a Chinese medicine used to treat septic shock. However, whether AniHBr could ameliorate acute kidney injury and the underlying mechanism were not investigated. In present study, 18 male Sprague-Dawley rats (200–250 g) randomly divided into control, lipopolysaccharide (LPS) LPS+AniHBr groups. Rats intravenously administrated with LPS or normal saline (for control). After 4 h, (LPS+AniHBr) at h intervals. Hemodynamic parameters including blood...
Proteinuria is an independent risk factor for the progression of diabetic nephropathy (DN) and imbalance in podocyte function aggravates proteinuria. Celastrol primary active ingredient T. wilfordii, effective treating DN renal injury; however, mechanisms underlying its effect are unclear. We explored how celastrol prevents damage using vivo vitro experiments. randomly divided 24 male C57BLKS/J mice into three groups: db/m (n = 8), db/db groups (db/db + celastrol, 1 mg/kg/d, gavage...
Significance Statement IgA nephropathy is the most common glomerulonephritis worldwide and a leading cause of kidney failure. The disease often progresses through episodes flare-ups that require effective treatments to tame inflammation. We followed rational design strategy construct recombinant fusion protease derived from commensal gut microbiota Clostridium ramosum . protease, referred as Fc-AK183, showed week-long activity in mice completely obliterate circulation clear pathologic...
Excessive growth of pulmonary arterial (PA) smooth muscle cells (SMCs) is a major component PA hypertension (PAH). The calcium-activated neutral cysteine proteases calpains 1 and 2, expressed by PASMCs, contribute to PH but are tightly controlled single specific inhibitor, calpastatin. Our objective was investigate calpastatin during (PH) progression its potential role as an intracellular and/or extracellular effector. We assessed in patients with idiopathic PAH mice hypoxic or spontaneous...
The activation of the calpain system is involved in repair process following myocardial infarction (MI). However, impact inhibition by calpastatin, its natural inhibitor, on scar healing and left ventricular (LV) remodeling elusive. Male mice ubiquitously overexpressing calpastatin (TG) wild-type (WT) controls were subjected to an anterior coronary artery ligation. Mortality at 6 wk was higher TG (24% WT vs. 44% TG, P < 0.05) driven a significantly incidence cardiac rupture during first week...
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Podocyte damage is common in many renal diseases characterized by proteinuria. Transient receptor potential cation channel protein 6 (TRPC6) plays an important role function through its regulation of intracellular Ca2+ influx and RhoA/ROCK pathways. Chinese herb Stephania tetrandra, with the main active component being tetrandrine, has been used for treatment various kidney several years shown a positive effect. This study aimed at investigating effect mechanism tetrandrine podocyte induced...
Podocyte injury or dysfunction can lead to proteinuria and glomerulosclerosis. Zonula occludens 1 (ZO-1) is a tight junction protein which connects slit diaphragm (SD) proteins the actin cytoskeleton. Previous studies have shown that expression of ZO-1 decreased in chronic kidney disease (CKD). Thus, elucidation regulation mechanism has considerable clinical importance. Triptolide (TP) been reported exert strong antiproteinuric effect by inhibiting podocyte epithelial mesenchymal transition...