A5065704987- Chemokine receptors and signaling
- Neuropeptides and Animal Physiology
- Oral and gingival health research
- Hedgehog Signaling Pathway Studies
- Oral and Maxillofacial Pathology
- Psoriasis: Treatment and Pathogenesis
- Cell Adhesion Molecules Research
- Glycosylation and Glycoproteins Research
- Asthma and respiratory diseases
- Dermatology and Skin Diseases
- Epigenetics and DNA Methylation
- Proteoglycans and glycosaminoglycans research
- Platelet Disorders and Treatments
- Antimicrobial Peptides and Activities
- Immune Cell Function and Interaction
Paracelsus Medical University
2019-2025
University of Salzburg
2020-2021
Abstract The regulatory peptide galanin is broadly distributed in the central- and peripheral nervous systems as well non-neuronal tissues, where it exerts its diverse physiological functions via three G-protein-coupled receptors (GAL 1-3 -R). Regulatory peptides are important mediators of cross-communication between nervous- immune have emerged a focus new therapeutics for variety inflammatory diseases. Studies on animal models cells revealed both pro- anti-inflammatory galanin. Here, we...
Adhesive properties of leukemia cells shape the degree organ infiltration and extent leukocytosis. CD44 integrin VLA-4, a CD49d/CD29 heterodimer, are important factors progenitor cell adhesion in bone marrow (BM). Here, we report their cooperation acute myeloid (AML) by novel non-classical CD44-mediated way inside-out VLA-4 activation. In primary AML BM samples from patients OCI-AML3 line, engagement hyaluronan induced activation resulting enhanced on VCAM-1. This was independent affinity...
Traumatic brain injury (TBI) is one of the world's leading causes death and disability in young individuals mechanism underlying TBI-associated neuroinflammation poorly understood. The regulatory neuropeptide galanin (GAL) its three receptors (GAL1-3R) are assumed to modulate neuroinflammatory response following TBI, especially by signalling via GAL2R GAL3R. Therefore, role GALRs acute functional recovery moderate Controlled Cortical Impact TBI was studied using GAL2/3R-double-KO...
Abstract Current research into neuropeptides is bringing to light many remarkable functions of these endocrine/neurocrine/paracrine factors, such as their roles in modulating immune responses. Galanin a neuropeptide expressed both neural and non‐neural tissues exerts its effects through three G protein–coupled receptors, GAL 1,2,3 ‐R. It has been demonstrated that galanin modulatory on cells, including neutrophils natural killer cells. Because monocytes express 2 ‐R, therefore are expected...
Psoriasis is an inflammatory skin disease characterized by increased neo-vascularization, keratinocyte hyperproliferation, a pro-inflammatory cytokine milieu and immune cell infiltration. Diacerein anti-inflammatory drug, modulating functions, including expression production of cytokines, in different conditions. Therefore, we hypothesized that topical diacerein has beneficial effects on the course psoriasis. The current study aimed to evaluate effect imiquimod (IMQ)-induced psoriasis...
(1) Background: Aberrant activation of the hedgehog (HH)—GLI pathway in stem-like tumor-initiating cells (TIC) is a frequent oncogenic driver signal various human malignancies. Remarkable efficacy anti-HH therapeutics led to approval HH inhibitors targeting key effector smoothened (SMO) basal cell carcinoma and acute myeloid leukemia. However, development drug resistance severe adverse effects SMO pose major challenges that require alternative treatment strategies HH—GLI TIC downstream SMO....
Abstract (1) Background Aberrant activation of the Hedgehog (HH)/GLI pathway in stem-like tumor initiating cells (TIC) is a frequent oncogenic driver signal various human malignancies. Remarkable efficacy anti-HH therapeutics led to approval HH inhibitors targeting key effector Smoothened (SMO) basal cell carcinoma and acute myeloid leukemia. However, development drug resistance severe adverse effects SMO pose major challenges that require alternative treatment strategies HH/GLI TIC...