A5062195455- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Asthma and respiratory diseases
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Allergic Rhinitis and Sensitization
- Pediatric Hepatobiliary Diseases and Treatments
- Cancer, Hypoxia, and Metabolism
- Lipid metabolism and biosynthesis
- Liver Diseases and Immunity
- Sphingolipid Metabolism and Signaling
- Immune cells in cancer
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Dietary Effects on Health
- Toxin Mechanisms and Immunotoxins
- Gallbladder and Bile Duct Disorders
- Psoriasis: Treatment and Pathogenesis
- Drug Transport and Resistance Mechanisms
- Free Radicals and Antioxidants
- Nutritional Studies and Diet
- Genomics and Chromatin Dynamics
- Neurological Disease Mechanisms and Treatments
- Tryptophan and brain disorders
Paracelsus Medical University
2018-2025
Innsbruck Medical University
2023-2024
Universität Innsbruck
2023-2024
Colorectal cancer (CRC) is a major public health burden and one of the leading causes cancer-related deaths worldwide. Screening programs facilitate early diagnosis can help to reduce poor outcomes. Serum metabolomics extract vital molecular information that may increase sensitivity specificity colonoscopy in combination with histopathological examination. The present study identifies serum metabolite patterns treatment-naïve patients, diagnosed either advanced adenoma (AA) or CRC...
BACKGROUND. Alterations in circulating metabolites have been described obese metabolic dysfunction-associated steatotic liver disease (MASLD), but data on lean MASLD are lacking. We investigated serum metabolites, including microbial bile acids (BAs) and short-chain fatty (SCFAs), their association with MASLD.
Aging is a key risk factor for many diseases, including cancer, and better understanding of its underlying molecular mechanisms may help to prevent, delay, or treat age-related pathologies. Epigenetic alterations such as DNA methylation (DNAme) changes are hallmark aging form the basis so-called epigenetic clocks, yet their functional relevance directionality in different organs during disease development often unclear. Here, we link cell-specific DNAme with three hallmarks cancer...
Abstract Originally Lipid droplets (LDs) were considered as being for lipid storage only. Increasing evidence, however, demonstrates that LDs fulfill a pleiotropy of additional functions. Among them is the modulation protein well homeostasis. Under unfavorable pro-oxidative conditions, proteins can form aggregates which may exceed overall proteolytic capacity proteasome. After stress termination adjust and support removal these aggregates. Additionally, interact with mitochondria,...
Neuroblastoma (NB) is a childhood cancer in which amplification of the MYCN gene most acknowledged marker poor prognosis. MYCN-amplified NB cells rely on both glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) for energy production. Previously, we demonstrated that ketogenic diet (KD) combined with metronomic cyclophosphamide (CP) delayed tumor growth xenografts. The anti-diabetic drug metformin (MET) also targets complex I OXPHOS system. Therefore, MET-induced disruptions...
As we reported previously, caloric restriction (CR) results in an increased concentration of bile acids (BA) the intestinal mucosa. We now investigated background this phenotype, trying to identify nutrition-related factors modulating BA levels. Male mice were submitted various types restrictive diets and levels expression associated measured. found that is liver CR mice, which corresponds reduced Shp gene elevated mRNA Cyp27a1, Bal, Ntcp, as well CYP7A1 protein expression. Correlation...
Anti-mitochondrial antibodies (AMA) are closely linked to primary biliary cholangitis (PBC). The prevalence of AMA in the general population is low, and positivity may precede PBC. We aimed determine natural history subjects with positive AMA.In total, 302 patients were tested AMA-positive over a ten-year period. Of these, immunoblotting confirmed specific 184 (29 male, 155 female, age 59.6 ± 14.1 years). These invited our liver outpatient clinic for clinical biochemical re-evaluation....
Abstract Microglia become progressively activated and seemingly dysfunctional with age, genetic studies have linked these cells to the pathogenesis of a growing number neurodegenerative diseases. Here we report striking buildup lipid droplets in microglia aging mouse human brains. These cells, which call droplet-accumulating (LAM), are defective phagocytosis, produce high levels reactive oxygen species, secrete pro-inflammatory cytokines. RNA sequencing analysis LAM revealed transcriptional...
Psoriasis is an inflammatory skin disease characterized by increased neo-vascularization, keratinocyte hyperproliferation, a pro-inflammatory cytokine milieu and immune cell infiltration. Diacerein anti-inflammatory drug, modulating functions, including expression production of cytokines, in different conditions. Therefore, we hypothesized that topical diacerein has beneficial effects on the course psoriasis. The current study aimed to evaluate effect imiquimod (IMQ)-induced psoriasis...
Abstract The chroman-like chalcone Xanthohumol C, originally found in hops, was demonstrated to be a potent neuroregenerative and neuroprotective natural product therefore constitutes strong candidate for further pharmaceutical research. bottleneck vivo experiments is the low water solubility of this chalcone. Consequently, we developed validated suitable formulation enabling administration. Cyclodextrins were used as water-soluble nontoxic complexing agents, complex C...
The leukotriene receptor antagonist Montelukast (MTK) is an approved medication for the treatment of asthma and allergic rhinitis. existing marketed tablet forms MTK exhibit inconsistent uptake bioavailability, which partially explains presence a significant proportion low- non-responders in population. Besides that, tablets are suboptimal formulations patients suffering from dysphagia, example, seen with neurodegenerative diseases such as Alzheimer's disease, disease increasing interest...
Quantification of the antiprogestin mifepristone and its active metabolite metapristone in plasma tissue female mice using HPLC-MS/MS.
Abstract The leukotriene receptor antagonist Montelukast (MTK) is an approved medication for the treatment of asthma and allergic rhinitis. existing marketed tablet forms MTK exhibit inconsistent uptake bioavailability, which partially explains presence a significant proportion low- non-responders in population. Besides that, tablets are suboptimal formulations patients suffering dysphagia, example seen COVID-19 or with neurodegenerative diseases such as Alzheimer’s Disease. increasing...
Tryptophan is an essential amino acid and plays important role in several metabolic processes relevant for the human health. As main pathway tryptophan along kynurenine axis involved inflammatory responses, changed metabolite levels can be used to monitor diseases such as ulcerative colitis. a progenitor of serotonin, altered have been related neurogenerative well depression or anxiety. While concentrations are commonly evaluated serum, non-invasive detection approach using saliva might...
Antimitochondrial antibody (AMA) positivity may precede the development of primary biliary cholangitis (PBC). It is unclear whether changes in serum bile acid (BA) composition already occur AMA-positive subjects without clinically overt PBC. We aimed to determine BA profile across spectrum AMA-positivity including known PBC (UDCA responders and non-responders), newly diagnosed PBC, AMA-positives AMA-negatives (negative AMA at second testing) healthy controls identify potential homeostasis...