A5020837171- Zebrafish Biomedical Research Applications
- Hippo pathway signaling and YAP/TAZ
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Neonatal Health and Biochemistry
- Biomarkers in Disease Mechanisms
- Biochemical and Molecular Research
- Ubiquitin and proteasome pathways
- Cellular Mechanics and Interactions
- Estrogen and related hormone effects
- Blood disorders and treatments
- Reproductive System and Pregnancy
- Cancer Mechanisms and Therapy
- Breast Cancer Treatment Studies
- Cancer Risks and Factors
- PARP inhibition in cancer therapy
- Caveolin-1 and cellular processes
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Infrared Thermography in Medicine
- Ectopic Pregnancy Diagnosis and Management
- Heme Oxygenase-1 and Carbon Monoxide
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- Science, Research, and Medicine
Karolinska Institutet
2015-2025
Salahaddin University-Erbil
2014-2025
Karolinska University Hospital
2024-2025
Weatherford College
2022
Normal human and murine fibroblasts can inhibit proliferation of tumor cells when cocultured in vitro. The inhibitory capacity varies depending on the donor site origin fibroblast. We showed previously that effective inhibition requires formation a morphologically intact fibroblast monolayer before seeding cells. Here we show is extended to motility dissect factors responsible for these functions. find due two different sets molecules: (i) extracellular matrix (ECM) other surface proteins...
Purpose: Cancer metastasis can occur at the early stage of tumor development when a primary is microscopic size. In particular, interaction malignant cells with other cell types including cancer-associated fibroblasts (CAF) in promoting remains largely unknown. Here, we investigated role CAFs facilitating initial events cancer tumors were sizes.Experimental Design: Multicolor-coded and coimplanted into transparent zebrafish body single-cell level was monitored living animals. Healthy...
Fibroblasts are a main player in the tumor-inhibitory microenvironment. Upon tumor initiation and progression, fibroblasts can lose their capacity promote growth. The molecular mechanisms that underlie this switch have not been defined completely. Previously, we identified four proteins overexpressed cancer-associated linked to Rho GTPase signaling. Here, show knocking out Ras homolog family member A (RhoA) gene normal decreased capacity, as judged by neighbor suppression vitro accompanied...
Abstract Prokineticin 1 (PROK1), a hypoxia‐regulated angiogenic factor, has emerged as crucial regulator of embryo implantation and placentation. Dysregulation PROK1 been linked to recurrent pregnancy loss, pre‐eclampsia, foetal growth restriction preterm birth. These complications are common in women with obesity polycystic ovary syndrome, i.e. conditions associated insulin resistance compensatory hyperinsulinaemia. We investigated the effect on expression during vitro decidualization....
There is growing evidence that emerging malignancies in solid tissues might be kept under control by physical intercellular contacts with normal fibroblasts.Here we characterize transcriptional landscapes of fibroblasts confronted cancer cells. We studied four pairs vitro and ex vivo fibroblast lines which, within each pair, differed their capacity to inhibit The natural process was modeled confronting the PC-3 Fibroblast transcriptomes were recorded Affymetrix microarrays then investigated...
Progesterone receptor antagonism is gaining attention due to progesterone's recognized role as a major mitogen in breast tissue. Limited but promising data suggest the potential efficacy of antiprogestins cancer prevention. The present study presents secondary outcomes from randomized controlled trial and examines changes mRNA expression following mifepristone treatment healthy premenopausal women. We analyzed 32 paired biopsies 16 women at baseline after two months treatment. In total, 27...
Abstract High-grade serous ovarian cancer, the most common and aggressive form of generally metastasises to visceral adipose tissues. In these tissues, extracellular matrix through which cancer cells adhere migrate is confined by presence preponderance adipocytes. How in this unique environment not known, yet critical understanding metastatic progression. To study processes, we develop biomimetic organo-hydrogels that recreate structural mechanical properties human We show present invasive...
Highly specific and potent inhibitors of dihydroorotate dehydrogenase (DHODH), an essential enzyme the de novo pyrimidine ribonucleotide synthesis pathway, are in clinical trials for autoimmune diseases, viral infections cancer. However, because DHODH (DHODHi) immunosuppressants they may reduce anticancer activity immune system. Therefore, there be a need to improve therapeutic index DHODHi cancer patients. The aim this study was find strategies protect activated T cells from identify types...
Retinoblastoma is an eye cancer that commonly affects young children. Despite significant advances, current treatments cause side effects even when administered locally, and patients may still have to undergo enucleation. This particularly disheartening in cases of bilateral retinoblastoma. Hence, there urgent need for novel therapeutic strategies. Inhibitors the enzyme dihydroorotate dehydrogenase (DHODH), which involved
Abstract Progesterone receptor antagonism is gaining attention due to progesterone’s recognized role as a major mitogen in breast tissue. Limited but promising data suggest the potential efficacy of antiprogestins cancer prevention. The present study presents secondary outcomes from randomized controlled trial and examine changes mRNA expression following mifepristone treatment healthy women. We analyzed 32 paired biopsies 16 premenopausal women at baseline after two months treatment. In...
Background: Tissue-specificity for fimbrial fallopian tube ovarian carcinogenesis remains largely unknown in BRCA1 mutation carriers. We aimed to assess the cell autonomous and cell-nonautonomous implications of a germline context cancer immunosurveillance CD3− CD56+ natural killer (NK) cells. Methods: Premenopausal carriers versus age-matched non-carriers were compared. Daily urinary 5β-pregnanediol levels used determine progesterone metabolomics across an cycle. Using peripherally acquired...
<p>Growth factor-stimulated fibroblasts promote NSCLC metastasis</p>
<p>Supplementary Figure Legends</p>
<p>Mouse CAFs promote CRC metastasis</p>
<p>Gene expression in PDGF-BB stimulated fibroblasts</p>
<p>Video - Dissemination of CAF-cancer cell complex</p>
<p>Human CRC tumor fibrosis and isolation of CAFs</p>