A5083389594- Ion Channels and Receptors
- Ion channel regulation and function
- Neurological Complications and Syndromes
- Pancreatic function and diabetes
- Cardiac electrophysiology and arrhythmias
- Adipokines, Inflammation, and Metabolic Diseases
- Endoplasmic Reticulum Stress and Disease
- Neuroblastoma Research and Treatments
- RNA regulation and disease
- Neuroinflammation and Neurodegeneration Mechanisms
- Histiocytic Disorders and Treatments
- Moyamoya disease diagnosis and treatment
- Genital Health and Disease
- Calpain Protease Function and Regulation
- Neuroscience of respiration and sleep
- Childhood Cancer Survivors' Quality of Life
- Adipose Tissue and Metabolism
- Adenosine and Purinergic Signaling
- High Altitude and Hypoxia
- Phytochemicals and Antioxidant Activities
- ATP Synthase and ATPases Research
- Obstructive Sleep Apnea Research
- Signaling Pathways in Disease
- Cancer-related gene regulation
- Growth Hormone and Insulin-like Growth Factors
Yonsei University
2007-2021
Chung-Ang University
2004-2020
Samsung Medical Center
2015
Seoul National University Children's Hospital
2015
Sunchon National University
2015
Sungkyunkwan University
2015
Anoctamin (ANO)/transmembrane member 16 (TMEM16) proteins mediate diverse physiological and pathophysiological functions including cancer cell proliferation. The present study aimed to identify the role of ANOs in pancreatic cancer.In an initial screen ANOs, ANO9/TMEM16J was overexpressed cells, its pathogenesis evaluated using integrated vitro vivo approach. To determine clinical relevance experimental findings, prognostic value ANO9 patients with cancer.The mRNA protein levels were...
Objective–– Moyamoya disease (MMD) is a common cause of childhood stroke, in which the abnormal function endothelial colony–forming cell (ECFC) plays key role pathogenesis disease. This study was designed to identify genes involved MMD using gene expression profiling and understand defective ECFCs. Approach Results–– We compared profiles ECFCs isolated from patients with normal controls. Among differentially expressed genes, we selected most downregulated expression, retinaldehyde...
STIM1 is the only currently known intracellular calcium sensor that functions as influx regulator controlling immune cell activation. function in signalling has been studied extensively; however, its role microglia, innate cells brain, not fully understood. Here, we report STIM1-/- murine microglia lost store-operated and displayed aberrant immunological functions. Microglial regulated by chronic global [Ca2+]i changes were reduced significantly, including cytokine releases opsonin-dependent...
Background: Genetic variations in calpain-10 and adiponectin gene are known to influence insulin secretion resistance type 2 diabetes mellitus.Recently, several single nucleotide polymorphisms (SNPs) have been reported be associated with various metabolic derangements.We investigated the associations between specific Korean patients.Methods: Overall, 249 patients 131 non-diabetic control subjects were enrolled this study.All genotyped for SNP-43 -63 of G276T T45G frequencies gene.The...
No studies have investigated sequential changes in the heart on magnetic resonance imaging (MRI), along with observation of functional lung phenotypes and genetics, over duration chronic intermittent hypoxia (CIH). We chronological after CIH using a mouse model to provide new insights into pathophysiology sleep apnea-induced cardiovascular disease. C57BL/6J adult male mice were randomized 4 or 8 weeks CIH. Cardiac cine-MRI images analyzed assess parameters right ventricle (RV)....
Jung Woo Han, Woon Heo, Donghyuk Lee, Choeun Kang, Hye-Yeon Kim, Ikhyun Jun, Insuk So, Hyuk Hur, Min Goo Minkyu Jung, and Joo Young Kim. Mol. Cells 2021;44:223-32. https://doi.org/10.14348/molcells.2021.2031
Abstract Background Pazopanib, a multitargeted tyrosine kinase inhibitor, is recommended as the standard treatment for refractory soft tissue sarcoma (STS). However, there are comparatively few molecular determinants predicting pazopanib efficacy. Based on correlative studies regarding predictive impact of PD-L1, we investigated clinical relevance PD-L1 expression and evaluated its value Methods Tumour tissues from patients with advanced STS who went to receive were assessed expression....
Abstract Purpose: The purpose of the current study was to explore physical activity (PA) and exercise participation, preferences, barriers PA in childhood cancer survivors. Methods: We surveyed 120 survivors adolescence from pediatric oncology center South Korea between March August 2017. modified Exercise & Quality Life questionnaire, Youth Risk Behavior Web-based Survey, Godin Leisure-Time Questionnaire were used assess levels, barriers. Results: Among participants (72 boys, 48 girls)...