A5005595930- Geology and Paleoclimatology Research
- Cryospheric studies and observations
- Methane Hydrates and Related Phenomena
- Landslides and related hazards
- Traditional Chinese Medicine Analysis
- Climate change and permafrost
- Pharmacological Effects of Natural Compounds
- Flavonoids in Medical Research
- Geological and Geochemical Analysis
- Winter Sports Injuries and Performance
- Ginseng Biological Effects and Applications
- Marine and environmental studies
- Polar Research and Ecology
- Hydrocarbon exploration and reservoir analysis
- Geological Studies and Exploration
- Microbial Community Ecology and Physiology
- Paleontology and Stratigraphy of Fossils
- Geological formations and processes
- Phytochemistry and Biological Activities
- Geochemistry and Geologic Mapping
- Atmospheric and Environmental Gas Dynamics
- Drug Transport and Resistance Mechanisms
- Atmospheric Ozone and Climate
- ATP Synthase and ATPases Research
- Bioactive natural compounds
Alfred-Wegener-Institut Helmholtz-Zentrum für Polar- und Meeresforschung
2017-2025
Irvine University
2025
University of California, Irvine
2025
Jilin Jianzhu University
2024
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
First Affiliated Hospital of Henan University
2019-2023
Tianjin University of Traditional Chinese Medicine
2020-2022
Lanzhou University
2021
China University of Geosciences (Beijing)
2021
Shenmai injection (SMI), as a patented traditional Chinese medicine, is extracted from Panax ginseng and Ophiopogon japonicus. It commonly used in the treatment of cardiovascular disease control cardiac toxicity induced by doxorubicin (DOX) treatment. However, its anti-cardiotoxicity mechanism remains unknown. The purpose this study was to investigate underlying mitochondrial protective mechanisms SMI on DOX-induced myocardial injury. cardioprotective effect against damage evaluated C57BL/6...
ABSTRACT The evolution of Northern Hemisphere ice sheets through the last glacial cycle is simulated with index method by using climate forcing from one General Circulation Model, COSMOS. By comparing results to geological reconstructions, we first show that modelled capable capturing main features ice-sheet evolution. However, large deviations exist, likely due absence nonlinear interactions between sheet and other components. model uncertainties are examined output nine models Paleoclimate...
Using transient climate forcing based on simulations from the Alfred Wegener Institute Earth System Model (AWI-ESM), we simulate evolution of Greenland Ice Sheet (GrIS) last interglacial (125 ka, kiloyear before present) to 2100 AD with Parallel (PISM). The impact paleoclimate, especially Holocene climate, present and future GrIS is explored. Our past show close agreement reconstructions respect recent timing peaks in ice volume Greenland. maximum minimum at around 18–17 ka 6–5 lag...
One of Earth’s most fundamental climate shifts, the greenhouse-icehouse transition 34 million years ago, initiated Antarctic ice sheet buildup, influencing global until today. However, extent during Early Oligocene Glacial Maximum (~33.7 to 33.2 ago) that immediately followed this transition—a critical knowledge gap for assessing feedbacks between permanently glaciated areas and early Cenozoic reorganization—is uncertain. In work, we present shallow-marine drilling data constraining earliest...
Abstract Freshwater perturbations are often thought to be associated with abrupt climate changes during the last deglaciation, while many uncertainties remain regarding exact timing, pathway, mechanism, and influence of meltwater release. Here, we present very well-dated high-resolution records from eastern Labrador Sea representing 19.000 years, which demonstrate in sea surface characteristics. Four millennial-scale events have been identified between 14.000 8.200 years based on independent...
Background Increasing evidence suggests that gut dysbiosis can directly or indirectly affect the immune system through brain-gut axis and play a role in occurrence development of Multiple sclerosis (MS). Oxymatrine (OMAT) has been shown to ameliorate symptoms MS classical experimental autoimmune encephalomyelitis (EAE) model MS, but whether its therapeutic is correction dysbiosis, unclear. Methods The effects OMAT on intestinal flora short-chain fatty acids EAE mice were evaluated by 16S...
The Eocene-Oligocene Transition (EOT) (~34.4–33.7 Ma) is not only known for its drastic shift from greenhouse to icehouse climate, but also a dynamic ocean gateway configuration. Southern Ocean gateways are expected open during this period, while the Arctic likely remains largely isolated, resulting in distinct circulation patterns.Using AWI-Earth System Model (AWI-ESM) coupled Parallel Ice Sheet (PISM), we explore dynamics under an straight configuration markedly different...
Abstract Rapid warming is likely increasing primary production and wildfire occurrence in the Arctic. Projected changes carbonaceous aerosols during summer will impact atmospheric chemistry climate, but our understanding of these processes limited by sparse observations. Here, we characterize aerosol Alaska, USA: Toolik Field Station Interior Atmospheric Radiation Measurement facility at Utqiaġvik on Arctic coast, summers 2022 2023. We estimated PM 2.5 10 concentrations using laser light...
Shenmai injection (SMI) has been used in the treatment of cardiovascular disease (CVD), such as heart failure, myocardial ischemia and coronary disease. It found to have efficacy on doxorubicin (DOX)-induced cardiomyopathy. The aims this study were explore underlying molecular mechanisms SMI CVD by using network pharmacology its protective effect DOX-induced cardiotoxicity vitro vivo experiment based prediction.Network method was reveal relationship between ingredient-target-disease...
Previous modelling efforts have investigated climate responses to different Milankovitch forcing during Marine Isotope Stage (MIS) 13. During this time the has been highly variable at atmospheric CO2 concentrations of ~240 ppm. As yet, ice sheet-climate feedbacks were missing in previous studies. Therefore we use state-of-the-art coupled climate-ice sheet model, AWI-ESM-1.2, investigate MIS-13 and corresponding Northern Hemisphere (NHIS) evolution by performing simulations under three...
Abstract There has been extensive research into the nonlinear responses of Earth system to astronomical forcing during last glacial cycle. However, speed and spatial geometry ice sheet expansion its largest extent at Last Glacial Maximum 21 thousand years ago remains uncertain. Here we use an model with interactive sheets show that distinct initial North American (Laurentide) 38 converge towards a configuration consistent due feedbacks between atmospheric circulation geometry. Notably,...
Abstract. The ice–substrate interface is an important boundary condition for ice sheet modelling. substrate affects the by allowing sliding through sediment deformation and accommodating storage drainage of subglacial water. We present three datasets on a 1 : 5 000 scale with different geological parameters region that was covered sheets in North America, including Greenland Iceland. first dataset includes distribution surficial sediments, which separated into continuous, discontinuous...
Abstract Evidence from proxy records indicates that millennial‐scale abrupt climate shifts, called Dansgaard‐Oeschger events, happened during past glacial cycles. Various studies have been conducted to uncover the physical mechanism behind them, based on assumption mean state determines variability. However, our study shows events can regulate of Northern Hemisphere ice sheets. Sensitivity experiments show simulated is influenced by amplitude climatic noise. The most likely cause this...
Objective: To compare the pharmacokinetic differences of main components Naoxintong capsule (NXTC) in normal and acute blood stasis rats. Materials Methods: Rats were subcutaneously injected with adrenaline hydrochloride twice; during two subcutaneous injections, rats placed ice water for 4 min to reproduce model rat stasis. The administrated a 5.04 g/kg dose NXTC suspension. Then, samples collected from posterior retinal venous plexus at different time points. Plasma concentrations four...
Abstract Spatially variable basal conditions are thought to govern how ice sheets behave at glacial time scales (>1000 years) and responsible for changes in dynamics between the core peripheral regions of Laurentide Fennoscandian sheets. Basal motion is accomplished via deformation unconsolidated sediments, or sliding over an undeformable bed. We present sheet module Parallel Ice Sheet Model (PISM) that takes into account sediment cover incorporates surface meltwater. This model routes...