Calvin Wai-Loon Ho

ORCID: 0000-0002-8328-1308
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About
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Research Areas
  • Ethics in Clinical Research
  • Biomedical Ethics and Regulation
  • Ethics in medical practice
  • Artificial Intelligence in Healthcare and Education
  • Law, AI, and Intellectual Property
  • Healthcare cost, quality, practices
  • Ethics and Social Impacts of AI
  • Intellectual Property and Patents
  • Ethics and Legal Issues in Pediatric Healthcare
  • CRISPR and Genetic Engineering
  • Pharmaceutical Economics and Policy
  • Viral Infections and Outbreaks Research
  • Health Systems, Economic Evaluations, Quality of Life
  • Global Security and Public Health
  • Medical Malpractice and Liability Issues
  • Legal Education and Practice Innovations
  • Patient Dignity and Privacy
  • Pluripotent Stem Cells Research
  • Global Health Care Issues
  • Healthcare Systems and Reforms
  • Public Health Policies and Education
  • Palliative Care and End-of-Life Issues
  • Race, Genetics, and Society
  • Genetic Associations and Epidemiology
  • Zoonotic diseases and public health

University of Hong Kong
2010-2025

Monash University
2024-2025

University of Cambridge
2010-2025

PHG Foundation
2024-2025

Australian Regenerative Medicine Institute
2024

Denali Therapeutics (United States)
2022

Chinese University of Hong Kong
2010-2021

University of Leicester
2021

National University of Singapore
2012-2020

University of Oxford
2013-2014

Heidi L. Rehm Angela Page Lindsay Smith Jeremy Adams Gil Alterovitz and 95 more Lawrence Babb Maxmillian P. Barkley Michael Baudis Michael J. S. Beauvais Tim Beck J. Beckmann Sergi Beltrán David L. Bernick Alexander Bernier James Bonfield Tiffany Boughtwood Guillaume Bourque Sarion R. Bowers Anthony J. Brookes Michael Brudno Matthew Brush David Bujold Tony Burdett Orion J. Buske Moran N. Cabili Daniel Cameron Robert J. Carroll Esmeralda Casas-Silva Debyani Chakravarty Bimal P. Chaudhari Shu Hui Chen J. Michael Cherry Justina Chung Melissa Cline Hayley Clissold Robert Cook‐Deegan Mélanie Courtot Fiona Cunningham Miro Cupak Robert M. Davies Danielle Denisko Megan Doerr Lena Dolman Edward S. Dove Lewis Jonathan Dursi Stephanie O. M. Dyke James A. Eddy Karen Eilbeck Kyle Ellrott Susan Fairley Khalid A. Fakhro Helen V. Firth Michael S. Fitzsimons Marc Fiume Paul Flicek Ian Fore Mallory Freeberg Robert R. Freimuth Lauren A. Fromont Jonathan Fuerth Clara Gaff Weiniu Gan Elena M. Ghanaim David Glazer Robert C. Green Malachi Griffith Obi L. Griffith Robert L. Grossman Tudor Groza Jaime M. Guidry Auvil Roderic Guigó Dipayan Gupta Melissa Haendel Ada Hamosh David Hansen Reece K. Hart Dean M. Hartley David Haussler Rachele Hendricks‐Sturrup Calvin Wai-Loon Ho Ashley E. Hobb Michael M. Hoffman Oliver Hofmann Petr Holub Jacob Shujui Hsu Jean‐Pierre Hubaux Sarah Hunt Ammar Husami Julius O.B. Jacobsen Saumya S. Jamuar Elizabeth Janes Francis Jeanson Aina Jené Amber L. Johns Yann Joly Steven J.M. Jones Alexander Kanitz Yoshihiro Kato Thomas Keane Kristina Kekesi-Lafrance

The Global Alliance for Genomics and Health (GA4GH) aims to accelerate biomedical advances by enabling the responsible sharing of clinical genomic data through both harmonized aggregation federated approaches. decreasing cost sequencing (along with other genome-wide molecular assays) increasing evidence its utility will soon drive generation sequence from tens millions humans, levels diversity. In this perspective, we present GA4GH strategies addressing major challenges revolution. We...

10.1016/j.xgen.2021.100029 article EN cc-by-nc-nd Cell Genomics 2021-11-01

Abstract Artificial intelligence (AI) enables a medical device to optimize its performance through machine learning (ML), including the ability learn from past experiences. In healthcare, ML is currently applied within controlled settings in devices diagnose conditions like diabetic retinopathy without clinician input, for instance. order allow AI-based (AIMDs) adapt actively data environment ML, current risk-based regulatory approaches are inadequate facilitating this technological...

10.1093/jlb/lsad026 article EN cc-by Journal of Law and the Biosciences 2023-07-01

Technological advances in big data (large amounts of highly varied from many different sources that may be processed rapidly), sciences and artificial intelligence can improve health-system functions promote personalized care public good. However, these technologies will not replace the fundamental components health system, such as ethical leadership governance, or avoid need for a robust regulatory environment. In this paper, we discuss what environment might look like analytics insurance,...

10.2471/blt.19.234732 article EN cc-by Bulletin of the World Health Organization 2020-02-25

are trying to find ways ease some restrictions while also minimizing public health risk.2][13] In doing so, governments recognize that they may need reverse course and impose more restrictive measures again, if data show increasing spread of SARS-CoV-2.

10.2471/blt.20.280701 article EN cc-by Bulletin of the World Health Organization 2020-12-01

Abstract Research, innovation, and progress in the life sciences are increasingly contingent on access to large quantities of data. This is one key premises behind “open science” movement global calls for fostering sharing personal data, datasets, research results. paper reports outcomes discussions by panel “Open science, data solidarity: who benefits?” held at 2021 Biennial conference International Society History, Philosophy, Social Studies Biology (ISHPSSB), hosted Cold Spring Harbor...

10.1007/s40656-021-00468-6 article EN cc-by History & Philosophy of the Life Sciences 2021-11-11

The operationalization of One Health (OH) through digitalization is a means to deploy digital technologies (including Artificial Intelligence (AI), big data and related technologies) better capacitate us deal with growing climate exigency threats human, animal plant health. With reference the concept Digital (ODH), this paper considers how capabilities can help overcome ‘operational brakes’ in OH new deeper insights, predictions, more targeted or precise preventive strategies public health...

10.3389/fpubh.2022.768977 article EN cc-by Frontiers in Public Health 2022-05-03

Background During health emergencies, effective infodemic management has become a paramount challenge. A new era marked by rapidly changing information ecosystem, combined with the widespread dissemination of misinformation and disinformation, magnified complexity issue. For measures to be effective, acceptable, trustworthy, robust framework ethical considerations is needed. Objective This systematic scoping review aims identify analyze procedural principles relevant management, ultimately...

10.2196/56307 article EN cc-by JMIR Infodemiology 2024-08-29

ABSTRACT The World Congress of Bioethics held in Qatar 2024 (WCB 2024) sparked controversy around the role religion bioethics, highlighting need for critical discussions. During congress, there was a strong push incorporating religious values into bioethical discourse, raising questions about validity and implications such an approach. This paper examines influence thought on discussions, ongoing debate over perspectives this field. Here, we explore Jecker colleagues’ pluriversal framework,...

10.1111/bioe.13419 article EN cc-by Bioethics 2025-04-28

This article refers to:Patenting Foundational Technologies: Lessons From CRISPR and Other Core Biotechnologies

10.1080/15265161.2018.1531173 article EN The American Journal of Bioethics 2018-12-02

Abstract With focus on the development and use of artificial intelligence (AI) systems in digital health context, we consider following questions: How does European Union (EU) seek to facilitate uptake trustworthy AI through Act? What trustworthiness trust mean Act, how are they linked some ongoing discussions these terms bioethics, law, philosophy? normative components trustworthiness? And do requirements Act relate components? We first explain EU seeks create an epistemic environment...

10.1007/s41649-024-00304-6 article EN cc-by Asian Bioethics Review 2024-06-24
Madeline L. Page Elizabeth Vance Matthew Cloward Ed Ringger Louisa Dayton and 95 more Mark Ebbert Myron Weiner Paul Aisen Rebecca A. Petersen Clifford R. Jack William J. Jagust John Q. Trojanowki Arthur W. Toga Laurel Beckett R. C. Green Andrew J. Saykin Julia Morris Richard J. Perrin Les Shaw Zaven S. Khachaturian María C. Carrillo William Z. Potter Lisa L. Barnes Manon Bernard Héctor M. González Calvin Wai-Loon Ho John Hsiao Jacqueline M Jackson Eliezer Masliah D. Masterman Ozioma C. Okonkwo Richard J. Perrin Louise Ryan Jonathan I. Silverberg Adam Fleisher D. T. Sacrey Juliet Fockler Costanza Conti Dallas P. Veitch John Neuhaus Chongyao Jin Rachel L. Nosheny Miriam T. Ashford Derek Flenniken Adrieene Kormos T. Monine Michael S. Rafii Rajiv Raman Gustavo Jiménez Michael Donohue Devon Gessert Joel Salazar Christina Zimmerman Yuliana Cabrera Sarah Walter Gabrielle Miller G. Coker T. Clanton Lindsey Hergesheimer Samuel Pattillo Smith Oluwatoyin Adegoke P. Mahboubi Scott D. Moore J. Pizzola E. Shaffer B. Sloan Danielle Harvey Arivn Forghanian-Arani Bret Borowski Chad Ward Charlotte Schwarz David T. Jones J Günter Kejal Kantarci Matthew L. Senjem Prashanthi Vemuri Ronald E. Reid Nick C. Fox Ian B. Malone Pamela J. Thompson Sophia I. Thomopoulos Talia M. Nir Neda Jahanshad Charles DeCarli Alex Knaack Evan Fletcher D. Tosun-Turgut S. R. Chen Mi Kyung Choe Karen Crawford Paul A. Yushkevich Sayantan Das Robert A. Koeppe Eric M. Reiman K. Chen Chester A. Mathis Susan Landau N. J. Cairns Erin Householder Erin Franklin

Abstract The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present centralized score calculator currently containing over 250,000 genetic variant associations from NHGRI-EBI GWAS Catalog for users easily sample-specific with comparable results other available tools. Polygenic are calculated either online through Risk Score Knowledge Base (PRSKB;...

10.1038/s42003-022-03795-x article EN cc-by Communications Biology 2022-09-02
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