A5013090450- RNA and protein synthesis mechanisms
- Enzyme Structure and Function
- DNA and Nucleic Acid Chemistry
- Advanced biosensing and bioanalysis techniques
- Protein Structure and Dynamics
- RNA Interference and Gene Delivery
- Bacterial Genetics and Biotechnology
- Genetics, Bioinformatics, and Biomedical Research
- Mass Spectrometry Techniques and Applications
- Gold and Silver Nanoparticles Synthesis and Applications
- Cardiac, Anesthesia and Surgical Outcomes
- Grief, Bereavement, and Mental Health
- Nanocluster Synthesis and Applications
- Synthesis and bioactivity of alkaloids
- Cholinesterase and Neurodegenerative Diseases
- Kidney Stones and Urolithiasis Treatments
- Ectopic Pregnancy Diagnosis and Management
- Curcumin's Biomedical Applications
- Maternal and fetal healthcare
- RNA modifications and cancer
- Anesthesia and Sedative Agents
- Abdominal Surgery and Complications
- Intensive Care Unit Cognitive Disorders
- Ultrasound in Clinical Applications
- Building materials and conservation
Postnova Analytics (Germany)
2025
University Hospital Bonn
2020-2021
University of Naples Federico II
2013-2020
Naples Anesthesia & Physician Associates
2019-2020
Cornell University
2019-2020
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2015-2016
Postoperative delirium (POD) following surgery is a prevalent and distressing condition associated with adverse patient outcomes an increased healthcare burden. To assess the effectiveness of Safe Brain Initiative care bundle (SBI-CB) in reducing POD postanesthesia unit (PACU). A multicenter, quality-improvement initiative retrospective analysis collected data. The study was conducted operating rooms units (PACUs) four hospitals across Denmark Turkey. convenience sample patients were aged...
Abstract Nucleic acids can fold into G-quadruplex (G4) structures that fine-tune biological processes. Proteins are required to recognize G4 and coordinate their function. Here we identify Zuo1 as a novel G4-binding protein in vitro vivo. In vivo the absence of fewer form, cell growth slows cells become UV sensitive. Subsequent experiments reveal these cellular changes due reduced levels structures. function at results recruitment nucleotide excision repair (NER) factors, which has positive...
Polarized ultraviolet resonance Raman scattering at 266 nm was used to investigate the interaction of BRACO-19 and Pyridostatin with G-quadruplexes having different structural conformations.
A combination of mass spectrometry, Raman microspectroscopy, circular dichroism and X-ray crystallography has been used to obtain detailed information on the reaction an iridium-based CO-releasing molecule (Ir-CORM), Cs2IrCl5CO, with a model protein, bovine pancreatic ribonuclease. The results show that Ir-compound fragments bind N-terminal amine close histidine methionine side chains, CO ligand is retained for long time. data provide helpful identifying protein targets Ir-CORMs studying...
The G-quadruplex-forming telomeric sequence (TTAGGG)<sub>4</sub>TT was investigated by polarized Ultraviolet Resonance Raman Scattering (UVRR) at 266 nm.
Biofilms are a multicellular way of life, where bacterial cells close together and embedded in hydrated macromolecular matrix which offers number advantages to the cells. Extracellular polysaccharides play an important role setup maintenance. A water-insoluble polysaccharide was isolated purified from biofilm produced by Burkholderia cenocepacia strain H111, cystic fibrosis pathogen. Its composition glycosidic linkages were determined using Gas-Liquid Chromatography-Mass Spectrometry...
Harmine belongs to a group of β-carboline alkaloids endowed with antitumor properties. and its derivatives are thought bind DNA interfere topoisomerase activities. We investigated the base-dependent binding harmine, three synthetic anticancer-active genomic from calf thymus two 20-mer double helices, poly(dG-dC)·poly(dG-dC) poly(dA-dT)·poly(dA-dT), by means UV-Vis circular dichroism (CD) spectroscopies. The data show that stabilising properties base pair-dependent. These results could be...
Hydroxylamine-<italic>O</italic>-sulfonamide has been investigated as CA inhibitor by means of kinetic and structural studies clarifying its mechanism action.
The Cytotoxic Necrotizing Factor 1 (CNF1) is a bacterial toxin secreted by certain Escherichia coli strains causing severe pathologies, making it protein of pivotal interest in toxicology. In parallel, the CNF1 capability to influence important neuronal processes, like arborization, astrocytic support, and efficient ATP production, has been efficiently used treatment neurological diseases, promising candidate for therapy. Nonetheless, there are still some unsolved issues about mechanism...
The RuIII-based prodrug AziRu efficiently binds to proteins, but the mechanism of its release is still disputed. Herein, in order test hypothesis a reduction-mediated Ru from Raman-assisted crystallographic study on binding model protein (hen egg white lysozyme), two different oxidation states, RuII and RuIII, was carried out. Our results indicate reduction, upon reduction dependent reducing agent. To better understand this process, pH-dependent, spectroelectrochemical surface-enhanced Raman...
Background Deep sternal wound infections (DSWI) are severe complications in up to 1.36% of coronary artery bypass grafting (CABG) procedures the United Kingdom. Each event adds between £4,000 and £11,000 healthcare costs, owing primarily prolonged hospitalisations. ECG devices have been shown convey infection throughout perioperative CABG. On other hand, single-patient (spECG) can effectively reduce incidence surgical site (SSI), including DSWI, but no assessment spECG impact NHS cardiac...
Abstract The knowledge on the material production from archaeological sites contains valuable information technological advances and commercial routes of a civilization. Archaeologists can face some ambiguities in assessment productive function furnaces emerging excavation when markers are not available due to poor conservation state. A protocol discriminate among lime ceramics is major aim this work. Indeed, herein, we address possibility assist archaeologists by vibrational...