A5066659467- Synthesis and pharmacology of benzodiazepine derivatives
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Synthesis and biological activity
- Cancer Treatment and Pharmacology
- Inflammatory mediators and NSAID effects
- Crystallization and Solubility Studies
- Synthesis and Biological Evaluation
- X-ray Diffraction in Crystallography
- Synthesis and bioactivity of alkaloids
- Advanced biosensing and bioanalysis techniques
- Asthma and respiratory diseases
- DNA and Nucleic Acid Chemistry
- Coordination Chemistry and Organometallics
- RNA and protein synthesis mechanisms
- Phytochemicals and Antioxidant Activities
- Chemical Synthesis and Analysis
- Estrogen and related hormone effects
- Natural product bioactivities and synthesis
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Reactions
- Multicomponent Synthesis of Heterocycles
- Advanced Drug Delivery Systems
University of Sannio
2016-2024
Istituti Clinici Scientifici Maugeri
2022-2023
University of Campania "Luigi Vanvitelli"
2014-2021
Institute of Food Science
2018-2019
National Research Council
2018-2019
Centre de Médecine Préventive
2019
University of Naples Federico II
2014-2017
University of Salerno
2007-2016
Johannes Kepler University of Linz
2016
Naples Anesthesia & Physician Associates
2016
Hyaluronan (HA) is frequently incorporated in eye drops to extend the pre-corneal residence time, due its viscosifying and mucoadhesive properties. Hydrodynamic rheological evaluations of commercial products are first accomplished revealing molecular weights varying from about 360 1200kDa viscosity values range 3.7-24.2mPa s. The latter suggest that most could be optimized towards resistance drainage ocular surface. Then, a study aiming maximize mucoadhesiveness HA-based preparations...
New bifunctional chiral ammonium salts were investigated in an asymmetric cascade synthesis of a key building block for variety biologically relevant isoindolinones. With this compound hand, the development further transformations allowed diverse derivatives high pharmaceutical value, such as Belliotti ( S )-PD172938 and arylated analogues with hypnotic sedative activity, obtained good overall total yield (50%) enantiomeric purity (95% ee). The synthetic routes developed herein are...
Diabetes mellitus, one of the most common endocrine-metabolic disorders, has caused significant morbidity and mortality worldwide. To avoid sugar digestion postprandial hyperglycemia, it is necessary to inhibit α-glucosidase, a digestive enzyme with an important role in carbohydrate digestion. The criteria for selection alkaloids are based on their vitro vivo activities glucose modulation. current study assessed bonding potential isolated targeted protein. For this purpose, 3D structure...
Abstract Treatment for tumors depends on host immune system. The antitumor and immunoregulatory activities of Ulva lactuca polysaccharide (ULP) were evaluated in H22 tumor‐bearing mice cyclophosphamide‐induced immunosuppressed mice, respectively. structural properties ULP identified through multi‐angle laser light scattering, high‐performance liquid chromatography, Fourier‐transformed infrared, nuclear magnetic resonance. It was composed α‐D‐Man p ‐(1→, →2,4)‐β‐L‐Rha β‐D‐Glc A‐(1→, β‐Gal...
Quercetin is a hydrophobic molecule with short blood circulation times and instability. The development of nano-delivery system formulation quercetin may increase its bioavailability, resulting in greater tumor suppressing effects. Triblock ABA type polycaprolactone-polyethylenglycol- polycaprolactone (PCL-PEG-PCL) copolymers have been synthetized using ring-opening polymerization caprolactone from PEG diol. were characterized by nuclear magnetic resonance (NMR), diffusion-ordered NMR...
Abstract An efficient potassium carbonate‐catalyzed synthesis of 3‐substituted isoindolinones through tandem aldol/cyclization reactions active methylene compounds with 2‐cyanobenzaldehyde is described. The utility the obtained has been demonstrated an exploration chemical space by employing a series interesting methodologies that led to diverse, highly functionalized compounds. Among them, surprisingly straightforward potassiumcarbonate‐catalyzed double reaction tricyclic hemiaminal derivatives.