A5022933352- Pharmacogenetics and Drug Metabolism
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
- Neuroendocrine regulation and behavior
- Statistical Methods in Clinical Trials
- Stress Responses and Cortisol
- Computational Drug Discovery Methods
- Chemical Reactions and Isotopes
- Evolutionary Psychology and Human Behavior
- Bipolar Disorder and Treatment
- Hypothalamic control of reproductive hormones
- RNA modifications and cancer
- Pharmacological Effects and Toxicity Studies
- Diet and metabolism studies
- Neuroscience of respiration and sleep
- Pharmaceutical studies and practices
- Literary Theory and Cultural Hermeneutics
- Postcolonial and Cultural Literary Studies
- Prenatal Screening and Diagnostics
- Global Maritime and Colonial Histories
- Economic and Industrial Development
- Genomics and Rare Diseases
- Diverse Industrial Engineering Technologies
- Biosimilars and Bioanalytical Methods
- Eicosanoids and Hypertension Pharmacology
University of Alberta
2019-2022
University of Illinois Chicago
2002-2015
Ashland (United States)
2006
Abstract Background The Dlk1 and Gtl2 genes define a region of mouse chromosome 12 that is subject to genomic imprinting, the parental allele-specific expression gene. Although imprinted play important roles in growth development, mechanisms by which imprinting established maintained are poorly understood. Differentially methylated regions (DMRs), carry methylation on only one allele, involved control at many loci. - contains three known DMRs, DMR 3' , intergenic 15 kb upstream promoter....
Abstract Many antidepressants, atomoxetine, and several antipsychotics are metabolized by the cytochrome P450 enzymes CYP2D6 CYP2C19, guidelines for prescribers based on genetic variants exist. Although some laboratories offer such testing, there is no consensus regarding validated methodology clinical genotyping of CYP2C19 . The aim this paper was to cross-validate multiple technologies against each other, contribute feasibility implementation providing an enhanced range assay options,...
ABSTRACT Here, for the first time, expression of estrogen receptor beta (ERβ) is characterized in brains highly prosocial prairie vole ( Microtus ochrogaster ). ERβ immunoreactivity was compared weanlings (postnatal Day 21) and adult males females. The results indicate several major findings. First, unlike ERα, not sexually dimorphic. Second, pattern ERβ‐IR established at time weaning, as there were no age‐dependent effects on distribution. Finally, does appear to be widely distributed voles...
Abstract Background CYP2D6 and CYP2C19 are cytochrome P450 enzymes involved in the metabolism of many medications from multiple therapeutic classes. Associations between patterns variants (known as haplotypes) genes encoding them ( ) enzyme activities well described. The fact comprise 21% biomarkers drug labels. Despite this, genotyping is not common, partly attributable to its challenging nature having >100 haplotypes, including those with sequence an adjacent pseudogene, gene...
Abstract There are some data associating variants in the CYP2D6 and/or CYP2C19 genes with concentration-to-dose ratios, efficacy, and retention treatments. However, much of above arises from relatively small studies or large datasets limited genotyping methodologies. Our aim was to develop validate comprehensive accurate methodology for these two facilitate regenotyping hence generation more clinical associations. TaqMan copy number variant (CNV) assays were used identify samples a relevant...