A5043380117- Air Quality and Health Impacts
- Indoor Air Quality and Microbial Exposure
- Atmospheric chemistry and aerosols
- Air Quality Monitoring and Forecasting
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Occupational and environmental lung diseases
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- Mesenchymal stem cell research
- Cancer Cells and Metastasis
- Toxic Organic Pollutants Impact
Helmholtz Zentrum München
2021-2025
University of Rostock
2022-2025
Background: Secondary organic aerosols (SOAs) formed from anthropogenic or biogenic gaseous precursors in the atmosphere substantially contribute to ambient fine particulate matter [PM ≤2.5μm aerodynamic diameter (PM2.5)] burden, which has been associated with adverse human health effects. However, there is only limited evidence on their differential toxicological impact. Objectives: We aimed discriminate effects of generated by atmospheric aging combustion soot particles (SPs) (β-pinene)...
The health effects of exposure to secondary organic aerosols (SOAs) are still limited. Here, we investigated and compared the toxicities soot particles (SP) coated with β-pinene SOA (SOAβPin-SP) SP naphthalene (SOANap-SP) in a human bronchial epithelial cell line (BEAS-2B) residing at air–liquid interface. SOAβPin-SP mostly contained oxygenated aliphatic compounds from photooxidation, whereas SOANap-SP significant fraction aromatic products under similar conditions. Following exposure,...
Soot particles (SP) are ubiquitous components of atmospheric particulate matter and have been shown to cause various adverse health effects. In the atmosphere, freshly emitted SP can be coated by condensed low-volatility secondary organic inorganic species. addition, gas-phase oxidants may react with surface SP. Due chemical physical resemblance carbon backbone polyaromatic hydrocarbon species their potent oxidation products, we investigated biological responses BEAS-2B lung epithelial cells...
Ultrafine particles (UFP) are the smallest atmospheric particulate matter linked to air pollution-related diseases. The extent which UFP's physical and chemical properties contribute its toxicity remains unclear. It is hypothesized that UFP act as carriers for chemicals drive biological responses. This study explores robust methods generating reference understand these mechanisms perform toxicological tests. Two types of combustion-related with similar elemental carbon cores but different...
Pollen related allergic diseases have been increasing for decades. The reasons this increase are unknown, but environmental pollution like diesel exhaust seem to play a role. While previous studies explored the effects of pollen extracts, we studied here first time priming on native exposure using novel experimental setup. Human bronchial epithelial BEAS-2B cells were exposed birch (real life intact pollen, not extracts) at air-liquid interface (pollen-ALI). also pre-exposed in diesel-ALI...
Particularly since the wide-ranging health effects of asbestos exposure became known, great emphasis has been placed on detailed toxicity testing known but also newly developed fiber materials. Exposure to respirable pollutants like fibers can lead tissue injury causing lung diseases such as pulmonary fibrosis or cancer. In order detect toxic potential aerosols at an early stage, development suitable test systems is essential. this study, we illustrate advanced in vitro cell model closely...
Abstract The prevalence of allergic diseases is constantly increasing since few decades. Anthropogenic ultrafine particles (UFPs) and allergenic aerosols highly involved in this increase; however, the underlying cellular mechanisms are not yet understood. Studies observing these effects focused mainly on singular vivo or vitro exposures single particle sources, while there only limited evidence their subsequent combined effects. Our study aimed at evaluating effect to allergy‐related...
Abstract Allergic diseases are an increasing global burden. Epidemiological and in vivo studies showed that farming environments could protect from allergic asthma. Studies explaining this protective effect mainly focused on the influence of chemical compounds molecular size range proteins endotoxins. Our study aimed at deciphering possible role small-sized semi-volatile organic (SVOCs) aerosols immunomodulation processes. Bronchial epithelial BEAS-2B cells were exposed to aerosol extracts...
Abstract Especially through the release from anthropogenic sources, there is growing concern about human exposure to ultrafine particulate matter (UFP). Inhalation of UFP associated with respiratory diseases such as asthma, pulmonary fibrosis and lung cancer, but their mechanisms action are still vastly unknown. In this study we aimed address question whether physical characteristics contribute most toxicity or particles primarily act carriers toxic chemicals. For scope, two distinct...