A5072757687- Herpesvirus Infections and Treatments
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- Cytomegalovirus and herpesvirus research
- interferon and immune responses
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Brucella: diagnosis, epidemiology, treatment
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Immune responses and vaccinations
- Poxvirus research and outbreaks
- COVID-19 Impact on Reproduction
- Helicobacter pylori-related gastroenterology studies
- Respiratory viral infections research
- RNA regulation and disease
- Viral Infections and Outbreaks Research
- Microbial Metabolites in Food Biotechnology
- SARS-CoV-2 detection and testing
- Inflammasome and immune disorders
- Viral-associated cancers and disorders
- Urticaria and Related Conditions
- Viral Infections and Vectors
- Probiotics and Fermented Foods
- Bacterial Infections and Vaccines
University of Antofagasta
2022-2025
Pontificia Universidad Católica de Chile
2015-2025
Millennium Institute on Immunology and Immunotherapy
2016-2025
University of Concepción
2011-2016
Trained immunity is a type of non-specific memory-like immune response induced by some pathogens and vaccines, such as BCG, which can confer antigen-independent protection against wide variety pathogens. The BCG vaccine has been extensively used to protect tuberculosis for almost 100 years. Interestingly, this reduces children's mortality caused infections unrelated
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the distress condition known as COVID-19. This disease broadly affects several physiological systems, including gastrointestinal, renal, and central nervous (CNS) significantly influencing patient’s overall quality of life. Additionally, numerous risk factors have been suggested, gender, body weight, age, metabolic status, renal health, preexisting cardiomyopathies, inflammatory conditions. Despite advances in...
The ability of the human isolate Lactobacillus fermentum UCO-979C to form biofilm and synthesize exopolysaccharide on abiotic biotic models is described. These properties were compared with well-known casei Shirota better understand their anti-Helicobacter pylori probiotic activities. two strains lactobacilli synthesized as detected by Dubois method formed surfaces visualized crystal violet staining scanning electron microscopy. Concomitantly, these inhibited H. urease activity up 80.4%...
Multiple vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been evaluated in clinical trials. However, trials addressing the immune response pediatric population are scarce. The inactivated vaccine CoronaVac has shown to be safe and immunogenic a phase 1/2 trial cohort China. Here, we report interim safety immunogenicity results of 3 for healthy children adolescents Chile. Participants 17 years old received two doses 4-week interval until 31 December 2021....
Heme oxygenase-1 (HO-1) is an inducible enzyme that expressed in response to physical and chemical stresses, such as ultraviolet radiation, hyperthermia, hypoxia, reactive oxygen species (ROS), well cytokines, among others. Its activity can be positively modulated by cobalt protoporphyrin (CoPP) negatively tin protoporphirin (SnPP). Once induced, HO-1 degrades iron-containing heme into ferrous iron (Fe2+), carbon monoxide (CO) biliverdin. Importantly, numerous products of are cytoprotective...
Background:Mycobacterium bovis Bacillus Calmette-Guérin (BCG) is a live attenuated vaccine mainly administered to newborns and used for over 100 years prevent the disease caused by Mycobacterium tuberculosis (M. tb). This can induce immune response polarization towards Th1 profile, which desired counteracting M. tb, other mycobacteria, unrelated intracellular pathogens. The BCG has been as vector express recombinant proteins shown protect against several diseases, particularly respiratory...
Herpes simplex virus (HSV) type 1 (HSV-1) and 2 (HSV-2) produce lifelong infections that are associated with frequent asymptomatic or clinically apparent reactivation. Importantly, HSV express multiple virulence factors negatively modulate innate adaptive immune components. Notably, interfere dendritic cell (DC) viability function, likely hindering the capacity of host to mount effective immunity against these viruses. Recently, an HSV-2 was deleted in glycoprotein D engineered (designated...
One of the interventional strategies to reestablish immune effector/regulatory balance, that is typically altered in chronic inflammatory diseases (CID), reinforcement endogenous immunomodulatory pathways as one triggered by interleukin (IL)-10. In a recent work, we demonstrated subcutaneous (sc) administration an IL-10/Treg-inducing small molecule-based formulation, using repetitive microdose (REMID) treatment strategy preferentially direct effects regional system, delays progression...
Immune evasion by herpes simplex virusHerpes viruses and humans have co-existed for tens of thousands years.This long relationship has translated into the evolution selection viral determinants to evade host immune response reciprocally components limiting virus infection damage.Currently there are no vaccines available avoid with these or therapies cure them.Herpes neurotropic reside latently in neurons at trigeminal dorsal root ganglia, occasionally reactivating.Most recurrences...
Herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) infections are life-long highly prevalent in the human population. These viruses persist host, eliciting either symptomatic or asymptomatic that may occur sporadically a recurrent manner through viral reactivations. Clinical manifestations due to infection be mild such as orofacial lesions, but also translate into more severe diseases, ocular lead blindness life-threatening encephalitis. A key feature of herpes (HSVs) is they have evolved...
Herpes simplex virus type 2 (HSV-2) is highly prevalent in the human population producing significant morbidity, mainly because of generation genital ulcers and neonatal encephalitis. Additionally, HSV-2 infection significantly increases susceptibility host to acquire HIV promotes shedding latter coinfected. Despite numerous efforts create a vaccine against HSV-2, no licensed vaccines are currently available. A long-standing strategy, based on few viral glycoproteins combined with adjuvants,...
This study was conducted to evaluate the immunogenicity and protective efficacy of a DNA vaccine encoding Brucella abortus Cu,Zn superoxide dismutase (SOD) using Toll-like receptor 2/6 agonist S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy polyethylene glycol (BPPcysMPEG) as an adjuvant. Intranasal coadministration BPPcysMPEG with plasmid carrying SOD-encoding gene (pcDNA-SOD) into BALB/c mice elicited antigen-specific humoral cellular immune responses. Humoral responses...
Abstract Background Multiple vaccines against SARS-CoV-2 have been evaluated in clinical trials, but very few include the pediatric population. The inactivated vaccine CoronaVac ® has shown to be safe and immunogenic a phase 1/2 trial cohort China. This study is an interim safety immunogenicity report of 3 for healthy children adolescents Chile. Methods Participants aged 17 years old received two doses four-week interval. Local systemic adverse reactions were registered 699 participants that...