A5103149923- MRI in cancer diagnosis
- Renal cell carcinoma treatment
- Advanced MRI Techniques and Applications
- Renal and related cancers
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Cancer-related Molecular Pathways
- Telomeres, Telomerase, and Senescence
- DNA Repair Mechanisms
- RNA modifications and cancer
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Pregnancy and preeclampsia studies
- RNA Research and Splicing
- Cancer, Lipids, and Metabolism
- Acute Lymphoblastic Leukemia research
- Atomic and Subatomic Physics Research
- Estrogen and related hormone effects
- Acute Myeloid Leukemia Research
- Multiple Myeloma Research and Treatments
- Photoacoustic and Ultrasonic Imaging
- Advanced NMR Techniques and Applications
- Advanced X-ray and CT Imaging
- Nuclear Structure and Function
The University of Texas Southwestern Medical Center
2015-2025
Southwestern Medical Center
2013-2025
Advanced Imaging Research (United States)
2017-2025
Mayo Clinic
2024-2025
Mayo Clinic in Arizona
2025
Medanta The Medicity
2024
Bayer (United States)
2024
Medanta The Medicity
2022
All India Institute of Medical Sciences
2019
Houston Methodist
2015-2017
Cell-cycle phase is a critical determinant of the choice between DNA damage repair by nonhomologous end-joining (NHEJ) or homologous recombination (HR). Here, we report that double-strand breaks (DSBs) induce ATM-dependent MOF (a histone H4 acetyl-transferase) phosphorylation (p-T392-MOF) and phosphorylated colocalizes with γ-H2AX, ATM, 53BP1 foci. Mutation site (MOF-T392A) impedes in S G2 but not G1 cells. Expression MOF-T392A also blocks reduction DSB-associated seen wild-type S/G2 cells,...
The biological effects of ionizing radiation are attributable, in large part, to induction DNA double-strand breaks. We report here the identification a new protein factor that reconstitutes efficient break rejoining when it is added reaction containing five other polypeptides known participate human nonhomologous end-joining pathway. stable heteromeric complex polypyrimidine tract-binding protein-associated splicing (PSF) and 54-kDa nuclear RNA-binding (p54(nrb)). These polypeptides, which...
Checkpoint kinase inhibitors (CHKi) exhibit striking single-agent activity in certain tumors, but the mechanisms accounting for hypersensitivity are poorly understood. We screened a panel of 49 established human head and neck squamous cell carcinoma (HNSCC) lines report that nearly 20% hypersensitive to CHKi monotherapy. Hypersensitive cells underwent early S-phase arrest at drug doses sufficient inhibit greater than 90% CHK1 activity. Reduced rate DNA replication fork progression...
Dysregulated lipid and glucose metabolism in clear cell renal carcinoma (ccRCC) has been implicated disease progression, whole tumor tissue-based assessment of these changes is challenged by the heterogeneity. We studied a noninvasive quantitative MRI method that predicts metabolic alterations tumor.We applied Dixon-based for vivo quantification accumulation (fat fraction [FF]) targeted regions interest 45 primary ccRCCs correlated measures to mass spectrometry-based lipidomics metabolomics...
Abstract Purpose: Intratumoral heterogeneity (ITH) challenges the molecular characterization of clear cell renal carcinoma (ccRCC) and is a confounding factor for therapy selection. Most approaches to evaluate ITH are limited by two-dimensional ex vivo tissue analyses. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) can noninvasively assess spatial landscape entire tumors in their natural milieu. To potential DCE-MRI, we developed vertically integrated radiogenomics...
Abstract Glioblastoma is highly vascularized with increased perfusion and prognosis remains dismal, despite improved diagnosis aggressive multimodal treatment. The current standard of care maximal surgical resection when feasible, followed by adjuvant radiation concurrent chemotherapy, temozolomide. However, treatment resistance tumor recurrence pose a considerable challenge for stratifying patients optimal planning. Current radiological assessment glioblastoma therapy response predominantly...
Proliferating mammalian stem and cancer cells express telomerase [telomerase reverse transcriptase (TERT)] in an effort to extend chromosomal G-overhangs maintain telomere ends. Telomerase-expressing also have higher levels of the single-stranded DNA-binding protein SSB1, which has a critical role DNA double-strand break (DSB) repair. Here, we report that SSB1 binds specifically G-strand telomeric vitro associates with telomeres vivo. interacts TERT catalytic subunit regulates its...
Arterial spin labeled (ASL) MRI has gained recognition as a quantitative perfusion imaging method for managing patients with brain tumors. Limited studies have so far investigated the reproducibility of ASL-derived in This study aims to evaluate intrasession repeatability and intersession measurements using 3D pseudo-continuous ASL (pCASL) Cartesian TSE (TSE-CASPR) healthy volunteers (HV) glioblastoma (GBM) at 3 Tesla compare against pCASL GRASE.
Widespread use of screening mammography has recently increased the detection breast microcalcifications. These nonpalpable microcalcifications with specific features in tissues are clinically considered an early indicator carcinoma. Our goal this study was to develop a murine microcalcification model for optimizing vivo imaging. Recombinant human BMP-2 expressed E. coli, and purified bioactive protein used as inducing factor production animal model. Syngeneic tumors were obtained by...
Abstract Purpose To develop a portable MR perfusion phantom for quality‐controlled assessment and reproducibility of arterial spin labeled (ASL) measurement. Methods A 3D‐printed was developed that mimics the branching vessels, capillaries, chamber containing cellulose sponge representing tissue characteristics. peristaltic pump circulated distilled water through phantom, first evaluated at 300, 400, 500 mL/min. Longitudinal performed using 2D pseudo‐continuous ASL 20 post‐label delays...