A5086293556- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- Pharmacogenetics and Drug Metabolism
- Hemoglobinopathies and Related Disorders
- RNA modifications and cancer
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Gut microbiota and health
- Cancer-related molecular mechanisms research
- Drug Transport and Resistance Mechanisms
- Cancer therapeutics and mechanisms
- Genetic Associations and Epidemiology
- Cancer-related gene regulation
- RNA Research and Splicing
- Metabolomics and Mass Spectrometry Studies
- Glutathione Transferases and Polymorphisms
- Cardiovascular Health and Risk Factors
- Iron Metabolism and Disorders
- Computational Drug Discovery Methods
- Stress Responses and Cortisol
- BRCA gene mutations in cancer
- Genomics, phytochemicals, and oxidative stress
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
University of Tennessee Health Science Center
2017-2025
The University of Texas Health Science Center at Tyler
2019
University of Arkansas for Medical Sciences
2006-2016
University of Helsinki
2014
Office of the Director
2013
National Center for Toxicological Research
2007-2012
United States Food and Drug Administration
2010
Western University of Health Sciences
2008
Abstract Growing evidence highlights an association between imbalance in the composition and abundance of bacteria breast tissue (referred as microbial dysbiosis) cancer women. However, studies on microbiome have not been conducted non-Hispanic Black (NHB) We investigated normal microbiota from NHB White (NHW) women to identify distinct signatures by race, stage, or tumor subtype. Using 16S rRNA gene sequencing, we observed that phylum Proteobacteria was most abundant (n = 8), adjacent...
For African American or Hispanic women, the extent to which clinical breast cancer risk prediction models are improved by including information on susceptibility single nucleotide polymorphisms (SNPs) is unknown, even though these women comprise increasing proportions of US population and represent a large proportion world’s population. We studied 7539 3363 from Women’s Health Initiative. The age-adjusted 5-year risks BCRAT IBIS were measured combined with score based >70 independent SNPs....
The pace of aging varies between individuals and is marked by changes in DNA methylation (DNAm) including an increase randomness or entropy. Here, we computed epigenetic scores entropy using DNAm datasets from the Women's Health Initiative (WHI). We investigated how different metrics relate to demographic health variables, mortality risk. Income education, two proxies socioeconomics (SE), had consistent associations with Notably, stochastic increases at sites targeted polycomb proteins were...
Summary Cholesterol‐conjugated miRNA has emerged as a viable system for preventing small molecule degradation in plasma with low toxicity and high delivery efficiency. We previously established that miR‐29b induces fetal haemoglobin (HbF) Townes sickle cell anaemia (SCA) mice using continuous infusion mini‐osmotic pump. Herein, we expanded the scope of our work to determine ability intermittent subcutaneous cholesterol‐conjugated (Chol‐miR‐29b) induce HbF expression SCA mice. Blood was...
It is well established that transcriptional silencing of critical tumor-suppressor genes by DNA methylation a fundamental component in the initiation breast cancer. However, involvement microRNAs (miRNAs) restoring abnormal patterns cancer not understood. Therefore, we investigated whether miRNA-29b, due to its complimentarity 3'- untranslated region methyltransferase 3A (DNMT3A) and DNMT3B, could restore normal human cancers cell lines. We demonstrated transfection pre-miRNA-29b into less...
Abstract Racial disparities in survival among African American ( AA ) women the United States have been well documented. Breast cancer mortality rates is higher Memphis, Tennessee as compared to 49 of largest US cities. In this study, we investigated extent which racial/ethnic outcomes Memphis are attributed differences breast tumor subtype and treatment outcomes. A total 3527 patients diagnosed with stage I–IV between January 2002 April 2015 at Methodist Health hospitals West Cancer Center...
Breast cancer, the most common malignancy in women, emerges through a multistep process, encompassing progressive sequential evolution of morphologically distinct stages from normal cell to hyperplasia (with and without atypia), carcinoma situ, invasive metastasis. The success treatment breast cancer could be greatly improved by detection at early cancer. In present study, we investigated underlying molecular mechanisms involved carcinogenesis Augustus Copenhagen-Irish female rats, cross...
Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component suggested by data indicating its association with increased breast cancer. This study investigated the potential effects acrylamide nontumorigenic cells assessing expression levels inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) NOS activity, which are known to be early molecular changes disease formation. Treatment iNOS (both activity) Cox-2. Its...
Abstract Reports of an unanticipated increase in cancer risk following exposure to tamoxifen and estrogen-containing drugs suggest that long-term consequences genetic variations drug metabolism may need be elucidated more thoroughly during product development. Variations UGTs metabolize these result reduced efficacy estrogen target tissues, such as the breast women. In this study, we characterized expression normal (n = 31) malignant 17) human tissues from African American Caucasian Several...
Introduction: Acute myeloid leukemia (AML) is the most common type of in adults. However, there a gap understanding molecular basis disease, partly because key genes associated with AML have not been extensively explored. In current study, we aimed to identify that strong association based on cross-species integrative approach. Methods: We used Weighted Gene Co-Expression Network Analysis (WGCNA) co-expressed gene modules significantly correlated human AML, and further selected exhibiting...
Summary Sickle cell disease ( SCD ) affects over 2 million people worldwide with high morbidity and mortality in underdeveloped countries. Therapeutic interventions aimed at reactivating fetal haemoglobin (HbF) is an effective approach for improving survival ameliorating the clinical severity of . A class agents that inhibit DNA methyltransferase DNMT activity show promise as HbF inducers because off‐target effects are not observed low concentrations. However, these compounds rapidly...
Background: A high inflammatory and cytokine burden that induces vascular inflammation, myocarditis, cardiac arrhythmias, myocardial injury is associated with a lethal outcome in COVID-19. The SARS-CoV-2 virus utilizes the ACE2 receptor for cell entry similar way to SARS-CoV. This study investigates regulation, gene network, pathways of may be involved cardiovascular complications Methods: Cardiovascular traits were determined one largest mouse genetic reference populations: BXD recombinant...