A5035637744- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Global Cancer Incidence and Screening
- MicroRNA in disease regulation
- Nutrition, Genetics, and Disease
- Biomedical and Engineering Education
- Intensive Care Unit Cognitive Disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Health Literacy and Information Accessibility
- Interdisciplinary Research and Collaboration
- Cardiac Imaging and Diagnostics
- Public Health Policies and Education
- Anesthesia and Sedative Agents
- Fuel Cells and Related Materials
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Policing Practices and Perceptions
- Economic and Financial Impacts of Cancer
- Growth Hormone and Insulin-like Growth Factors
- Nutritional Studies and Diet
- Circular RNAs in diseases
- BRCA gene mutations in cancer
- Breast Cancer Treatment Studies
- Thyroid Disorders and Treatments
- Gun Ownership and Violence Research
Medical College of Wisconsin
2015-2025
Mayo Clinic in Arizona
2023
Office of Diversity and Inclusion
2022
Froedtert Hospital
2022
University of North Carolina Wilmington
2020
Stuart Olson (Canada)
2013-2017
American Society of Anesthesiologists
2014-2015
Zero to Three
2015
Novem (Netherlands)
2015
Environmental Protection Agency
2011
Recent studies in various animal models have suggested that anesthetics such as propofol, when administered early life, can lead to neurotoxicity. These raised significant safety concerns regarding the use of pediatric population and highlight need for a better model study anesthetic-induced neurotoxicity humans. Human embryonic stem cells are capable differentiating into any cell type represent promising mechanisms governing neurotoxicity.Cell death human cell-derived neurons was assessed...
Objective To investigate the effect of aromatherapy massage on pain intensity and maximal mouth opening (MMO) in patients with myogenous TMD.Methods Ninety-one were randomly assigned to three groups: Group L (aromatherapy lavender oil, test), group P (massage sweet almond placebo), C (control). Participants evaluated at T0 (before intervention), T1 (immediately after T2 (2-month follow-up). Data analyzed using one-way ANOVA, Tukey's HSD, Kruskal-Wallis tests.Results For T2, showed greatest...
Interdisciplinary research teams can be extremely beneficial when addressing difficult clinical problems. The incorporation of conceptual and methodological strategies from a variety disciplines health professions yields transformative results. In this setting, the long-term goal team science is to improve patient care, with emphasis on population outcomes. However, principles necessary for effective are rarely taught in professional schools. To form successful interdisciplinary...
Abstract The precursor form of the nerve growth factor (proNGF), forms a heterotrimeric complex with receptors p75 and sortilin; this has been implicated in neuron cell death. However, it is not known whether proNGF sortilin contribute to age‐ disease‐related neurodegeneration. Here we show that induces death subpopulations basal forebrain peripheral sympathetic neurons old, but young, adult rodents. In contrast, appears induce neurite outgrowth rather than young neurons. We have examined...
The role of microRNA-21 in isoflurane-induced cardioprotection is unknown. authors addressed this issue by using knockout mice and explored the underlying mechanisms.C57BL/6 were echocardiographically examined. Mouse hearts underwent 30 min ischemia followed 2 h reperfusion vivo or ex presence absence 1.0 minimum alveolar concentration isoflurane administered before ischemia. Cardiac Akt, endothelial nitric oxide synthase (eNOS), neuronal (nNOS) proteins determined Western blot analysis....
Abstract Background: Anesthetic cardioprotection reduces myocardial infarct size after ischemia–reperfusion injury. Currently, the role of microRNA in this process remains unknown. MicroRNAs are short, noncoding nucleotide sequences that negatively regulate gene expression through degradation or suppression messenger RNA. In study, authors uncovered functional microRNA-21 (miR-21) up-regulation anesthetic exposure. Methods: MicroRNA and RNA changes were analyzed by quantitative real-time...
A multi-institutional interdisciplinary team was created to develop a research group focused on leveraging artificial intelligence and informatics for cardio-oncology patients. Cardio-oncology is an emerging medical field dedicated prevention, screening, management of adverse cardiovascular effects cancer/ cancer therapies. Cardiovascular disease leading cause death in survivors. risk these patients higher than the general population. However, prediction prevention events individuals with...
Thyroid gland explant cultures from prometamorphic Xenopus laevis tadpoles were evaluated for their utility in assessing chemicals thyroid hormone (TH) synthesis disruption. The response of cultured glands to bovine stimulating (bTSH) and the TH inhibitors methimazole, 6-propylthiouracil, perchlorate was determined. continuously exposed 12 days graded concentrations bTSH released thyroxine (T4) a dose-dependent manner. Over time, appeared reach constant daily rate T4 release. This suggested...
Background: App-based technologies could enhance patient and caregiver communication provide alerts that potentially reducing readmissions. However, the burden of App needs to be optimized reduce provider burnout. Aim: The purpose this study was determine subjective objective using Patient Buddy App, a health information technology (HIT) on providers in randomized multicenter trial, who completed semi-quantitative Likert scale survey regarding training procedures, data privacy concerns,...
African Americans have a higher rate of cardiovascular morbidity and mortality lower specialty consultation treatment than Caucasians. These disparities also exist in the care chemotherapy-related complications. suffer from cardiotoxicity at Caucasians are underrepresented clinical trials aimed preventing injury associated with cancer therapies. To eliminate racial ethnic prevention cardiotoxicity, an interdisciplinary innovative approach will be required. Diverse forms digital...
Coarctation of the aorta (CoA) is a constriction proximal descending thoracic and one most common congenital cardiovascular defects. Treatments for CoA improve life expectancy, but morbidity persists, particularly due to development chronic hypertension (HTN). Identifying mechanisms difficult in humans confounding variables such as age at repair, follow-up duration, coarctation severity concurrent anomalies. We previously developed an experimental model that replicates aortic pathology with...
It is broadly recognised that women in the developing world are most negatively affected demographic as a result of anthropogenic climate change (Dankelman and Jansen, 2010; Denton, 2002). Wome...
Treatments for metastatic breast cancer (MBC) improve survival but often impose prolonged symptom burden. We performed molecular characterization of 84 miRNAs in the circulating serum women with MBC to explore possible early indicators intervention response. Expression levels miR-10a-5p and miR-211-5p were downregulated nonresponders, upregulated responders (miR-10a-5p: 0.40-fold eightfold; miR 211-5p: 0.47-fold fourfold). miR-205-5p expression was both nonresponders responders, a greater...
Significant disparities are apparent in geographic areas and among racial/ethnic minority groups Wisconsin. Cancer complex multifactorial require collaborative, multilevel efforts to reduce their impact. Our objective was understand cancer identify opportunities collaborate across community research sectors address them.From May 2017 through October 2018, we assembled of members researchers conducted 10 listening sessions 29 interviews with a total 205 participants from diverse backgrounds....
The genetic bases and disparate responses to radiotherapy are poorly understood, especially for cardiotoxicity resulting from treatment of thoracic tumors. Preclinical animal models such as the Dahl salt-sensitive (SS) rat can serve a surrogate model low renin hypertension, common African Americans, where aldosterone contributes hypertension-related alterations peripheral vascular renal function. Brown Norway (BN) rats, in comparison, normotensive control group, while consomic SSBN6 with...