A5082645067- Laser Applications in Dentistry and Medicine
- Nitric Oxide and Endothelin Effects
- Pregnancy and preeclampsia studies
- Photoreceptor and optogenetics research
- Cardiac Imaging and Diagnostics
- Medical and Biological Ozone Research
- Mechanical Circulatory Support Devices
- Cardiovascular Disease and Adiposity
- Atherosclerosis and Cardiovascular Diseases
- Connexins and lens biology
- Atrial Fibrillation Management and Outcomes
- Maternal and fetal healthcare
- Birth, Development, and Health
- Cardiac Arrhythmias and Treatments
- Cardiac Ischemia and Reperfusion
- Cerebrovascular and Carotid Artery Diseases
- Redox biology and oxidative stress
- Nutrition and Health in Aging
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Cardiac Fibrosis and Remodeling
- Anesthesia and Neurotoxicity Research
- Chemotherapy-induced cardiotoxicity and mitigation
- Kawasaki Disease and Coronary Complications
- Heart Failure Treatment and Management
University of Alabama at Birmingham
2023-2025
Milwaukee VA Medical Center
2004-2024
Birmingham VA Medical Center
2024
Medical College of Wisconsin
2015-2024
University of Alabama at Birmingham Hospital
2023
Froedtert Hospital
2022
University of Florida
2017
ThedaCare
2017
Cardiovascular Research Center
2010
Center for Vascular Biology Research
2010
Reactive oxygen species (ROS) mediate the effects of anesthetic precondition to protect against ischemia and reperfusion injury, but mechanisms ROS generation remain unclear. In this study, authors investigated if mitochondria-targeted antioxidant (mitotempol) abolishes cardioprotective preconditioning. Further, mechanism by which isoflurane alters in isolated mitochondria submitochondrial particles.
Background— Development of coronary collateral vessels is impaired in patients with diabetes mellitus. We tested the hypothesis that hyperglycemia alone attenuates development and abolishes proliferative properties myocardial interstitial fluid (MIF) by enhancing expression matrix metalloproteinases (MMP) angiostatin. Methods Results— Chronically instrumented dogs were randomly assigned to receive an infusion normal saline (control; n=9) or 70% dextrose water increase blood glucose 350 400...
Systemic sclerosis (SSc) is an autoimmune connective tissue disorder characterized by oxidative stress, impaired vascular function, and attenuated angiogenesis. The tight-skin (Tsk(-/+)) mouse a model of SSc that displays many the cellular features clinical disease. We tested hypotheses abnormal fibrillin-1 expression chronic phospholipid oxidation occur in Tsk(-/+) mice and, furthermore, these factors precipitate prooxidant state, collagen-related protein expression, apoptosis, mesenchymal...
Nonvalvular atrial fibrillation (NVAF) is a highly prevalent arrhythmia where loss of synchronized contraction increases the risk intracardiac thrombus particularly within left appendage (LAA). Anticoagulation mainstay stroke prevention based on CHA2 DS2 -VASc score; however, it does not account for LAA structural characteristics.The research comprises retrospective matched case-control study 196 subjects with NVAF who underwent transesophageal echo (TEE). The control group, without (n =...
Abstract We have previously established that 670 nm energy induces relaxation of blood vessels via an endothelium derived S -nitrosothiol (RSNO) suggested to be embedded in vesicles. Here, we confirm red light facilitates the exocytosis this vasodilator from cultured endothelial cells and increases ex vivo vessel diameter. Ex pressurized pre-constricted facial arteries C57Bl6/J mice relaxed 14.7% maximum diameter when immersed medium removed red-light exposed Bovine Aortic Endothelial Cells....
Nitric oxide dependent vasodilation is an effective mechanism for restoring blood flow to ischemic tissues. Previously, we established ex vivo murine model whereby red light (670 nm) facilitates via endothelium derived vasoactive species which contains a functional group that can be reduced nitric oxide. In the present study investigated this vasodilator in by measuring with Laser Doppler Perfusion imaging mice. The vasodilatory precursor was analyzed plasma and muscle triiodide-dependent...
Abstract The tight skin mouse (Tsk −/+ ) is a model of scleroderma characterized by impaired vasoreactivity, increased oxidative stress, attenuated angiogenic response to VEGF and production the angiogenesis inhibitor angiostatin. Low‐level light therapy (LLLT) stimulates in myocardial infarction chemotherapy‐induced mucositis. We hypothesize that repetitive LLLT restores vessel growth ischemic hindlimb Tsk mice attenuating angiostatin enhancing angiomotin effects vivo . C57Bl/6J underwent...
Coronary collateral development relies on the coordinated secretion of growth factors. However, alone they are insufficient for permanent growth. We utilized proteomics to identify other important proteins in extracellular environment that could facilitate collateralization. Chronically instrumented dogs developed coronary collaterals by repetitive occlusion method. Subendocardial (0.19 +/- 0.04, 0.27 0.06, 0.48 0.10, and 0.81 0.11 ml x min(-1) g(-1) days 1, 7, 14, 21, respectively)...
Abstract Background Cardiovascular disease (CVD) is the leading cause of death in women every major developed country and most emerging nations. Complications pregnancy, including preeclampsia, indicate a subsequent increase cardiovascular risk. There may be primary care provider knowledge gap regarding preeclampsia as risk factor for CVD. The objective our study to determine how often internists at an academic institution inquire about history compared smoking, hypertension diabetes, when...
There is significant therapeutic advantage of nitric oxide synthase (NOS) independent (NO) production in maladies where endothelium, and thereby NOS, dysfunctional. Electromagnetic radiation the red near infrared region has been shown to stimulate NOS-independent but NO-dependent vasodilation, potential. We have recently that light induces acute vasodilatation pre-constricted murine facial artery via release an endothelium derived substance. In this study we investigated mechanism conclude...
Interferon regulatory factor 5 (IRF5) has been called a “master switch” for its ability to determine whether cells mount proinflammatory or anti-inflammatory responses. Accordingly, IRF5 should be an attractive target therapeutic drug development. Here we report on the development of novel decoy peptide inhibitor that decreases myocardial inflammation and improves vascular endothelial cell (EC) function in tight-skin (Tsk/+) mice. Biolayer interferometry studies showed Kd IRF5D recombinant...
Vascular dysfunction is a hallmark of many diseases, including coronary heart disease, stroke, and diabetes. The underlying mechanisms these disorders are intimately associated with an increase in oxidative stress excess generation reactive oxygen species. Here, we report that the anionic free radical, superoxide (O2*- ), directly affects function ion channels vascular endothelial cells. cells were exposed to O2*- under physiological, symmetrical chloride chloride-free conditions. Superoxide...
The genetic bases and disparate responses to radiotherapy are poorly understood, especially for cardiotoxicity resulting from treatment of thoracic tumors. Preclinical animal models such as the Dahl salt-sensitive (SS) rat can serve a surrogate model low renin hypertension, common African Americans, where aldosterone contributes hypertension-related alterations peripheral vascular renal function. Brown Norway (BN) rats, in comparison, normotensive control group, while consomic SSBN6 with...