A5033791088- Advanced oxidation water treatment
- Lanthanide and Transition Metal Complexes
- Monoclonal and Polyclonal Antibodies Research
- Immunotherapy and Immune Responses
- Water Treatment and Disinfection
- Pharmaceutical and Antibiotic Environmental Impacts
- Radioactive element chemistry and processing
- Radiation Therapy and Dosimetry
- Glycosylation and Glycoproteins Research
- Pancreatic and Hepatic Oncology Research
- CAR-T cell therapy research
- Free Radicals and Antioxidants
- Metal complexes synthesis and properties
- Analytical chemistry methods development
- bioluminescence and chemiluminescence research
- Nuclear Materials and Properties
- Environmental remediation with nanomaterials
- Virus-based gene therapy research
- Immune cells in cancer
- Cancer Genomics and Diagnostics
- Childhood Cancer Survivors' Quality of Life
- Phagocytosis and Immune Regulation
- Sarcoma Diagnosis and Treatment
- Mass Spectrometry Techniques and Applications
- Radiation Detection and Scintillator Technologies
The University of Texas Southwestern Medical Center
2021-2025
California State University System
2007-2013
California State University, Long Beach
2007-2011
University of New Mexico
2010
Idaho National Laboratory
2010
University of Cincinnati
2010
Western Michigan University
2007
Pancreatic ductal adenocarcinoma (PDAC) is notably resistant to conventional chemotherapy and radiation treatment. However, clinical trials indicate that carbon ion radiotherapy (CIRT) with concurrent gemcitabine effective for unresectable locally advanced PDAC. This study aimed identify patient characteristics predictive of CIRT response. We utilized a panel human PDAC cell lines diverse genetic profiles determine their sensitivity compared γ-rays, assessing relative biological...
Absolute rate constants and degradation efficiencies for hydroxyl radical reactions with seven low-molecular-weight nitrosamines in water have been evaluated using a combination of electron-pulse radiolysis/absorption spectroscopy steady-state radiolysis/GCMS measure ments. The oxidation were found to depend upon nitrosamine size very good linear correlation the number methylene groups these compounds. This correlation, given by ln(k•OH) = (19.72 ± 0.14) + (0.424 0.033)(#CH2), suggests that...
<title>Abstract</title> The Axl receptor tyrosine kinase is pivotal for metastatic tumor progression, immune evasion, and regulating inflammation of innate cells. In this study we investigated Axl’s function in immunogenic tumors found that knockout (KO) mice exhibited a significant delay growth. Single-cell RNA sequencing revealed deficiency increases CD8 T cell activity. Tumor growth was dependent on cells BATF3 expression, indicating role dendritic (DC) cross priming activities....
Abstract The tumor landscape of pancreatic ductal adenocarcinoma (PDAC) is refractory to conventional photon radiotherapy (RT) due a fibrotic microenvironment (TME) that promotes chronic hypoxia and reduced immune surveillance. radiobiological factors unique carbon ion (CIRT), such as high linear energy transfer (LET) less dependence on oxygen, make it well-suited overcome the PDAC TME. Here, we utilized clonal syngeneic KPC cell lines tumors examine this postulate identify underlying impact...
In the rapidly advancing field of synthetic biology, there exists a critical need for technology to discover targeting moieties therapeutic biologics. Here we present INSPIRE-seq, an approach that utilizes nanobody library and next-generation sequencing identify nanobodies selected complex environments. INSPIRE-seq enables parallel enrichment immune cell-binding penetrate tumor microenvironment. Clone specificity vary across cell subtypes in tumor, lymph node, spleen. identifies dendritic...
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is inherently resistant to conventional chemo-and radiation-therapy. However, clinical trials showed that carbon ion radiotherapy (CIRT) with concurrent gemcitabine can be effective for treating unresectable locally advanced PDAC. In this study, we aimed determine features could identify patients who would benefit most from CIRT. A panel of human PDAC cell lines various genetic backgrounds was leveraged whether a subset identified...
Abstract The compound 1-(2,2,3,3,-tetrafluoropropoxy)-3-(4-sec-butylphenoxy)-2-propanol, also called Cs-7SB, is used as a solvent modifier in formulations containing calixarenes and crown ethers for cesium strontium extraction from nuclear waste solutions. solvates complexes of both metals decreases its concentration result lowered efficiency both. use Cs-7SB nuclear-solvent ensures that it will be exposed to high-radiation doses, thus radiation-chemical robustness matter interest the design...
Arrhenius parameters for the reactions of oxidizing hydroxyl radicals and reducing hydrated electrons with cisplatin, transplatin carboplatin in aqueous solution have been determined using pulsed electron radiolysis absorption spectroscopy techniques. Under physiological pH chloride concentration conditions, radical reaction rate constants (9.99 +/- 0.20) x 10(9), (8.38 0.55) (6.03 0.08) 10(9) M(-1) s(-1) at 24.0, 20.7 24.0 degrees C, respectively, corresponding activation energies 12.79...
Canine soft tissue sarcoma (STS) has served as a preclinical model for radiation, hyperthermia, experimental therapeutics, and tumor microenvironmental research decades. Stereotactic body radiotherapy (SBRT) demonstrates promising results the control of various tumors in human veterinary medicine; however, there is limited clinical data management STS with SBRT. In this retrospective study, we aimed to define overall efficacy toxicity SBRT treatment macroscopic canine establish comparative...
In support of the potential use advanced oxidation and reduction process technologies for removal carcinogenic nitro-containing compounds in water reaction rate constants hydroxyl radical hydrated electron with a series low molecular weight nitramines (R(1)R(2)-NNO(2)) have been determined using combination pulse radiolysis transient absorption spectroscopy. The constant was fast, ranging from 0.54-4.35 × 10(9) M(-1) s(-1), seen to increase increasing complexity nitramine alkyl substituents...
Temperature-dependent kinetics for the reactions of hydroxyl radicals and hydrated electrons with anti-cancer drug nedaplatin have been determined using a combination electron pulse radiolysis absorption spectroscopy. Under physiological pH chloride concentrations, was well described by equations [Formula: see text]and text]corresponding to Arrhenius activation energies 15.88 +/- 1.16 14.14 1.41 kJ mol(-1) radical oxidation reduction, respectively. Through comparison spectral kinetic...
Abstract Trivalent lanthanide/actinide separations from used nuclear fuel occurs in the presence radiation fields that degrades extraction ligands and solvents. Here we have investigated stability of a new ligand for separation; 2,6-bis[(di(2-ethylhexyl)phosphino)methyl] pyridine N,P,P-trioxide, TEH(NOPOPO). The impact γ-radiolysis on distribution ratios actinide (Am) Lanthanide (Eu) both absence an acidic aqueous phase by TEH(NOPOPO) was determined. Corresponding reaction rate constants two...
Abstract In the rapidly advancing field of synthetic biology, there is a critical need for technology to discover targeting moieties therapeutic biologics. We developed INSPIRE-seq, an approach that utilizes nanobody library and next-generation sequencing identify nanobodies selected complex environments. INSPIRE-seq enables parallel enrichment immune cell-binding penetrate tumor microenvironment. Clone specificity varies across cell subtypes in tumor, lymph node, spleen. identified...