A5051647634- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Urologic and reproductive health conditions
- Radiomics and Machine Learning in Medical Imaging
- MRI in cancer diagnosis
- Advanced MRI Techniques and Applications
- Bladder and Urothelial Cancer Treatments
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Photoacoustic and Ultrasonic Imaging
- AI in cancer detection
- IgG4-Related and Inflammatory Diseases
- Medical Imaging Techniques and Applications
- Urinary Bladder and Prostate Research
- Renal and Vascular Pathologies
- Hormonal and reproductive studies
- Cancer, Lipids, and Metabolism
- Renal Transplantation Outcomes and Treatments
- Neuroendocrine Tumor Research Advances
- Adipose Tissue and Metabolism
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
University of California, Los Angeles
2015-2025
Stanford University
2023
Ronald Reagan UCLA Medical Center
2013-2022
UCLA Health
2020-2021
Los Angeles Medical Center
2018-2020
Nieuwegein Fonds
2018
University of California System
2018
University of Geneva
2018
Robert Bosch (Netherlands)
2018
Hôpital Beau-Séjour
2015
<h3>Importance</h3> Magnetic resonance imaging (MRI) guidance improves the accuracy of prostate biopsy for detection clinically significant cancer, but optimal use such is not yet clear. <h3>Objective</h3> To determine cancer rate (CDR) targeting MRI-visible lesions vs systematic sampling in diagnosis men who were naive. <h3>Design, Setting, and Participants</h3> This paired cohort trial, known as Prospective Assessment Image Registration Diagnosis Prostate Cancer (PAIREDCAP) study, was...
The purpose of this study was to differentiate clear cell renal carcinoma (RCC) from other solid masses on four-phase MDCT.Our cohort included all pathologically proven that underwent pretreatment MDCT at our institution 2001 2012. Both retrospective qualitative analysis (blinded dual-radiologist evaluation morphologic features: enhancement pattern, lesion contour, neovascularity, and calcification) quantitative (mean absolute relative attenuation changes in across phases) were performed....
We assessed whether changes in serial multiparametric magnetic resonance imaging can help predict the pathological progression of prostate cancer men on active surveillance.A retrospective cohort study was conducted 49 consecutive with Gleason 6 who underwent at baseline and again more than months later, each followed by a targeted biopsy, between January 2011 May 2015. evaluated (an increase index lesion suspicion score, volume or decrease apparent diffusion coefficient) could (Gleason 3 +...
The role of prostate-specific membrane antigen (PSMA)-targeted PET in comparison to mpMRI the evaluation intraprostatic cancer foci is not well defined. aim our study was compare diagnostic performances PSMA PET/CT, and PET/CT+mpMRI using 3 independent blinded readers for each modality with histopathology as gold standard detection, intra-prostatic localization local extension primary prostate cancer. <b>Methods:</b> Patients intermediate- or high-risk who underwent a PET/CT part prospective...
The purpose of this study is to compare the diagnostic accuracy liver apparent diffusion coefficient (ADC) versus normalized ADC using spleen as a reference organ for diagnosis fibrosis and cirrhosis.Fifty-six patients, 34 with disease 22 control subjects, were assessed breath-hold single-shot echo-planar diffusion-weighted imaging b values 0, 50, 500 s/mm(2). Liver (defined ratio ADC) compared between patients stratified by stage. Receiver operating characteristic (ROC) analysis was used...
Focal laser ablation is a potential treatment in some men with prostate cancer. Currently focal performed by radiologists magnetic resonance imaging unit (in bore). We evaluated the safety and feasibility of performing urology clinic (out bore) using imaging-ultrasound fusion for guidance.A total 11 intermediate risk cancer were enrolled this prospective, institutional review board approved pilot study. Magnetic was used to guide fibers transrectally into regions interest harboring Thermal...
Abstract Background Partial gland ablation (PGA) is a new option for treatment of prostate cancer (PCa). Cryotherapy, an early method PGA, has had favorable evaluations, but few studies have employed strict protocol using biopsy endpoints in men with clinically significant (csPCa). Methods 143 unilateral csPCa were enrolled prospective, observational trial outpatient PGA‐cryotherapy. Treatment was 2‐cycle freeze the affected part. Participants evaluated MRI‐guided (MRGB) at baseline and 6...
The objective of our study was to determine the clinical and MRI characteristics clinically significant prostate cancer (PCA) (Gleason score ≥ 3 + 4) in men with Prostate Imaging Reporting Data System version 2 (PI-RADSv2) category transition zone (TZ) lesions.From 2014 2016, 865 underwent MRI/ultrasound (US) fusion biopsy (FB). A subset 90 FB-naïve 96 PI-RADSv2 TZ lesions identified. Patients were imaged at T using a body coil. Images assigned by an experienced radiologist. Using data...
Oncologic efficacy of focal therapies in prostate cancer depends heavily on accurate tumor size estimation. We aim to evaluate the agreement between radiologic and pathological size, identify predictors size.This single arm study cohort included all consecutive patients with biopsy proven a corresponding PI-RADS®v2 3 or greater index multiparametric magnetic resonance imaging who subsequently underwent radical prostatectomy. Radiologic was defined as maximum diameter compared whole mount...
No AccessJournal of UrologyAdult Urology1 Sep 2021Optimizing Spatial Biopsy Sampling for the Detection Prostate Cancer Alex G. Raman, Karthik V. Sarma, Steven S. Alan M. Priester, Sohrab Afshari Mirak, Hannah H. Riskin-Jones, Nikhil Dhinagar, William Speier, Ely Felker, Anthony E. Sisk, David Lu, Adam Kinnaird, Robert Reiter, Leonard Marks, and Corey W. Arnold RamanAlex Raman Computational Diagnostics Lab, Geffen School Medicine, University California, Los Angeles, California Equal study...
Abstract Micro-ultrasound has recently been introduced as a low-cost alternative to multi-parametric MRI for imaging prostate cancer. Early clinical studies have demonstrated promising results; however, robust validation via comparison with whole-mount pathology yet be achieved. Due micro-ultrasound probe design and tissue deformation during scanning, it is difficult accurately correlate planes ground truth slides. In this study, we developed multi-step methodology co-register pathology. The...
Several deep learning-based techniques have been developed for prostate cancer (PCa) detection using multiparametric magnetic resonance imaging (mpMRI), but few of them rigorously evaluated relative to radiologists' performance or whole-mount histopathology (WMHP).To compare the a previously proposed learning algorithm, FocalNet, and expert radiologists in PCa on mpMRI with WMHP as reference.Retrospective, single-center study.A total 553 patients (development cohort: 427 patients; evaluation...
Multiparametric magnetic resonance imaging and biopsy based molecular tests such as the 17-gene Oncotype DX® Genomic Prostate Score™ assay are increasingly performed to improve risk stratification in men with clinically localized prostate cancer. The score was previously shown be a significant independent predictor of adverse pathology findings at radical prostatectomy diagnosed by systematic biopsies only. Therefore, we investigated ability predict setting guided biopsy.We identified NCCN®...
Background/Objectives: This study evaluated metabolites and lipid composition in the calf muscles of Type 2 diabetes mellitus (T2DM) patients age-matched healthy controls using multi-dimensional MR spectroscopic imaging. We also explored association between muscle metabolites, lipids, intra-abdominal fat T2DM. Methods: Participants included 12 T2DM (60.3 ± 8.6 years), 9 (AMHC) (60.9 7.8 10 young (YHC) (28.3 1.8 years). acquired 2D spectra an enhanced accelerated 5D echo-planar correlated...
We aimed to determine if, using baseline MRI-guided biopsy (MRGB), durability of active surveillance (AS) could be pre-determined, follow-up biopsies avoided, and if by incorporating focal therapy (FT), AS extended. A cohort 869 men in the UCLA protocol study (2010-2022) was analyzed. Inclusion criteria were (MRGB) showing Grade Group (GG) ≤ 2 >1 year enrollment. After 2016, FT offered with GG2 those progressing GG3. The accrued 3500 patient-years (median 4.1 years). At baseline, GG1 (505),...