Hantaviruses are rodent/insectivore-borne negative-stranded RNA viruses which belong to the Bunyaviridae family. They do not cause any symptomatic disease in their adult carrier rodents, but humans they aetiologic agents of haemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary (HPS), both associated a significant mortality. In cell culture hantaviruses cytopathic effects mechanisms man well understood. Increased capillary permeability is central phenomenon pathogenesis...

Reverse transcription-PCR was used to analyze specimens from 20 Finnish nephropathia epidemica (NE) patients hospitalized during the period October 1994 January 1995. Blood and/or urine sediment seven were found be positive for genome sequences of Puumala hantavirus (PUU). PCR positivity correlated well with HLA-DRB1*0301 and HLA B8 alleles, which previously shown associate severe courses NE. Genetic analysis partial M-and/or S-segment obtained three severely ill NE revealed PUU strains...

A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles (Microtus arvalis and M. rossiaemeridionalis) by RT-PCR was obtained after initial passaging TUL-infected vole lung samples laboratory-colonized arvalis. TUL defined as classical serotype cross-focus-reduction neutralization test (FRNT) also shown to be distinct from other hantaviruses haemagglutination inhibition assay. The sequences S, M partial L genome segments the were determined: S...

OBJECTIVE To assess repeatability and agreement of the House‐Brackmann (H‐B FGS) Sunnybrook (SFGS) Facial Grading Systems. STUDY DESIGN AND SETTING Eight video‐recorded facial palsy patients were graded in 2 sittings by 28 doctors. Repeatability for SFGS measured intraclass correlation coefficient (ICC) (CR), H‐B FGS percentage kappa coefficients. RESULTS was from good to excellent fair good. Agreement between doctors moderate CR nearly perfect ICC. For FGS, 50%, generalized indicated only...

Netherton syndrome (NS) is a rare and severe genodermatosis caused by SPINK5 mutations leading to the loss of lymphoepithelial Kazal-type-related inhibitor (LEKTI). characterized neonatal scaling erythroderma, bamboolike hair defect, substantial skin barrier profound atopic diathesis. has been proposed be primary immunodeficiency because high frequency infections. The precise mechanisms underlying disease are not fully understood.To study association mutation with NS phenotype extent...

Objectives To study the correlation between Sunnybrook and House‐Brackmann facial grading systems at different time points during course of peripheral palsy. Study Design Prospective multicenter trial. Setting Seventeen otorhinolaryngological centers. Subjects Methods Data are part Scandinavian Bell’s palsy study. The function 1920 patients with was assessed 5397 times both (H‐B) systems. Grading done initial visit, days 11 to 17 onset, 1 month, 2 months, 3 6 12 months. Statistical...

Objective: To study whether prednisolone reduces sequelae in Bell's palsy.Design: Prospective, randomized, double-blind, placebocontrolled, multicenter trial with 12 months of follow-up.Setting: Seventeen referral centers.Patients: In all, 829 patients aged 18 to 75 years.Interventions: Randomization within 72 hours a factorial fashion placebo plus (n = 206); prednisolone, 60 mg/d for 5 days, the dosage then tapered 210); valacyclovir hydrochloride, 1000 mg 3 times daily 7 (n=207); or...

Clin. Otolaryngol. 2012, 37 , 283–290 Objectives: To evaluate the treatment effect of prednisolone and/or valaciclovir in Bell’s palsy patients with different baseline severity palsy. Design: Patient data were collected from Scandinavian Palsy Study, a prospective, randomised, double‐blind, placebo‐controlled, multi‐centre trial. Setting: Sixteen otorhinolaryngological centres Sweden and one Finland. Participants: Altogether, 829 aged 18–75 years treated within 72 h onset. Patients randomly...

Objective: To evaluate if treatment start and age are related to the outcome in Bell's palsy patients treated with prednisolone. Study Design: Prospective, randomized, double-blind, placebo-controlled, multicenter trial. Setting: Sixteen otorhinolaryngologic centers Sweden 1 Finland. Patients Data were collected from Scandinavian study. A total of 829 within 72 hours onset palsy. Follow-up was 12 months. Intervention: randomly assigned placebo plus (n = 206), prednisolone 210), valacyclovir...

Abstract Purpose To explore the characteristics, medical treatments, and long-term facial palsy outcome in Ramsay Hunt syndrome. Methods Patient questionnaire including self-assessment of retrospective chart review. Initial grade was compared to self-assessed or patient record stated outcome. Occurrence different characteristics (blisters, hearing loss, vertigo, etc.) syndrome were assessed. Results Altogether 120 patients included which 81 answered questionnaire. All but one had received...

Abstract Background Laryngomalacia is the most common congenital airway anomaly causing breathing difficulties in infants. Severe laryngomalacia often associated with obstructive sleep apnea (OSA). Methods We re-evaluated 14-year pediatric center polysomnography (PSG) data infants fluoroscopy-verified laryngomalacia. Results The study included 79 infants, a median corrected age of 8 weeks (interquartile range, IQR 5–13) and clinical score 10/14 (IQR 7–11). Most (78%) PSG studies were daytime...

(1998). High-producer Allele of Tumour Necrosis Factor-Alpha is Part the Susceptibility MHC Haplotype in Severe Puumala Virus-induced Nephropathia Epidemica. Scandinavian Journal Infectious Diseases: Vol. 30, No. 5, pp. 532-534.

To study characteristics of Melkersson-Rosenthal syndrome (MRS) patients with facial palsy (FP) and differences in treated at the Departments Otorhinolaryngology Dermatology.Clinical picture MRS was studied from patient charts two departments. Patients FP received a questionnaire were examined. Tissue biopsies searched for non-necrotizing granulomatous infiltrations typical blood DNA UNC-93B1 gene mutations predisposing to herpesvirus infection.At Department Otorhinolaryngology, all 18 had...

Microbiologic causes of facial palsy in children were investigated.Prospective clinical study.Tertiary referral center.Forty-six aged 0 to 16 years with peripheral palsy.Paired serum samples and cerebrospinal fluid tested find indications microbes associated palsy. The herpes simplex virus 1 2, varicella-zoster virus, human herpesvirus-6, Mycoplasma pneumoniae, Borrelia burgdorferi, influenza A B picorna, cytomegalovirus, parainfluenza respiratory syncytial coxsackie B5 adenovirus,...

Conclusion: Most patients benefitted from immediate facial nerve grafting after radical parotidectomy. Even weak movement is valuable and can be augmented with secondary static operations. Post-operative radiotherapy does not seem to affect the final outcome of function. Objectives: During parotidectomy, sacrifice results in severe disfigurement face. Data on principles reconstruction reanimation parotidectomy are limited no consensus exists best practice. Method: This study retrospectively...

To evaluate the effect of prednisolone and valacyclovir on ipsilateral pain around ear in face or neck Bell's palsy. The incidence intensity during first 2 months palsy its prognostic value were also assessed.Prospective, randomized, double-blind, placebo-controlled, multicenter trial.Sixteen tertiary referral centers Sweden 1 Finland.Data are part Scandinavian study; 829 patients aged 18 to 75 years with onset within 72 hours included. Follow-up time was 12 months.Patients assigned 4...

In Finland, occurrence of Klebsiella pneumoniae carbapenemase-producing K. (KPC-KP) has previously been sporadic and related to travel. We describe the first outbreak colonisation with KPC-KP strain ST512; it affected nine patients in a 137-bed primary care hospital. The index case was detected by chance when non-prescribed urine culture taken from an asymptomatic patient suprapubic urinary catheter June 2013. Thereafter, all on 38-bed ward were screened until two screening rounds negative...

On 18 October 2007, the first case of Clostridium difficile PCR ribotype 027-associated disease was detected in Finland.

Herpes simplex virus 1 (HSV-1) and varicella-zoster (VZV) DNA were not detected in the cerebrospinal fluid (CSF) of patients with acute idiopathic peripheral facial palsy (Bell's palsy). Our results indicate either absence these viruses or presence technical shortcomings. The role human herpesvirus 6 (HHV-6) this disorder significance a positive HHV-6 finding central nervous system need further investigation.Our goal was to determine whether HSV-1, VZV, can be found by polymerase chain...