The relationship between reduced pulmonary function in early life and persistent wheeze (PW) school-aged children remains uncertain. In this study, VmaxFRC was assessed at 1 month of age, the presence up to 11 years age prospectively identified. At airway responsiveness (AR) inhaled histamine atopy were assessed. Recent associated with a mean z score for (-0.41 [SD 0.91], n = 31) compared no recent (0.04 1.00], 153, p 0.03). Wheeze 4 6 that persisted most prevalent among those aged (p 0.002)...

Asthma is the most common chronic childhood disease in developed nations. Little known about relationship between airway responsiveness infancy and development of asthma later life. The at 1 mo with asthma, atopy, lower respiratory symptoms, lung function 6 yr age was investigated prospectively 95 white children from a randomly ascertained birth cohort. Baseline spirometry, to histamine, skin reactivity allergens were assessed yr. Total serum immunoglobulin E (IgE) measured cord blood Blood...

Tumour necrosis factor alpha (TNFalpha) is a potent modulator of immune and inflammatory responses, has been implicated in variety autoimmune diseases, including asthma. Increased levels TNFalpha have detected both sputa bronchoalveolar lavage fluid asthmatic subjects during acute attacks. Interindividual variation may be genetically determined polymorphisms within the TNF genes nearby HLA Class II region associated with differences production.To investigate association asthma-related...

Several quantitative traits associated with the asthma phenotype have been linked to markers on chromosome 11q13, although gene responsible has yet be well established. The for Clara cell secretory protein (CC16) is an ideal candidate involvement in inherited predisposition because of its chromosomal location, role CC16 controlling airway inflammation, and differences levels between asthmatics healthy controls. All three exons were screened unselected population 266 subjects from 76 families...

Asthma is a genetically complex disease, and the investigation of putative linkages to candidate loci in independent populations an important part gene discovery process. This study investigated linkage microsatellite markers 5q 11q regions asthma-associated quantitative traits 121 Australian Caucasian nuclear families. The families were recruited on basis child proband: cohort 95 randomly unselected probands (n = 442 subjects) 26 selected severe symptomatic asthma 134 subjects). assessed...

Within a longitudinal study of lung function in 243 infants, we identified group 23 individuals with flow limitation tidal expiration. In infancy, flow-limited children have reduced and increased airway responsiveness (AR), at 2 years age they are diagnosed asthma more frequently. We hypothesized that these observations would persist throughout childhood. Data from ages 3 to 11 were analyzed. Only 4 did the wheeze compared other cohort members (odds ratio, 4.25; 95% confidence interval [CI],...

Abstract A case-crossover study was undertaken to investigate the relationship between daily air pollutant concentrations and hospitalizations for selected disease categories in Perth, Western Australia. Daily measurements of particles (measured by nephelometry PM2.5), photochemical oxidants as ozone), nitrogen dioxide (NO2) carbon monoxide (CO) were obtained from 1992 1998 via a metropolitan network monitoring stations. PM2.5 estimated using monitored data, modelling interpolation. Hospital...

We have previously reported a relationship between increased airway responsiveness (AR) in infancy and reduced childhood lung function.The current study aimed to determine whether the Arg16Gly polymorphism of beta2 adrenoceptor (beta2AR) gene was important this relationship.A cohort that initially numbered 253 individuals underwent assessments AR function aged 1 month, 6 11 years; genotyping for polymorphisms beta(2)AR performed.At month age, genotype homozygous Arg16 (n=24) associated with...

Two cross-sectional studies explored the relationship between age and individuals' desire for control both on a general day-to-day level as patients in health care situations. The expectancies over also was examined. In Study 1, questionnaire surveys completed by 246 community adults ranging from 19 to 77 indicated that health-specific measures at older ages, belief internal are lower, powerful others is higher. contrast, no significant differences desires were found across groups. 2,...

Summary Background Reduced levels of interferon gamma (IFNγ) mRNA and protein have been detected in the bronchoalveolar lavage fluid atopic asthmatics. IFNγ is secreted by TH 1 cells while IL‐4 IL‐5 are 2 an imbalance /TH response may be responsible for asthma. The gene IFN4gM located on chromosome 12; a region genome which has shown linkage studies to associated with Objective To determine if there any mutations present coding exons 5’flanking asthmatic subjects compared controls explain...

Abstract The factors which determine the crystalline and air bubble structures of accreted ice have recently been elucidated. It is now possible to ascertain growth histories hailstones approximately spherical symmetry from studies their internal structure. In principle this analysis can be extended oblate once aerodynamic behaviour known. Six large 4 6.5cm maximum dimension, two each three severe storms, analysed. orientation distributions sizes crystals in hailstone layers indicate that...

Increased airway responsiveness (AR) is associated with asthma, but not all individuals increased AR have asthma. The aim of this study was to identify factors, other than physician-diagnosed asthma (PDA), which are AR. In a longitudinal study, data were collected on atopy and lower respiratory tract illness (LRTI) in infancy, (expressed as dose–response slope (DRS)), atopy, tobacco-smoke exposure PDA childhood. At age 6 yrs, DRS assessed 102 children, whom 22 (22%) had PDA; the...

Asthma is a genetically complex disease, and characterized by elevated serum immunoglobulin E (IgE) levels, blood eosinophil counts increased airway responsiveness. Polymorphisms in the beta subunit of high affinity receptor for IgE (FcepsilonR1-beta) have been previously associated with these phenotypes an risk asthma.To investigate association all known bi-allelic polymorphisms FcepsilonR1-beta to asthma quantitative traits selected sample Australian asthmatic children their nuclear...

Abstract Studies have been made of the crystallographic orientation 100μm‐radius supercooled droplets frozen on ice substrates whose c‐axis orientations varied from 0 to 90° surface normal. For a given droplet temperature and substrate orientation, there is critical below which has high ( > 0·8) probability having an differs that substrate. Above this small < 0·2) residual reorientation dependent but independent temperature. The lengths maximum widths crystals in accreted deposits also...

An association between birth order and IgE sensitization or allergic diseases has been reported in many studies.To assess the effect of age on relationship reduced increased to test hypothesis that this would decline with increasing age.As part a cohort study, common allergens was determined by skin prick testing at ages 6 12 months, 11 years.The original numbered 253 individuals whom 96 (38%) were first born. Compared older siblings, first-born had (odds ratio (OR) 2.4 [95% confidence...

Measurements of c- and c′-axis orientation distributions in accreted ice deposits formed the dry growth regime show peaks which may be related to conditions. Theoretical studies factors governing development equilibrium crystallographic such have been made. These that surface roughness affects sharpness both types distributions. In addition, distribution position peak is shifted hence cannot uniquely If inferences environment hailstones are made from crystal measurements, c-axes relative...

The c-axis orientation distributions of ice formed by the accretion supercooled droplets have been determined for a wide range air and deposit temperatures. There are peaks in which may be related to temperature. Consequently, quantitative information on growth environment hailstone can obtained from its crystallographic structure.

Abstract Two cases are reported of coagulopathy in association with the administration piperacillin to patients cystic fibrosis. In both was associated development a serum sickness‐like illness fever, rash and abnormal liver function tests occurring on day 12 16 treatment, respectively. On withdrawal piperacillin, sickness resolved rapidly, without sequelae.

Interleukin-5 (IL-5) is a potential candidate gene in the pathogenesis of asthma, as it main cytokine controlling eosinophil activity and eosinophils are pivotal development airway inflammation. Mutation detection studies were performed on IL-5 α-chain its receptor 30 asthmatic nonasthmatic subjects. Single-strand conformational polymorphism (SSCP) heteroduplex analysis (HA) did not reveal any change from reported normal sequence all 4 exons well promoter 3′-untranslated regions gene. No...

During the America's Cup race series of 1986–1987, a numerical sea breeze model was used to assist offshore forecasts. The exercise has provided detailed insight into extent which such may forecasting process parameterizations necessary, and factors that limit its accuracy. It also demonstrated some controlling behavior Western Australian breeze.