A5082483465- Photoacoustic and Ultrasonic Imaging
- Nanoplatforms for cancer theranostics
- Analytical Chemistry and Sensors
- Thermography and Photoacoustic Techniques
- Infrared Thermography in Medicine
- Osteoarthritis Treatment and Mechanisms
- Gas Sensing Nanomaterials and Sensors
- Photodynamic Therapy Research Studies
- Toxin Mechanisms and Immunotoxins
- Advancements in Transdermal Drug Delivery
- Extracellular vesicles in disease
- Bone health and osteoporosis research
- CAR-T cell therapy research
- Acne and Rosacea Treatments and Effects
- Ultrasound and Hyperthermia Applications
- Optical Imaging and Spectroscopy Techniques
- Immune Cell Function and Interaction
- Nutritional Studies and Diet
- Advanced Chemical Sensor Technologies
- Pharmacological Effects of Natural Compounds
- Folate and B Vitamins Research
- Galectins and Cancer Biology
- Birth, Development, and Health
AbbVie (United States)
2023-2025
University of Michigan
2017-2020
Michigan United
2017-2020
University of Toronto
2014-2018
Ion-selective optodes (ISOs), the optical analog of ion-selective electrodes, have played an increasingly important role in chemical and biochemical analysis. Here we extend this technique to photoacoustic (ISPAOs) that serve at same time as fluorescence-based ISOs, apply it specifically potassium (K+). Notably, ion is one most abundant cations biological systems, involved numerous physiological pathological processes. Furthermore, has been recently reported presence abnormal extracellular...
Abstract Cytokine therapies have been shown to be efficacious but are largely limited in their utility due toxicity issues. Systemic IL-15 is not well tolerated humans as it induces CRS patients with melanoma and renal cancer. To address systemic toxicity, we designed a nectin-4 targeted conditional immuno-cytokine (IC) that limits bioactivity targets the tumor microenvironment (TME). The hypothesis will enhance anti-tumor efficacy supported by data demonstrates ∼ 80 % complete response rate...
Lifetime imaging methods using phosphorescence quenching by oxygen for molecular concentration measurement have been developed and used noninvasive monitoring. This study reports photoacoustic (PA) powered polyacrylamide (PAAm) hydrogel nanoparticles (NP) which offer advantages including improved biocompatibility, reduced toxicity, active tumor targeting. A known indicator, oxyphor G2, was conjugated with the matrix of NPs, giving G2-PAA followed PEGylation biocompatibility F3 surface...
We used ultrasound (US) and photoacoustic (PA) imaging modalities to characterize cattle trabecular bones. The PA signals were generated with an 805-nm continuous wave laser for optimally deep optical penetration depth. detector both was a 2.25-MHz US transducer lateral resolution of ∼1 mm at its focal point. Using pixel size much larger than the trabeculae, raster scanning images related averaged values thermoelastic properties, as well density measurements in volume. backscatter yielded...
The accumulation of potassium (K
Clofazimine (CFZ) is a broad spectrum antimycobacterial agent recommended by the World Health Organization as first line treatment for leprosy and second multidrug resistant tuberculosis. Oral administration of CFZ leads to red skin pigmentation side effect. Since weakly basic, phenazine dye, effect results from lipophilic partitioning circulating, free base (neutral) form into skin. Here, we developed stable biocompatible formulation CFZ-HCl microcrystals that mimics predominant drug...
We describe how 4-dimensional in vivo biochemical analysis can be performed using photoacoustic contrast nanoagents that have been designed to probe both structural and chemical information vivo, enabling noninvasive, real time, spatially resolved imaging. Early imaging of a patient's tumor inform the decision effective treatment, regarding choices chemotherapy, radiation, or immunotherapy.
Abstract With the capability of presenting endogenous tissue contrast or exogenous agents in deep biological samples at high spatial resolution, photoacoustic (PA) imaging has shown significant potential for many preclinical and clinical applications. However, due to strong background signals from various intrinsic chromophores tissue, such as hemoglobin, achieving highly sensitive PA targeting probes labeled by remained a challenge. In this study, we introduce novel technique called...
Fortification of foodstuffs with folic acid is mandatory in many countries. Although the effect reducing neural tube defects utero well accepted, questions have been raised about possible adverse effects higher intakes on adult health. An increase colorectal cancer and some other cancers has postulated. As part a larger fortification monitoring program Australia, we conducted systematic review trials for these outcomes. We found 26 using between 0.420mg acid/day which reported all-cause...
Prostate cancer was the most common form and had second highest death rate of male in United States 2015. Current diagnosis techniques, such as prostate-specific antigen tests, transrectal ultrasound scans, biopsies, are often inconclusive, latter case, invasive. Here, we explore use clofazimine hydrochloride nanoparticles (CFZ-HCl NPs), a repurposed formulation from an FDA-approved antimycobacterial agent, photoacoustic contrast agent for evaluation prostate due to its macrophage-targeting...
This study examines the sensitivity and specificity of backscattered ultrasound (US) backscattering photoacoustic (PA) signals for bone composition variation assessment. The conventional approach in evaluation health relies on measurement mineral density (BMD). Although, a crucial probably most important parameter, BMD is not only factor defining health. New trends osteoporosis research, also pursue changes collagen content cross-links with diseases aging. Therefore, any non-invasive method...
In vivo photoacoustic (PA) imaging with high spatial resolution and depth penetration has remained a challenge due to the background signal from chromophores in biological tissue. this study, we introduce novel technique called triplet differential (TD) which allows for substantial reduction of signals TD uses ability molecules enter state via intersystem crossing an excited singlet state. Molecules exhibit spectral shift their optical absorption spectra, creating two separate peaks each...
Recently, Eil et al. showed that tumors with necrotic cores had elevated K+ concentrations due to the release of by necrosis, which acts suppress T-cell function high extracellular concentration. These findings demonstrate importance developing a tool for imaging distributions. Here, we nanosensor-enabled photoacoustic measuring levels in vivo. The nanosensor is an in-house synthesized optical contrast agent sensitive within biological ranges. use this nanosensor, combined multi-spectral...