A5071038030- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- MicroRNA in disease regulation
- Neurogenesis and neuroplasticity mechanisms
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Tryptophan and brain disorders
- Child and Adolescent Psychosocial and Emotional Development
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Resilience and Mental Health
- Birth, Development, and Health
- Early Childhood Education and Development
- RNA regulation and disease
- Regulation of Appetite and Obesity
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Eating Disorders and Behaviors
- Genetics, Aging, and Longevity in Model Organisms
- Circular RNAs in diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Biochemical Analysis and Sensing Techniques
- Hearing, Cochlea, Tinnitus, Genetics
- Genetics and Neurodevelopmental Disorders
Sapienza University of Rome
2016-2025
Fondazione Santa Lucia
2015-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2013-2023
University of L'Aquila
2013-2016
European Brain Research Institute
2008-2015
Abstract The mechanisms of communication between the brain and immune cells are still largely unclear. Here, we characterize populations resident natural killer (NK) innate lymphoid (ILC) 1 in meningeal dura layer adult mice. We describe that ILC1/NK cell-derived interferon-γ acetylcholine can contribute to modulation homeostatic functions, shaping synaptic neuronal transmission neurotransmitter levels with effects on mice behavior. In detail, plays a role formation non-spatial memory,...
Stress-related psychiatric disorders, including anxiety, are complex diseases that have genetic, and environmental causes. Stressful experiences increase the release of prefrontal amygdala neurotransmitters, a response is relevant to cognitive, emotional, behavioral coping. Moreover, exposure stress elicits anxiety-like behavior dendritic remodeling in amygdala. Members miR-34 family been suggested regulate synaptic plasticity neurotransmission processes, which mediate stress-related...
Coping is defined as the behavioral and physiological effort made to master stressful situations. The ability cope with stress leads either healthy or pathogenic outcomes. medial prefrontal cortex (mpFC) amygdala are acknowledged having a major role in stress-related behaviors, mpFC has critical regulation of amygdala-mediated arousal response emotionally salient stimuli. Prefrontal cortical serotonin (5-hydroxytryptamine (5-HT)) involved corticolimbic circuitry, GABA functioning. Here,...
Evidence shows that maternal care and postnatal traumatic events can exert powerful effects on brain circuitry development but little is known about the impact of early experiences processing rewarding aversive stimuli related to medial prefrontal cortex (mpFC) function in adult life. In this study, unstable environment induced by repeated cross-fostering (RCF) impaired palatable food conditioned place preference disrupted natural for sweetened fluids saccharin test. By contrast, RCF...
Although phenylketonuria (PKU) is the most common genetic cause of mental retardation, cellular mechanisms underlying impaired brain function are still unclear. Using PAHenu2 mice (ENU2), mouse model PKU, we previously demonstrated that high phenylalanine levels interfere with tryptophan hydroxylase activity by reducing availability serotonin (5-hydroxytryptamine, 5-HT), crucial for maturation neuronal connectivity in prefrontal cortex (PFC), around third postnatal week, a critical period...
Highlights•Platelets are key link in body-brain communication homeostasis•Platelets tune parvalbumin neuron activity and long-term potentiation the hippocampus•Natural killer cells release IL-13 gut with effects on serotonin uptake by platelets•Platelets NK fear memory miceSummarySeveral lines of evidence have shown that platelet-derived factors molecules brain-body pathological conditions. Here, we identify platelets as actors modulation behaviors mice through control inhibitory...
Adult early treated hyperphenylalaninaemic patients can show specific deficits of prefrontal cortical functions. The development additional therapeutic strategies for these requires the understanding mechanisms involved in phenylalanine-dependent impairment fronto-cortical We tested hypothesis phenylalanine interference with aminergic neurotransmission cortex by evaluating, vivo, amine release adult Pahenu2 mice, genetic model phenylketonuria. Mice healthy background responded to a...
Methods:Here, using mice from 2 inbred strains widely exploited in behavioral neurochemistry, we investigated whether serotonin transmission medial prefrontal cortex and GABA basolateral amygdala determine strain-dependent liability to stress response differences coping.
Early postnatal events exert powerful effects on development, inducing persistent functional alterations in different brain network, such as the catecholamine prefrontal–accumbal system, and increasing risk of developing psychiatric disorders later life. However, a vast body literature shows that interaction between genetic factors early environmental conditions is crucial for expression psychopathologies adulthood. We evaluated long-lasting repeated cross-fostering (RCF) procedure 2 inbred...
Phenylketonuria (PKU) is an inherited metabolic disease characterized by plasma hyperphenylalaninemia and several neurological symptoms that can be controlled rigorous dietetic treatment. The cellular mechanisms underlying impaired brain functions are still unclear. It has been proposed, however, phenylalanine interference in cognitive depends on dopamine (DA) transmission the prefrontal cortical area due to reduced availability of precursor tyrosine. Here, using Pah(enu2) (ENU2) mice,...
Background Eating disorders appear to be caused by a complex interaction between environmental and genetic factors, compulsive eating in response adverse circumstances characterizes many disorders. Materials Methods We compared compulsion-like the form of conditioned suppression palatable food-seeking situations stressed C57BL/6J DBA/2J mice, two well-characterized inbred strains, determine influence gene-environment interplay on this behavioral phenotype. Moreover, we tested hypothesis that...
Hyperphenylalaninemia (HPA) refers to all clinical conditions characterized by increased amounts of phenylalanine (PHE) in blood and other tissues. According their PHE concentrations under a free diet, hyperphenylalaninemic patients are commonly classified into phenotypic subtypes: classical phenylketonuria (PKU) (PHE > 1200 µM/L), mild PKU 600-1200 µM/L) persistent HPA 120-600 (normal < 120 µM/L). The current treatment for is aimed keep levels within the safe range 120-360 µM/L through...
Exposure to aversive events during sensitive developmental periods can affect the preferential coping strategy adopted by individuals later in life, leading either stress-related psychiatric disorders, including depression, or well-adaptation future adversity and sources of stress, a behavior phenotype termed "resilience". We have previously shown that interfering with development mother-pups bond Repeated Cross Fostering (RCF) stress protocol induce resilience depression-like adult C57BL/6J...
Phenylketonuria (PKU) is the most common genetic metabolic disease with a well-documented association autism spectrum disorders. It characterized by deficiency of phenylalanine hydroxylase activity, causing plasmatic hyperphenylalaninemia and variable neurological cognitive impairments. Among potential pathophysiological mechanisms implicated in disorders excitation/inhibition (E/I) imbalance which might result from alterations excitatory/inhibitory synapse development, synaptic transmission...