A5003613652- Retinal Diseases and Treatments
- Retinal and Optic Conditions
- Retinal Imaging and Analysis
- Glaucoma and retinal disorders
- Ocular Diseases and Behçet’s Syndrome
- Retinal and Macular Surgery
- Retinal Development and Disorders
- Optical Coherence Tomography Applications
- Intraocular Surgery and Lenses
- Cerebral Venous Sinus Thrombosis
- Retinopathy of Prematurity Studies
- Ophthalmology and Visual Impairment Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Traumatic Ocular and Foreign Body Injuries
- Climate Change and Health Impacts
- Autoimmune and Inflammatory Disorders
- Connexins and lens biology
- Cytomegalovirus and herpesvirus research
- Syphilis Diagnosis and Treatment
- Ocular and Laser Science Research
- Vasculitis and related conditions
- Vascular Malformations Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Circadian rhythm and melatonin
- Drug-Induced Ocular Toxicity
Tokyo Women's Medical University
2016-2025
Novartis (Switzerland)
2017
Pfizer (United States)
2017
Bayer (United States)
2017
Santen (Japan)
2017
Nara Medical University
2013-2016
Vitreous Retina Macula Consultants of New York
2016
Topcon (Japan)
2016
Tokyo Women's Medical University Hospital
2016
Columbia University
2016
Abstract This multicenter study aimed to assess the short-term effectiveness and safety of faricimab in treatment-naïve patients with wet age-related macular degeneration (wAMD) Japan. We retrospectively reviewed 63 eyes 61 wAMD, including types 1, 2, 3 neovascularization as well polypoidal choroidal vasculopathy (PCV). Patients received three consecutive monthly intravitreal injections loading therapy. Over these months, visual acuity improved gradually compared baseline. Moreover, central...
To report a case of intraocular inflammation (IOI) after intravitreal injection aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration. An 80-year-old man with diabetes mellitus had degeneration refractory to treatment 2 mg. Despite ten injections faricimab, the exudation remained, and we switched brolucizumab, which resulted in mild IOI. The IOI improved only topical steroids, back exudation. However, decided switch careful discussion patient. Two weeks...
<h3>Purpose</h3> To determine the choroidal thickness (CT) in macular area of eyes children with hyperopic anisometropic amblyopia and to compare that fellow age-matched controls. <h3>Materials methods</h3> Twenty-five patients (6.6±2.2 years, mean±SD) twenty controls (6.7±1.9 years) were studied. The CT was measured enhanced depth imaging programme a spectral domain optical coherence tomographic instrument all subfoveal at 1 mm 3 diameter around fovea determined. In addition, correlation...
To compare the efficacy of subthreshold micropulse laser (SML) to conventional (CL) in treating focal leakages retinal pigment epithelium (RPE) eyes with central serous chorioretinopathy (CSC).Twenty-nine 28 patients CSC and typical leakage were treated CL or SML. Both treatments made a 577 nm yellow (CL: NIDEK MC-500, SML: IRIDEX IQ577). The percentage complete resolution, distance burns from fovea, injury RPE after treatment studied.A resolution was seen 10 15 (66.7%) 9 14 (64.3%) SML (P =...
To report the 2-year outcomes of intravitreal aflibercept injections (IAIs) in Japanese patients with neovascular age-related macular degeneration (AMD) using a 1-month adjusted treat-and-extend (TAE) regimen.Multicenter, prospective, nonrandomized, interventional study.Ninety-seven eyes 97 treatment-naive AMD were studied at 3 tertiary ophthalmological institutions.The treated consecutive monthly IAIs followed by TAE regimen adjustment for maximum months. Our allowed us to shorten and...
Abstract To determine the clinical properties of pachychoroid neovasculopathy (PNV) that differ from conventional neovascular age-related macular degeneration (nAMD) and suggest they are different entities. accomplish this, we reviewed medical records 100 consecutive patients diagnosed with nAMD. All were Japanese, their mean age was 75.5 years. There 72 men 28 women. For bilateral cases, only right eye analyzed. An PNV when a neovascularization (MNV) detected just above dilated choroidal...
Abstract This multicentre retrospective study evaluated the 1-year outcomes and safety profile of faricimab in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Fifty-five (57 eyes) underwent loading therapy comprising three monthly injections. If dryness was achieved by third month, subsequent treat-and-extend (TAE) follow-up continued at a minimum 8-week interval thereafter. wet macula persisted fourth dose administered, followed TAE regimen. After 1 year,...
To examine the foveal structure and vasculature in eyes with an idiopathic epiretinal membrane (ERM).Forty-nine of 48 patients ERM were studied. The superficial avascular zone (FAZ) was measured by optical coherence tomography angiography (OCTA; RTVue XR Avanti, Optovue Inc., Fremont, CA), central thickness (CFT) swept source OCT (DRI-OCT, Topcon, Japan). Twenty underwent vitrectomy internal limiting (ILM) peeling, FAZ CFT evaluated pre- postoperatively. Forty-nine 49 age-matched healthy...
To determine whether a significant correlation exists between the presence of bulge in photoreceptor inner segment/outer segment line and best-corrected visual acuity eyes after successful rhegmatogenous retinal detachment (RRD) repair.Patients who had undergone RRD repair an intact at central fovea spectral-domain optical coherence tomographic images were retrospectively studied. Thirty-five 35 patients evaluated, classified preoperatively into those with macula-on (n = 14) macula-off 21)....
To determine the relationship between clinical findings and response to ranibizumab therapy in eyes with macular edema associated branch retinal vein occlusion.We reviewed medical records of 68 patients a occlusion. The were placed refractory group if central foveal thickness remained more than 250 μm throughout 6-month study period despite therapy; otherwise, they responsive group.Sixty (88.2%) other 8 (11.8%) group. At pretreatment examination, fluorescein angiography showed extensive...
Purpose: To evaluate the foveal granular reflexes (Jampol dots) in macula with multiple evanescent white dot syndrome (MEWDS) and describe pathophysiology. Methods: Eighteen eyes of 18 MEWDS cases (4 male,14 female) were studied. We evaluated presence location Jampol dots classified them into micro fused types based on fundus appearance, mixed type was included type. The findings optical coherence tomography (OCT) en face OCT investigated. A normal also analyzed. Results: seen (83%) 15 eyes:...
Aim To determine whether there is a significant correlation between the reduction in macular vessel density and recurrence of oedema eyes with branch retinal vein occlusion (BRVO). Methods We reviewed medical records 27 associated BRVO. All had received pro re nata intravitreal ranibizumab (IVR) injection. A reinjection was performed when central foveal thickness ≥300 µm. At 12 months, patients without additional IVR for last 4 months were placed resolved group, otherwise they group. The 3×3...
To visualize choroidal blood flow in larger vessels highly myopic eyes using a phenomenon of the projection artifact to sclera optical coherence tomography angiography.The retrospective study included 92 (54 patients) with greater than 8 diopters myopia. All were examined angiography (RTVue XR Avanti; Optovue Inc, Fremont, CA). The was evaluated by attempting directly segment choroid and also placing segmentation layer behind choroid, within sclera. Subfoveal thickness measured at same time....
Purpose: To report the effects of aflibercept on eyes with large retinal pigment epithelial detachment (PED) associted polypoidal choroidal vasculopathy (PCV). Methods: We reviewed medical records patients PEDs associated PCV that were treated after intravitreal ranibizumab had failed. Results: Three aged 72, 79, and 80 years studied. Reflective material was seen in PED along outer surface epithelium (RPE) by spectral-domain optical coherence tomography (SD-OCT). A complete resolution serous...
To determine the thickness of fovea in eyes children with anisohypermetropic amblyopia, their fellow and age-matched controls. Additionally, to assess effects optical treatment on foveal amblyopia.Twenty-one patients (6.0±2.3 years, mean±SD) amblyopia 25 controls (5.6±1.9 years) were studied. Spectral-domain coherence tomography (SD-OCT) was used obtain OCT images. The outer nuclear layer (ONL), photoreceptor inner segment (IS) (OS) measured by embedded software.The length OS significantly...
To determine whether there are factors that can predict the frequency of recurrences macular oedema associated with branch retinal vein occlusion (BRVO).We reviewed medical records 31 eyes treatment-naïve BRVO. All received an intravitreal ranibizumab (IVR) injection and were followed a pro re nata protocol for at least 12 months. A reinjection ranibizmab was performed when central foveal thickness ≥300 µm. At 1 month after IVR injection, vessel reduction calculated by comparing density in...
Objective: To describe longitudinal retinal changes in two cases of isolated paracentral acute middle maculopathy (PAMM). Case series: We reported (64 and 67-year-old men) with PAMM, who were followed-up for over 5 2.5 years, respectively. Both exhibited similar clinical natural histories. The first examinations took place several days after onset, funduscopy showing that both scotoma good visual acuity small gray lesions, while optical coherence tomography (OCT) showed the presence a...
Optical coherence tomography angiography (OCTA) seems not to image the choroidal blood flow pattern in normal individual because of OCT light attenuation. Our purpose current study was visualize large after subtraction choriocapillaris projection artifact eyes non-invasively by swept source (SS) OCTA. Sixty-one 45 individuals (19 men, 26 women) without ocular disease were examined SS-OCTA (AngioPlex Elite 9000, Zeiss, Germany). A 12 × mm macular area scanned. Subfoveal thickness (SCT)...