A5019490824- Retinal Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Glaucoma and retinal disorders
- Retinal Development and Disorders
- Ocular Diseases and Behçet’s Syndrome
- Cytomegalovirus and herpesvirus research
- Cerebral Venous Sinus Thrombosis
- Biomedical Research and Pathophysiology
- Thermal Regulation in Medicine
- Cellular transport and secretion
- Leaf Properties and Growth Measurement
- Intraocular Surgery and Lenses
- Greenhouse Technology and Climate Control
- Smart Agriculture and AI
Tokyo Women's Medical University
2019-2025
Nagoya University
2014-2017
Abstract This multicenter study aimed to assess the short-term effectiveness and safety of faricimab in treatment-naïve patients with wet age-related macular degeneration (wAMD) Japan. We retrospectively reviewed 63 eyes 61 wAMD, including types 1, 2, 3 neovascularization as well polypoidal choroidal vasculopathy (PCV). Patients received three consecutive monthly intravitreal injections loading therapy. Over these months, visual acuity improved gradually compared baseline. Moreover, central...
To compare the 1-year results of initial or deferred photodynamic therapy (PDT) combined with intravitreal ranibizumab (IVR) for eyes polypoidal choroidal vasculopathy.Prospectively, 72 men treatment-naive vasculopathy were randomized to later PDT IVR. In both groups, 2 additional monthly IVR followed. From Month 3, and administered according retreatment criteria. Mean changes in best-corrected visual acuity between baseline 12 central retinal thickness, rate showing regression lesions,...
To report a case of intraocular inflammation (IOI) after intravitreal injection aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration. An 80-year-old man with diabetes mellitus had degeneration refractory to treatment 2 mg. Despite ten injections faricimab, the exudation remained, and we switched brolucizumab, which resulted in mild IOI. The IOI improved only topical steroids, back exudation. However, decided switch careful discussion patient. Two weeks...
To evaluate the long-term efficacy and factors involved in recurrence persistence of subretinal fluid (SRF) after half-dose photodynamic therapy (PDT) for chronic central serous chorioretinopathy (CSC).In this retrospective observational case series, 79 eyes (73 patients) with CSC were treated PDT followed up at least 3 years. They divided into successful (64 eyes) unsuccessful (15 groups based on SRF absorption disease one session. Age, best-corrected visual acuity (BCVA), foveal thickness,...
Abstract To determine the clinical properties of pachychoroid neovasculopathy (PNV) that differ from conventional neovascular age-related macular degeneration (nAMD) and suggest they are different entities. accomplish this, we reviewed medical records 100 consecutive patients diagnosed with nAMD. All were Japanese, their mean age was 75.5 years. There 72 men 28 women. For bilateral cases, only right eye analyzed. An PNV when a neovascularization (MNV) detected just above dilated choroidal...
Abstract This multicentre retrospective study evaluated the 1-year outcomes and safety profile of faricimab in treatment-naïve patients with neovascular age-related macular degeneration (nAMD). Fifty-five (57 eyes) underwent loading therapy comprising three monthly injections. If dryness was achieved by third month, subsequent treat-and-extend (TAE) follow-up continued at a minimum 8-week interval thereafter. wet macula persisted fourth dose administered, followed TAE regimen. After 1 year,...
To elucidate the clinical characteristics and progression rate of geographic atrophy (GA) associated with age-related macular degeneration (AMD) in a Japanese population.Retrospective, multicenter, observational study.A total 173 eyes from patients 6 university hospitals Japan were included. Of study eyes, 101 included follow-up group. All Japanese, aged ≥ 50 years had definite GA AMD at least 1 eye.The area was measured semiautomatically using fundus autofluorescence (FAF) images. In group...
Purpose To diagnose central serous chorioretinopathy (CSC) by deep learning (DL) analyses of en face images the choroidal vasculature obtained optical coherence tomography (OCT) and to analyze regions interest for DL from heatmaps. Methods One-hundred eyes were studied; 53 with CSC 47 normal eyes. Volume scans 12×12 mm square at same time as OCT angiographic (OCTA) (Plex Elite 9000 Swept-Source ® , Zeiss). High-quality segmentation slab one-half subfoveal thickness created analyses. The 100...
PurposeTo elucidate the clinical characteristics and progression rates of pachychoroid conventional geographic atrophy (GA).DesignRetrospective, multicenter, observational study.ParticipantsA total 173 eyes from patients (38 with GA 135 GA) six university hospitals in Japan were included. All Japanese, aged ≥ 50 years fundus autofluorescence (FAF) images having analyzable image quality. A 101 (22 79 included follow-up group.MethodsThe studied classified as or GA; former was diagnosed if eye...
To determine how different intraoperative surgical procedures affect the midvitreous temperature.The vitreous temperatures were monitored continuously with an intravitreal thermocouple in 87 eyes of 81 cases undergoing vitrectomy. Thirty-three had diabetic retinopathy (DR), 35 epiretinal membrane, and 19 idiopathic macular hole. In DR, correlation between number photocoagulations (PCs) change temperature was analyzed. The also recorded before after combined phacoemulsification aspiration...
The purpose of this paper is to report choroidal atrophy in a patient with cancer-associated retinopathy who had autoantibodies against the transient receptor potential cation channel, subfamily M, member 1 (TRPM1). A 69-year-old man visited our clinic July 2010 complaints blurred vision and night blindness both eyes. full-field electroretinograms were negative type, indicating ON bipolar cell dysfunction. General physical examination revealed small carcinoma lung, Western blot patient's...
<b><i>Purpose:</i></b> We compared 1-year outcomes of 1 + pro re nata (PRN) versus 3 PRN intravitreal aflibercept injection (IAI) for age-related macular degeneration (AMD). <b><i>Methods:</i></b> Forty-two eyes with naïve AMD received IAI treatment and 47 treatment. Visual acuity (VA), central retinal thickness (CRT), choroidal (CCT) number administered IAIs during 12 months were compared. <b><i>Results:</i></b> VAs...
In Brief Purpose: To evaluate the relationship between morphological changes and functional improvements assessed using focal macular electroretinograms after intravitreal aflibercept (IVA) injections in eyes with wet age-related degeneration. Methods: The clinical records of 42 consecutive patients naive, degeneration received 3 monthly IVA were reviewed. best-corrected visual acuity, central foveal thickness, outer retinal inner thickness at baseline 1 month each IVA, first third compared....
<title>Abstract</title> <bold>Background</bold> To report a case of intraocular inflammation (IOI) after intravitreal injection aflibercept 8 mg for treatment-refractory neovascular age-related macular degeneration.<bold>Case presentation</bold> An 80-year-old man with diabetes mellitus had degeneration refractory to treatment 2 mg. Despite ten injections faricimab, the exudation remained, and we switched brolucizumab, which resulted in mild IOI. The IOI improved only topical steroids, back...
Purpose To determine the blood flow pattern of eyes before development type 3 macular neovascularization (MNV) by optical coherence tomography angiography (OCTA). Study design Retrospective study. Subjects Ten 10 patients (4 men and 6 women, mean age 80.4 years) diagnosed with unilateral Type MNV who developed in fellow normal eye during follow-up period were studied. Methods The time onset was defined as when retinal exudation detected OCT. a x mm or area deep capillary plexus (DCP) outer...
Abstract Purpose To classify central serous chorioretinopathy (CSC) by deep learning (DL) analyses of en face images choroidal vasculature obtained optical coherence tomography (OCT) and to analyze the regions interest for DL from heatmaps. Methods One-hundred eyes were studied; 53 with CSC 47 normal eyes. Volume scans 12×12 mm square at same time as OCT angiographic (OCTA) (Plex Elite 9000 Swept-Source ® , Zeiss). High-quality segmentation slab one-half subfoveal thickness created analyses....