A5046112844- Cancer Cells and Metastasis
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- Cancer, Hypoxia, and Metabolism
- Nanoparticle-Based Drug Delivery
- Systemic Sclerosis and Related Diseases
- PI3K/AKT/mTOR signaling in cancer
- Cancer Diagnosis and Treatment
- Cancer therapeutics and mechanisms
- Healthcare during COVID-19 Pandemic
- Adipose Tissue and Metabolism
- Magnetic Properties and Synthesis of Ferrites
- Cancer Mechanisms and Therapy
- Mesenchymal stem cell research
- Histone Deacetylase Inhibitors Research
- Thyroid Cancer Diagnosis and Treatment
- Genomics, phytochemicals, and oxidative stress
- 3D Printing in Biomedical Research
- Colorectal Cancer Treatments and Studies
- Phytochemicals and Antioxidant Activities
- Dermatologic Treatments and Research
- Cancer Immunotherapy and Biomarkers
- Microbial Metabolites in Food Biotechnology
- Periodontal Regeneration and Treatments
- Immune cells in cancer
University of Palermo
2017-2025
Cancer stem cells are responsible for tumour spreading and relapse. Human epidermal growth factor receptor 2 (HER2) expression is a negative prognostic in colorectal cancer (CRC) potential target tumours carrying the gene amplification. Our aim was to define of HER2 (CR-CSCs) its possible role as therapeutic CRC resistant anti- (EGFR) therapy.A collection primary sphere cell cultures obtained from 60 specimens used generate CR-CSC mouse avatars preclinically validate options. We also made...
Abstract Obesity is a strong risk factor for cancer progression, posing obesity-related as one of the leading causes death. Nevertheless, molecular mechanisms that endow cells with metastatic properties in patients affected by obesity remain unexplored. Here, we show IL-6 and HGF, secreted tumor neighboring visceral adipose stromal (V-ASCs), expand colorectal (CR) cell compartment (CD44v6 + ), which turn secretes neurotrophins such NGF NT-3, recruits stem within mass. Visceral...
Abstract Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in lineage hierarchy that serves as origin for different TC histotypes unknown. Human embryonic stem cells (hESCs) with appropriate vitro stimulation undergo sequential differentiation into thyroid progenitor (TPCs-day 22), which maturate thyrocytes (day 30). Here, we create follicular cell-derived TCs all based on specific genomic alterations delivered by CRISPR-Cas9 hESC-derived TPCs....
In many tumors, the tumor suppressor TP53 is not mutated, but functionally inactivated. However, mechanisms underlying p53 functional inactivation remain poorly understood. SETD8 sole enzyme known to mono-methylate on lysine 382 (p53K382me1), resulting in inhibition of its pro-apoptotic and growth-arresting functions. We analyzed p53K382me1 expression clinical colorectal cancer (CRC) inflammatory bowel disease (IBD) samples. Histopathological examinations, RNA sequencing, ChIP assay...
The use of stem cells, including mesenchymal cells (MSCs), for regenerative medicine is gaining interest the clinical benefits so far obtained in patients. This study investigates adipose autologous tissue combination with platelet-rich plasma (PRP) to improve outcome patients affected by systemic sclerosis (SSc). Adipose-derived (AD-MSCs) and PRPs were purified from healthy donors SSc multilineage differentiation potential AD-MSCs their genotypic–phenotypic features investigated. A cytokine...
Limited therapeutic options are available for advanced colorectal cancer (CRC). Herein, we report that exposure to a neo-synthetic bis(indolyl)thiazole alkaloid analog, nortopsentin 234 (NORA234), leads an initial reduction of proliferative and clonogenic potential CRC sphere cells (CR-CSphCs), followed by adaptive response selecting the CR-CSphC-resistant compartment. Cells spared treatment with NORA234 express high levels CD44v6, associated constitutive activation Wnt pathway. In...