A5100524661- Congenital heart defects research
- Analytical chemistry methods development
- Cancer, Hypoxia, and Metabolism
- Wastewater Treatment and Nitrogen Removal
- Analytical Chemistry and Chromatography
- Advanced biosensing and bioanalysis techniques
- Pharmaceutical and Antibiotic Environmental Impacts
- Tissue Engineering and Regenerative Medicine
- Ubiquitin and proteasome pathways
- Biosensors and Analytical Detection
- Metabolism and Genetic Disorders
- Extracellular vesicles in disease
- Antibiotics Pharmacokinetics and Efficacy
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- MicroRNA in disease regulation
- Microbial Metabolism and Applications
- Electrochemical sensors and biosensors
- Mass Spectrometry Techniques and Applications
- Congenital Heart Disease Studies
- Pharmacological Effects and Toxicity Studies
- Water Treatment and Disinfection
- Pulmonary Hypertension Research and Treatments
- Growth Hormone and Insulin-like Growth Factors
Huazhong University of Science and Technology
2022-2025
Guangxi University
2022-2025
Tianjin Medical University General Hospital
2024-2025
Jiangxi Agricultural University
2022-2024
Agricultural Product Processing Research Institute
2024
Johns Hopkins University
2022-2023
Johns Hopkins All Children's Hospital
2022-2023
Wenzhou Medical University
2023
Wuhan Textile University
2022
Wenzhou City People's Hospital
2016-2022
Previous studies have suggested that microRNAs (miRNAs) may play important roles in tumorigenesis, but little is known about the functions of most miRNAs cancer development. In present study, we set up a cell-based screen using luciferase reporter plasmid carrying whole approximately 4.7 kb 3'-UTR estrogen receptor alpha (ERalpha) mRNA cotransfected with synthetic miRNA expression library to identify potential ERalpha-targeting miRNAs. Among all miRNAs, miR-22 was found repress robustly...
ABSTRACT Given the effectiveness of organic pollutants photodegradation and excellent photovoltaic nature solar cells (OSCs), this work first innovatively integrated cross‐fields OSCs environmental photocatalysis. Using knowledge OSC morphology, an insertion strategy involved adding a suitable quantity guest acceptor (Y6‐O) to PM6 donor polymer BTP‐2F‐ThCl host small molecule system. Y6‐O leads tighter π–π packing, reduced domain size, improved purity, resulting in favorable morphology for...
Background: Patients with cancer often develop a prothrombotic state that can evolve into venous and arterial thrombosis, which is associated poor clinical outcomes. Glioblastoma multiforme (GBM) the most frequently but underlying causes of this are poorly defined. Objectives: We designed study to characterize expression coagulation factor X (FX) its alternatively spliced transcripts in glioblastoma tissues surgically removed from patients clonal cell lines. Methods: The F10 mRNA FX protein...
Mouse embryonic stem cells (ESCs) are genetically more stable than somatic cells, thereby preventing the passage of genomic abnormalities to their derivatives including germ cells. The underlying mechanisms, however, remain largely unclear. In this paper, we show that stemness factor Sall4 is required for activating critical Ataxia Telangiectasia Mutated (ATM)–dependent cellular responses DNA double-stranded breaks (DSBs) in mouse ESCs and confer resistance DSB-induced cytotoxicity. rapidly...
The neural precursor cell expressed developmentally downregulated protein 4 (NEDD4) plays a pivotal oncogenic role in various types of human cancers. However, the function NEDD4 bladder cancer has not been fully investigated. In present study, we aim to explore whether governs proliferation, apoptosis, migration, and invasion cells. Our results showed that downregulation suppressed proliferation Moreover, found inhibition significantly induced apoptosis. Furthermore, retarded migration...
The short-chain fatty acid metabolite acetyl-coenzyme A (acetyl-CoA) has emerged as a major signal transducer that can broadly affect cell fate and function, at least partly by influencing acetylation of key proteins. mechanism which acetyl-CoA regulates CD4+ T-cell determination remains poorly understood. Herein, we report acetate modulates glyceraldehyde-3-phosphate dehydrogenase (GAPDH) T helper 1 (Th1) differentiation altering levels. Our transcriptome profiling shows is robust positive...
The hydrophilicity and inherent flammability of cotton textiles severely limit their usage. To solve these drawbacks, a superhydrophobic flame-retardant (SFR) coating made chitosan (CH), ammonium polyphosphate (APP), TiO2-SiO2-HMDS composite was applied to fabric using simple layer-by-layer assembly dip-coating procedures. First, the alternately immersed in CH APP water dispersions, then form CH/APP@TiO2-SiO2-HMDS on surface. SEM, EDS, FTIR were used analyze surface morphology, element...
Introduction Chlorogenic acid (CGA) has been identified to possess salient anti-inflammatory, antioxidant, and anticancer attributes. However, its application is limited by instability low bioavailability. Liposomes have considered effective pharmaceutical delivery vehicles due their ability continuously release loaded drugs, improve drug stability, display good biocompatibility. They can be easily modified other small molecules acquire additional biological functions. In this study, we...
Epithelial-to-mesenchymal transition (EMT) has been linked to various human diseases including cancer. The underlying metabolic regulators, however, remain poorly understood. Here we show how the short-chain fatty acid acetate restrains EMT. Our findings indicate that is a potent regulator of