A5023824836- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Tryptophan and brain disorders
- Memory and Neural Mechanisms
- Neuroscience and Neural Engineering
- RNA and protein synthesis mechanisms
- Biochemical Analysis and Sensing Techniques
- Neurogenesis and neuroplasticity mechanisms
- Attention Deficit Hyperactivity Disorder
- Molecular Communication and Nanonetworks
- Neuroendocrine regulation and behavior
Charité - Universitätsmedizin Berlin
2019-2025
Max Delbrück Center
2019-2025
University of Würzburg
2011-2013
Kyushu University
2009
Brain serotonin (5-HT) is implicated in a wide range of functions from basic physiological mechanisms to complex behaviors, including neuropsychiatric conditions, as well developmental processes. Increasing evidence links 5-HT signaling alterations during development emotional dysregulation and psychopathology adult age. To further analyze the importance brain somatic function, more specifically differentiation specification serotonergic system itself, we generated mouse model with...
ORIGINAL RESEARCH article Front. Pharmacol., 02 August 2013Sec. Neuropharmacology https://doi.org/10.3389/fphar.2013.00097
Brain serotonin (5-hydroxytryptamine, 5-HT) system dysfunction is implicated in exaggerated fear responses triggering various anxiety-, stress-, and trauma-related disorders. However, the underlying mechanisms are not well understood. Here, we investigated impact of constitutively inactivated 5-HT synthesis on context-dependent learning extinction using tryptophan hydroxylase 2 (Tph2) knockout mice. Fear conditioning memory paradigms were combined with c-Fos imaging electrophysiological...
The dentate gyrus of the hippocampus is targeted by axons from serotonin raphe neurons, where neurotransmitter modulates adult neurogenesis and antidepressant action, mediates neurogenic effect running. Whether running-induced cell proliferation directly mediated remains unknown. Here, we took advantage Tph2-ChR2-YFP transgenic mice in which light-sensitive protein channelrhodopsin-2 (ChR2) specifically expressed tryptophan hydroxylase 2 (TPH2)-expressing neurons. We selectively activated...
Abstract Background The glutamate receptors (GluRs) play a vital role in the mediation of excitatory synaptic transmission central nervous system. To clarify evolutionary dynamics and mechanisms GluR genes lineage leading to humans, we determined complete sequences coding regions splice sites 26 chimpanzee genes. Results We found that all reading frames these reported humans were completely conserved chimpanzees, suggesting there no gross structural changes after their divergence from...
Optogenetics enables activation/silencing of specific neurons with unprecedented temporal and spatial resolution. The method, however, is prone to artefacts associated biophysics light used for illuminating opsin-expressing neurons. Here we employed Tph2-mhChR2-YFP transgenic mice, which express channelrhodopsin (ChR2) only in serotonergic the brain, investigate behavioral effects optogenetic stimulation Surprisingly, enhanced locomotion even ChR2-negative mice. Such unspecific are likely be...