A5011595052- Edible Oils Quality and Analysis
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Electrospun Nanofibers in Biomedical Applications
- Liver Disease Diagnosis and Treatment
- Wound Healing and Treatments
- Skin Protection and Aging
- Phytochemical and Pharmacological Studies
- Eicosanoids and Hypertension Pharmacology
- Atherosclerosis and Cardiovascular Diseases
- Natural product bioactivities and synthesis
- Liver physiology and pathology
- biodegradable polymer synthesis and properties
- Algal biology and biofuel production
- Drug-Induced Hepatotoxicity and Protection
- Garlic and Onion Studies
- Phytochemical compounds biological activities
- Free Radicals and Antioxidants
- Diabetic Foot Ulcer Assessment and Management
- Genomics, phytochemicals, and oxidative stress
- Cholesterol and Lipid Metabolism
University of Siena
2019-2022
University of Pisa
2019-2022
Inflammation of the adipose tissue plays an important role in development several chronic diseases associated with obesity. Polyphenols extra virgin olive oil (EVOO), such as secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles obesity-associated adipocyte inflammation, NF-κB pathway related sub-networks not been fully elucidated. Here, we investigated impact OC OA on activation expression molecules inflammatory dysmetabolic responses. To...
Extra-virgin olive oil (EVOO) polyphenols contribute to Mediterranean diet health-promoting properties. One of the most abundant secoiridoid present in EVOO, Oleacein (OA), demonstrated anticancer activity against several tumors. Nevertheless, its role melanoma has not still investigated. This study aimed at determining vitro antimelanoma OA and relative mechanism action. induced cell growth inhibition 501Mel cells with an IC50 low micromolar range concentrations. Moreover, concentration...
Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated anti-fibrotic and anti-inflammatory effects polyphenol oleocanthal (OC) extracted from extra virgin olive oil (EVOO) by in vitro/in vivo approach. The hepatic cell lines LX2 HepG2 were used as vitro models. mRNA expression pro-fibrogenic markers, namely alpha-smooth muscle actin (α-SMA), collagen type I alpha 1 chain (COL1A1), a panel...
The health benefits of extra-virgin olive oil (EVOO) are strictly linked to the presence phenolic compounds, which exhibit numerous nutraceutical properties. In EVOO, most important class compounds is represented by secoiridoids (oleacein and oleocanthal). EVOO constantly subjected degradation processes, including hydrolytic oxidative reactions that influence its composition. particular, determine transformation oleocanthal oleacein into corresponding phenyl-alcohols, tyrosol,...
Olive leaf extract (OLE) can be obtained as biowaste and is extensively used a food supplement an over-the-counter drug for its beneficial effects. New studies have investigated OLE concerning the role of oxidative stress in pathogenesis vascular disease. This vitro study aims to evaluate if extracted from Tuscan Olea europaea protects endothelial cells against generated by reactive oxygen species (ROS).OLE total polyphenols (TPs) were characterized Folin-Ciocalteu method. Endothelial grown...
Olive tree is a well-known source of polyphenols. We prepared an olive leaf extract (OLE) and characterized it via high performance liquid chromatography (HPLC) analysis. OLE was blended with different polyhydroxyalkanoates (PHAs), namely, poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) polyhydroxybutyrate/poly(hydroxyoctanoate-co-hydroxydecanoate) (PHB/PHOHD), to produce fiber meshes electrospinning: OLE/PHBV OLE/ respectively. An 80–90% (w/w%) release the main polyphenols from OLE/PHA...
Polyhydroxyalkanoates (PHAs) are a family of biopolyesters synthesized by various microorganisms. Due to their biocompatibility and biodegradation, PHAs have been proposed for biomedical applications, including tissue engineering scaffolds. Olive leaf extract (OLE) can be obtained from agri-food biowaste is source polyphenols with remarkable antioxidant properties. This study aimed at incorporating OLE inside poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) fibers via electrospinning obtain...