A5013014262- Cannabis and Cannabinoid Research
- Herbal Medicine Research Studies
- RNA Interference and Gene Delivery
- Asthma and respiratory diseases
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Pharmacological Receptor Mechanisms and Effects
- Respiratory and Cough-Related Research
- Extracellular vesicles in disease
- Advanced biosensing and bioanalysis techniques
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Neuropeptides and Animal Physiology
- Algal biology and biofuel production
- Computational Drug Discovery Methods
- Ginseng Biological Effects and Applications
- Adipokines, Inflammation, and Metabolic Diseases
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Chemical Synthesis and Analysis
- PARP inhibition in cancer therapy
- Phytochemistry and Biological Activities
- Liver Disease Diagnosis and Treatment
University of Pisa
2016-2025
Ben-Gurion University of the Negev
2023
Istituto di Farmacologia Traslazionale
2014
University of Modena and Reggio Emilia
2012
University of Florence
2009
Istituto di Chimica Biomolecolare
2009
National Research Council
2009
This study explores the mixotrophic cultivation of Limnospira platensis using dairy byproducts, specifically scotta whey (SW), buttermilk wastewater (BMW), and (DWW), to promote biomass production enhance composition bioactive compounds. By assessing various concentrations (1%, 2%, 4% v v−1) these byproducts in a modified growth medium, this aims evaluate their effect on L. growth, phycocyanin (C-PC) content, fatty acid methyl ester (FAME) profiles. The results show that optimal was achieved...
Inflammation of the adipose tissue plays an important role in development several chronic diseases associated with obesity. Polyphenols extra virgin olive oil (EVOO), such as secoiridoids oleocanthal (OC) and oleacein (OA), have many nutraceutical proprieties. However, their roles obesity-associated adipocyte inflammation, NF-κB pathway related sub-networks not been fully elucidated. Here, we investigated impact OC OA on activation expression molecules inflammatory dysmetabolic responses. To...
Sirtuin 1 (SIRT1) enzyme plays a pivotal role in the regulation of many physiological functions. In particular, it is implicated ageing-related diseases, such as cardiac hypertrophy, myocardial infarct, and endothelial dysfunction; moreover, its expression decreases with age. Therefore, an effective strategy to extend lifespan improve cardiovascular function enhancement expression/activity SIRT1 exogenous agents. The Citrus flavonoid naringenin (NAR) presents structural similarity natural...
Arthrospira platensis, commonly known as Spirulina, is a photosynthetic filamentous cyanobacterium (blue–green microalga) that has been utilized food source since ancient times. More recently, it gained significant popularity dietary supplement due to its rich content of micro- and macro-nutrients. Of particular interest water soluble phycobiliprotein derived from Spirulina phycocyanin C (C-PC), which stands out the most abundant protein in this cyanobacterium. C-PC fluorescent protein, with...
Oleocanthal is one of the phenolic compounds extra virgin olive oil with important anti-inflammatory properties. Although its potential anticancer activity has been reported, only limited evidence provided in cutaneous malignant melanoma. The present study aimed at investigating selective vitro antiproliferative oleocanthal against human melanoma cells. Since not commercially available, it was obtained as a pure standard by direct extraction and purification from oil. Cell viability...
Background and purpose Apigenin can exert beneficial actions in the prevention of obesity. However, its putative action on obesity-associated bowel motor dysfunctions is unknown. This study examined effects apigenin colonic inflammatory abnormalities a mouse model diet-induced Experimental approach Male C57BL/6J mice were fed with standard diet (SD) or high-fat (HFD). SD HFD treated (10 mg/Kg/day). After 8 weeks, body epididymal fat weight, as well cholesterol, triglycerides glucose levels...
For topical treatment of skin cancer, the design pH-responsive nanocarriers able to selectively release drug in tumor acidic microenvironment represents a reliable option for targeted delivery. In this context, series newly synthesized surface-active fatty acid-protic ionic liquids (FA-PILs), based on tetramethylguanidinium cation and different natural hydrophobic acid carboxylates, have been investigated with aim developing pH-sensitive nanostructured delivery system cutaneous...
Chronic inflammation of the adipose tissue (AT) is a major contributor to obesity-associated cardiometabolic complications. The olive oil polyphenol hydroxytyrosol (HT) contributes Mediterranean diet benefits through mechanisms still partially unknown. We investigated HT (1 and 10 μmol/L) effects on gene expression (mRNA microRNA) related induced by ng/mL tumor necrosis factor (TNF)-α in human Simpson–Golabi–Behmel Syndrome (SGBS) adipocytes. At real-time PCR, significantly inhibited...
Diet has a strong influence on many physiological processes, which in turn have important implications variety of pathological conditions. In this respect, microRNAs (miRNAs), class small non-coding RNAs playing relevant epigenetic role controlling gene expression, may represent mediators between the dietary intake and healthy status. Despite great advances field nutri-epigenomics, it remains unclear how miRNA expression is modulated by diet and, specifically, specific nutrients. We...
Purpose Luteolin exerts beneficial effects against obesity-associated comorbidities, although its influence on vascular dysfunction remains undetermined. We examined the of luteolin endothelial in a mouse model diet-induced obesity. Methods Standard diet (SD) or high-fat (HFD)-fed mice were treated daily with intragastrically. After 8 weeks, body and epididymal fat weight, as well blood cholesterol, glucose triglycerides evaluated. Endothelium-dependent relaxations resistance mesenteric...
Melanoma is a devastating disease with few therapeutic options in the advanced stage and urgent need of reliable biomarkers for early detection. In this context, circulating microRNAs are raising great interest as diagnostic biomarkers. We analyzed expression profiles 21 selected plasma samples from melanoma patients healthy donors to identify potential Data analysis was performed using global mean normalization NormFinder algorithm. Linear regression followed by receiver operating...
Extra-virgin olive oil (EVOO) polyphenols contribute to Mediterranean diet health-promoting properties. One of the most abundant secoiridoid present in EVOO, Oleacein (OA), demonstrated anticancer activity against several tumors. Nevertheless, its role melanoma has not still investigated. This study aimed at determining vitro antimelanoma OA and relative mechanism action. induced cell growth inhibition 501Mel cells with an IC50 low micromolar range concentrations. Moreover, concentration...
Liver fibrosis, which is the outcome of wound-healing response to chronic liver damage, represents an unmet clinical need. This study evaluated anti-fibrotic and anti-inflammatory effects polyphenol oleocanthal (OC) extracted from extra virgin olive oil (EVOO) by in vitro/in vivo approach. The hepatic cell lines LX2 HepG2 were used as vitro models. mRNA expression pro-fibrogenic markers, namely alpha-smooth muscle actin (α-SMA), collagen type I alpha 1 chain (COL1A1), a panel...
The design of dualsteric/bitopic agents as single chemical entities able to simultaneously interact with both the orthosteric and an allosteric binding site represents a novel approach in medicinal chemistry. Biased could enhance certain signaling pathways while diminishing others that cause unwanted side effects. We have designed, synthesized, functionally characterized first CB2R heterobivalent bitopic ligands. In contrast parent compound, our ligands selectively target versus CB1R show...
Liver fibrosis is the result of a chronic pathological condition caused by activation hepatic stellate cells (HSCs), which induces excessive deposition extracellular matrix. Fibrogenesis sustained an exaggerated production reactive oxidative species (ROS) NADPH oxidases (NOXs), are overactivated in inflammation. In this study, we investigated antifibrotic properties two phenolic compounds natural origin, tyrosol (Tyr) and hydroxytyrosol (HTyr), known for their antioxidant anti-inflammatory...
holds promise for biotechnological applications due to its rapid growth and ability produce valuable bioactive compounds like phycocyanin (PC). This study explores the impact of salinity brewery wastewater (BWW) on mixotrophic cultivation