A5000205232- Advanced Drug Delivery Systems
- Ocular Surface and Contact Lens
- Advancements in Transdermal Drug Delivery
- Corneal Surgery and Treatments
- Nail Diseases and Treatments
- Dermatology and Skin Diseases
- Skin Protection and Aging
- Drug Solubulity and Delivery Systems
- Glaucoma and retinal disorders
- Nanoparticle-Based Drug Delivery
- Surfactants and Colloidal Systems
- Contact Dermatitis and Allergies
- Intraocular Surgery and Lenses
- Photochromic and Fluorescence Chemistry
- Herpesvirus Infections and Treatments
- Proteoglycans and glycosaminoglycans research
- Antibiotics Pharmacokinetics and Efficacy
- Bee Products Chemical Analysis
- Systemic Lupus Erythematosus Research
- Corneal surgery and disorders
- Pharmacological Effects of Natural Compounds
- Polysaccharides and Plant Cell Walls
- Animal testing and alternatives
- Glycosylation and Glycoproteins Research
- Ocular Infections and Treatments
University of Pisa
2015-2025
Background/Objectives: Melanoma is a pathology that affects large part of the population, and currently available therapies have many limitations, including selective targeting site action. This study explores development curcumin (CUR)-loaded nanostructured delivery systems for topical melanoma treatment, addressing CUR’s limitations in bioavailability, solubility, stability. Methods: Binary surfactant mixtures Vitamin E-TPGS (TPGS) Kolliphor ELP (ELP) were selected to form stable micelles...
Sunscreens are the most common products used for skin protection against harmful effects of ultraviolet radiation. However, as frequent application is recommended, use large amount sunscreens could reflect in possible systemic absorption and since these preparations often applied on areas, even low penetration rates can cause a significant sunscreen to enter body. An ideal should have high substantivity neither penetrate viable epidermis, dermis circulation, nor hair follicle. The research...
For topical treatment of skin cancer, the design pH-responsive nanocarriers able to selectively release drug in tumor acidic microenvironment represents a reliable option for targeted delivery. In this context, series newly synthesized surface-active fatty acid-protic ionic liquids (FA-PILs), based on tetramethylguanidinium cation and different natural hydrophobic acid carboxylates, have been investigated with aim developing pH-sensitive nanostructured delivery system cutaneous...
The present paper is concerned with the development of a simple dry eye model in rabbit, induced by daily repeated instillations 1.0% atropine sulphate. evolution syndrome animals was assessed Schirmer I test and examination cornea after fluorescein staining. produced rapidly some typical symptoms could be satisfactorily used for preliminary assessment protective activity polymeric tear substitutes. These were based on hydroxypropylmethylcellulose, sodium hyaluronate, polyacrylate or...
The physiological protective mechanisms of the eye reduce bioavailability topically administered drugs above all for those with high molecular weight and /or lipophilic characteristics, such as Cyclosporine A (CyA). combined strategy based on association nanomicelles mucoadhesive polymer seems promising since a limited number commercial products containing CyA have been recently approved. scope this investigation was design Assembling Surfactants-Mucoadhesive Polymer Nanomicelles...
A combination of in situ gelling systems and a loaded drug self-assembling nanomicellar carrier was chosen this study as new potential Ocular Drug Delivery System (ODDS) for Cyclosporine-A (CyA), poorly water-soluble drug. Two non-ionic surfactants (d-α-tocopherol polyethylene glycol succinate, VitE-TPGS polyoxyl 40 hydrogenated castor oil, RH-40) were used to produce the nanomicelles. The physical–chemical characterization nanomicelles terms CyA entrapment (EE%) loading efficiency (LE%),...
Commercial antimycotic nail lacquers are commonly based on water-insoluble resins. The present study was aimed at evaluating a novel, experimental lacquer (P-3051, Polichem SA, Lugano, Switzerland) the water-soluble film-forming agent hydroxypropyl chitosan (HPCH). in vitro permeation of ciclopirox (CPX) from P-3051 and commercial, vinyl resin (Penlac, Aventis Pharma), investigated using thin membranes obtained bovine hooves, an accepted model for human nails. Similar CPX fluxes steady state...
Topical therapy has recently been proposed for treating onychomycosis and other nail disturbances. However, the clinical outcome may be limited by difficulty of active ingredients effectively penetrating plate. Bovine hoof membranes have widely used to predict in vitro efficacy drug products diseases. Many studies compared bovine hooves with human healthy nails, considering difference between unhealthy nails negligible.To validate slices as a model investigating transungual...
Context: Mucoadhesive nanoparticles were compared with non-aggregated constituent polymers for effect on pre-corneal residence of dexamethasone phosphate (DP) or met-enkephalin (ME), administered by eye-drops to rabbits.Objective: Deepening the knowledge ophthalmic nanoparticulate systems in terms ability prolong residence.Materials and methods: Medicated resulted from gelation quaternary ammonium–chitosan conjugate its thiolated derivative hyaluronan presence drug. Particles analyzed light...
Background/Objectives: Curcumin (CUR) is a natural compound with notable antitumor properties but faces limitations in topical applications due to poor aqueous solubility, instability, and insufficient skin penetration. To overcome these challenges, nanomicellar formulation (TPGS30ELP15) was developed enhance CUR stability, This study aimed at evaluating the permeation retention of when delivered through nanomicelles alone or combined thermosensitive hydrogel for potential melanoma therapy....