A5100612517- Anesthesia and Neurotoxicity Research
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Infant Development and Preterm Care
- Metal complexes synthesis and properties
- Blood groups and transfusion
- Trauma and Emergency Care Studies
- Hepatitis B Virus Studies
- Salivary Gland Disorders and Functions
- Adolescent and Pediatric Healthcare
- Ferroptosis and cancer prognosis
- Genetic Associations and Epidemiology
- Pregnancy and preeclampsia studies
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Abdominal Trauma and Injuries
- Magnetism in coordination complexes
- Ergonomics and Musculoskeletal Disorders
- Nonlinear Optical Materials Research
- Spinal Fractures and Fixation Techniques
- Wound Healing and Treatments
- Suicide and Self-Harm Studies
- Folate and B Vitamins Research
- Monoclonal and Polyclonal Antibodies Research
- Parathyroid Disorders and Treatments
Qingdao University of Science and Technology
2022-2025
Hebei University
2023-2025
Zhejiang Chinese Medical University
2021-2024
Central South University
2010-2024
University of Michigan–Flint
2012-2024
Zhongda Hospital Southeast University
2024
Hainan Medical University
2024
Hainan General Hospital
2024
Second Xiangya Hospital of Central South University
2023-2024
Karolinska Institutet
2022-2024
Abstract Background Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder that accompanied by muscle weakness and atrophy, typically resulting in death within 3–5 years from the disease occurrence. Though cause of ALS remains unclear, increasing evidence has suggested inflammation involved pathogenesis ALS. Thus, we performed two-sample Mendelian randomization (MR) analyses to estimate associations circulating levels cytokines growth factors with risk Methods Genetic...
Abstract Background Growing evidence has suggested that gut microbiota is closely related to the risk of irritable bowel syndrome (IBS), but whether there a causal effect remains unknown. We adopted Mendelian randomization (MR) approach evaluate potential relationships between and IBS. Methods Genetic instrumental variables for were identified from genome-wide association study (GWAS) 18,340 participants. Summary statistics IBS drawn GWAS including 53,400 cases 433,201 controls. used...
Development of new methods to screen early gastric cancer patients has great clinical requirement. Ten amino acids in human saliva are identified as small metabolite biomarkers distinguish and advanced from healthy persons by using high performance liquid chromatography-mass spectrometry (HPLC-MS). Then, surface enhanced Raman scattering (SERS) sensors based on graphene oxide nanoscrolls wrapped with gold nanoparticles developed detect ten saliva. The distinctive facilely prepared via...
Alzheimer's disease (AD) is the most serious neurodegenerative worldwide and characterized by progressive cognitive impairment multiple neurological changes, including neuronal loss in brain. However, there are no available drugs to delay or cure this disease. Consequently, replacement therapy may be a strategy treat AD. Osthole (Ost), natural coumarin derivative, crosses blood-brain barrier exerts strong neuroprotective effects against AD vitro vivo. Recently, microRNAs (miRNAs) have...
Background Evidence from observational studies on the association of folate and vitamin B 12 with autoimmune diseases are conflicting. Objective We aimed to investigate relationship using Mendelian randomization (MR). Materials methods selected single-nucleotide polymorphisms associated at genome-wide significance level. Summary-level data for four common (vitiligo, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus) were obtained large-scale studies, a sample...
In this study, we will report on the synthesis and application of efficient botanical agrochemicals from turpentine for sustainable crop protection. Two series derived secondary amines were synthesized identified by FT-IR, 1H NMR, 13C HRMS. The herbicidal activities against Echinochloa crus-galli evaluated. potential toxicity compounds was tested MTT cytotoxicity analysis. effect structure corresponding Schiff base their investigated quantitative structure-activity relationship (QSAR) study....
Abstract Frailty causes emerging global health burden due to its high prevalence and mortality. In this study, we used Mendelian randomization (MR) approach examine the potential causal relationship between smoking frailty in ageing. Using inverse-variance weighted (IVW) method, genetically predicted initiation was associated with an increased risk of ageing (odd ratio (OR) 1.23, 95% confidence interval (CI) 1.19–1.27, P = 3.21 × 10 –39 ). Similarly, per year increase age regular a 25%...
Abstract Purpose It is not known whether the elevated suicide risk in certain occupations, such as health care professionals, partly attributable to a selection of individuals with prior vulnerability. We aimed determine and self-harm already students entering different university programs. Methods used national registers identify 621,218 Swedish residents aged 18–39 years registration for program 1993–2013. Outcomes were within three years. applied logistic regression analyses calculate...
Abstract Background and Aims It is demonstrated that lipid metabolism disorders are associated with the reproductive performances of assisted technology. However, it little known whether hyperlipidemia endometrial receptivity pregnancy outcomes patients undergoing frozen‐thawed embryo transfer (FET). Methods This was a retrospective analysis involving 554 infertile women FET. The were divided into group ( n = 224) control 320) based on levels serum lipids. clinical laboratory indexes between...
The diagnostic criteria of bipolar disorder (BD) have changed over time. To test if these changes are reflected in the polygenic profile BD, we studied association between first BD diagnosis year (during 1972-2016) and scores (PGS) for psychiatric disorders patients (N = 3,818). We found significant associations PGS depression, attention deficit hyperactivity (ADHD). remained largely stable time type 1, while were observed 2. These findings bear significance not only genetic research but...
Green pepper, a commonly cultivated vegetable, often suffers from fruit rot caused by Alternaria alternata, which reduces its quality and shelf life. In this study, the antifungal activity mechanism of patchouli alcohol (PA), was isolated Pogostemon cablin essential oil, against A. alternata during storage green peppers, were investigated. PA effectively inhibited growth in vitro vivo assays, reduced lesion areas, extended life peppers. Scanning transmission electron microscopy revealed that...
Ginseng (Panax ginseng C.A. Meyer) is one of the most widely used herbal medicines worldwide. The present study evaluated neuroprotective effects protein (GP) and its possible mechanisms in a cellular animal model AD. results demonstrated that GP (10-100 µg/mL) significantly improved survival rate neurons reduced cells' apoptosis mRNA expression caspase-3 Bax/Bcl-2. In addition, (0.1 g/kg) shortened escape latency, prolonged crossing times percentage residence time; level Aβ1-42 p-tau,...
A correlation between mental illness and systemic rheumatoid arthritis (RA) has been observed in several prior investigations. However, little is known about the causative relationship them. The present study aimed to systematically investigate potential association genetically determined RA. Two-sample bidirectional Mendelian randomization (MR) analysis was performed using publicly released genome-wide studies (GWAS). We selected independent genetic variants associated with four illnesses...
Insulin resistance has been implicated in the pathogenesis of children born small for gestational age (SGA) with catch-up growth (CUG). Adipose tissue macrophages (ATMs) regulate insulin by secreting exosomes containing microRNA (miRNA) cargo; however, their pathogenic roles and molecular mechanism are not fully understood. This study aimed to investigate role miR-210-5p rats SGA CUG resistance.The dietary needs pregnant were restricted ensure birth rats. Transmission electron microscopy...
The present study investigates the role of Secreted Frizzled‑Related Protein 2 (SFRP2) in trophoblast cells, a key factor preeclampsia (PE) progression. Elevated levels 1/3/4/5 (SFRP1/3/4/5) are associated with PE, but SFRP2 is unclear. We analyzed expression PE placental tissue using GSE10588 dataset and overexpressed JEG‑3 cells via lentiviral transfection. viability, migration, apoptosis, proliferation SFRP2‑overexpressing were assessed Cell Counting Kit‑8, Transwell assays, flow...
Modifiable factors were found to be associated with the risk of irritable bowel syndrome (IBS) in observational studies, but whether these associations are causal is uncertain. We conducted a Mendelian randomization (MR) study systematically explore modifiable IBS.
In order to explore novel antifungal lead compounds from plant essential oil, thirty-two pinonic acid derivatives containing thiourea groups were designed and synthesized using α-pinene as a raw material. One of these compound
Glioblastomas (GBMs) are the most aggressive type of glial brain tumors. Despite treatment with surgery and chemoradiation, GBMs invariably relapse tumors progressive. Controversy remains on optimal patients recurrent GBMs. Data from previous trials have suggested that addition bevacizumab (BEV) to lomustine (CCNU) might improve overall survival (OS) as compared monotherapies. The aim this study was compare efficacy BEV in CCNU versus single-agent therapy GBM.Electronic databases were...
Machine learning techniques are widely used for the diagnosis of cancers.In this study, we proposed a classification and prediction system gastric cancer based on saliva samples.Gastric (GC) is classified into early (EGC) advanced (AGC).The GC at an stage will improve survival rate.Computer-aided diagnostic (CAD) systems can assist radiologists in EGC.220 samples were collected from non-cancerous cancerous persons analyzed using high-performance liquid chromatography-mass spectrometry...
Abstract Small interfering RNAs (siRNAs) directed against poliovirus (PV) and other viruses effectively inhibit viral replication have been developed as antiviral agents. Here, we demonstrate that a specific siRNA targeting the region between nucleotides 100–125 (siRNA-100) from 5′-untranslated (5′-UTR) of PV plays critical role in inhibiting replication. Our data siRNA-100 treatment can greatly reduce titers, resulting up-regulation host microRNA-7 (miR-7), which turn, leads to enhance...