In this study, two novel Schiff base ligands (L1 and L2) derived from condensation of methyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate 2-amino-6-phenyl-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylate, both starting matter with 5-bromo-salicylaldehyde, their Zn(II) Ni(II) metal complexes have been prepared using a molar ratio ligand:metal as 1:1 except the Ru(II) 1:0.5. The structures obtained were characterized by elemental analysis, FT-IR, 1H NMR, 13C UV–vis,...

In this work, novel vic-dioxime ligand (LH2 ) containing bound to the N4 -oxime core moiety and its complexes with Cu(II), Ni(II), Ti(IV), VO(IV), Zn(II) salts have been studied. The structure of were successfully synthesized characterized using NMR (1 H 13 C), LC/MS/MS spectrometer, FT-IR UV/VIS spectroscopy, melting point, magnetic susceptibility measurements. Vic-dioxime (1) metal ([Cu(LH)2 ] (2), [Ni(LH)2 (3), [Ti(LH)2 ]Cl2 (4), [VO(LH)2 (5), [Zn(LH)2 (6), respectively) tested for them...

The blocking of nitric oxide synthase (NOS) activity may cause vasoconstriction with formation reactive oxygen species. Propolis is a natural product collected from plants by honeybees. has biological and pharmacological properties.This study was designed to investigate the effects propolis on catalase (CAT) activity, (NO) malondialdehyde (MDA) levels in liver tissues NOS inhibited rats Nω-Nitro-L-arginine methyl ester (L-NAME).Rats were given inhibitor (L-NAME, 40 mg/kg, intraperitoneally)...

ABSTRACT This research focused on synthesizing a Schiff base (L) and its Co(II) Pd(II) complexes under appropriate conditions to contribute enhancing antioxidant activity. The ligand was synthesized by reacting methyl 2‐amino‐4‐ethyl‐5‐methylthiophene‐3‐carboxylate with 5‐bromo‐2‐hydroxybenzaldehyde. Various analytical techniques were employed characterize the resulting complexes, including microanalysis, 1 H 13 C NMR spectroscopy, FTIR, electronic spectra, mass spectrometry, magnetic...

Background: Fe(II) and Zn(II) complex series have been synthesized from Schiff base ligands derived furan-2-carbaldehyde thiophene-2-carbaldehyde. Elemental, infrared, ultraviolet- visible, NMR thermal analysis, also mass spectroscopy magnetic susceptibility measurements were performed to explain the structures of these their metal complexes. The formulas based on analytical, spectral, studies, complexes can be demonstrated as [M(L1)2](H2O)n, [M(L2)2](H2O)n, where M = Fe(II). An octahedral...

Background: Free radicals lead to destruction in various organs of the organism. The improper use antibiotics increases formation free and causes oxidative stress. Objective: In this study, it was aimed determine effects gentamicin, amoxicillin, cefazolin on mouse heart. Methods: 20 male mice were divided into 4 groups (1st control, 2nd 3rd cefazolin, 4th gentamicin groups). experimental administered intraperitoneally at a dose 100 mg / kg for 6 days. control group received normal saline...

This study reports the synthesis of Co(II), Fe(II), Pd(II) and Ru(II) complexes with Schiff base obtained by condensation 2-amino-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate salicylaldehyde. The characterization ligand its was arranged studied FT-IR, UV-Vis., 1H 13C NMR, microanalyses (C, H, N, S), X-ray diffraction (XRD) analysis, magnetic susceptibility, mass spectra thermogravimetry analysis (TGA) further screened for antimicrobial, antioxidant antiradical activities....

Bitkilerin iyilestirici etkilerinin icerdikleri bilesenlerden kaynaklandigi bilinmektedir. Bugunun bilim dunyasinda, yeni terapotik ajanlarin gelistirilmesi ve kesfinde oldugu gibi bitki icerikleri biyolojik aktiviteleri uzerine calismalar cok populerdir. Bu calismada, cesitli hastaliklarin tedavisi aktif madde dizayninda literatur icin degerli data elde etmek amaciyla, Lallementia canescens (L. canescens) peltata peltata)’nin arastirildi. Henuz yararlari tam aydinlatilmamis olan bu bitkiler...

Moderate effects of some plants with proven biological properties in the treatment various diseases have increased importance them and interest alternative medicine. The members Lamiaceae family are one widely used medicine agriculture due to their metabolite content. In order gain valuable data for new studies, Scutellaria albida subsp. Candensest a member was collected from height 1500 meters Bitlis province Turkey. Ethanol (EtOH) extract prepared by using aerial parts plant all stages...

Lamiaceae familyasının üyeleri içerdikleri sekonder metabolitler sayesinde geleneksel tıpta ve tarımda yaygın bir şekilde kullanılmaktadırlar. Bu çalışmada, Bitlis İlinde toplanan Nepeta transcaucasica Grossh. (kaf pisikotu) bitkisinden elde edilen etanol ekstraktının fenolik madde içeriği HPLC ile belirlenerek, antimikrobiyal, antioksidan DNA koruyucu aktiviteleri araştırıldı. Ekstraktın en fazla apigenin vanillin içerdiği belirlendi. Antimikrobiyal aktivite sonuçlarına göre genel olarak...

In this study, Ranunculus cornutus DC. (Evlimemedotu) content analysis and some biological activities were investigated. For purpose, methanol water extracts of the plant taken their phenolic analyzes determined by LC-MS-MS. Total antioxidant method, FRAP, CUPRAC, iron chelation DPPH ABTS methods used for studies. According to LC-MS results, maximum was 3261.43 µg/L, vanillic acid 1217.70 µg/L ferulic 769.40 µg/L. it that exhibited lower activity than standard antioxidants. It can be said...

The Onosma genus has been used as a treatment among the public for long time. In this study, content analysis and some biological activities of plant O. Alborosea Fisch. & C.A.Mey. ssp. (O. alborosea) in traditional medicine our country were investigated. For purpose, methanol water extracts taken total phenolic substance amount each extract was determined by HPLC device. FRAP, CUPRAC reduction methods DPPH, ABTS radical scavenging to determine antioxidant activities. According results...