A5037657698- Neural dynamics and brain function
- Neuroscience and Music Perception
- Functional Brain Connectivity Studies
- Neural and Behavioral Psychology Studies
- EEG and Brain-Computer Interfaces
- Transcranial Magnetic Stimulation Studies
- Multisensory perception and integration
- Visual perception and processing mechanisms
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Receptor Mechanisms and Signaling
- Neuroscience and Neural Engineering
- Face Recognition and Perception
- Schizophrenia research and treatment
- Amino Acid Enzymes and Metabolism
- Mental Health Research Topics
- Hearing Loss and Rehabilitation
- Analog and Mixed-Signal Circuit Design
- Neuroendocrine regulation and behavior
- Action Observation and Synchronization
- Advanced Data Processing Techniques
- Diverse Music Education Insights
- Motor Control and Adaptation
- Migraine and Headache Studies
- Anesthesia and Sedative Agents
Nathan Kline Institute for Psychiatric Research
2015-2025
New York State Psychiatric Institute
2019-2024
Columbia University
2015-2024
Columbia University Irving Medical Center
2017-2024
New York Psychoanalytic Society and Institute
2017-2023
Columbia College
2018
Royal College of Physicians
2018
City College of New York
2008-2011
St. Vincent's Hospital
2008
St Vincent's Hospital
2008
Intracranial recordings from three human subjects provide the first direct electrophysiological evidence for audio-visual multisensory processing in superior parietal lobule (SPL). Auditory and visual sensory inputs project to same highly localized region of cortex with auditory arriving considerably earlier (30 ms) than (75 ms). Multisensory integration processes this were assessed by comparing response simultaneous stimulation algebraic sum responses constituent unisensory stimulus...
Visual object-recognition is thought to involve activation of a distributed network cortical regions, nodes which include the lateral prefrontal cortex, so-called occipital complex (LOC), and hippocampal formation. It has been proposed that long-range oscillatory synchronization major mode coordinating such network. Here, intracranial recordings were made from three humans as they performed challenging visual task required them identify barely recognizable fragmented line-drawings common...
Oscillatory entrainment mechanisms are invoked during attentional processing of rhythmically occurring stimuli, whereby their phase alignment regulates the excitability state neurons coding for anticipated inputs. These have been examined in delta band (1–3 Hz), where frequency matches stimulation rate. Here, we investigated subdelta rhythmic stimulation, recording from intracranial electrodes over human auditory cortex an intersensory audiovisual task. Audiovisual stimuli were presented at...
Schizophrenia is characterized by widespread cognitive deficits that reflect distributed dysfunction across multiple cortical regions. Here the authors examined relationship between lower- and higher-level within auditory domain using event-related brain potentials mismatch negativity (MMN) P300.Event-related were obtained from 50 schizophrenia patients 21 healthy subjects in two conditions: a standard condition employing fixed differences tones pitch deviants novel individualized matched to...
Perceptual closure is the ability to identify objects based on partial information and depends function of a distributed network brain regions that include dorsal ventral visual streams, prefrontal cortex (PFC), hippocampus.To evaluate network-level interactions during perceptual in schizophrenia using parallel event-related potential (ERP), functional magnetic resonance imaging (fMRI), neuropsychological assessment.Case-control study.Inpatient outpatient facilities associated with Nathan...
The imperative to establish so-called endophenotypes-quantifiable measures of risk for neurological dysfunction-is a growing focus research in schizophrenia. Electrophysiological markers sensory processing, observable human event-related potentials, hold great promise this regard, lying closer underlying physiology than descriptive clinical diagnostic tests.Early visual processing deficits, as measured by clear amplitude reductions the occipital P1 component potential, have been repeatedly...
Deficits in auditory emotion recognition (AER) are a core feature of schizophrenia and key component social cognitive impairment. AER deficits tied behaviorally to impaired ability interpret tonal (“prosodic”) features speech that normally convey emotion, such as modulations base pitch (F0M) variability (F0SD). These can be recreated using synthetic frequency modulated (FM) tones mimic the prosodic contours specific emotional stimuli. The present study investigates neural mechanisms...
Perceptual organization, which refers to the ability integrate fragments of stimuli form a representation whole edge, part, or object, is impaired in schizophrenia. A contour integration paradigm, involving detection set Gabor patches forming an oval pointing right left embedded field randomly oriented Gabors, has been developed for use clinical trials The purpose present study was assess contributions early and later stages processing deficits integration, as well develop event-related...
Patients with schizophrenia show response inhibition deficits equal to or greater than those seen in impulse-control disorders, and these contribute poor outcome. However, little is known about the circuit abnormalities underlying this impairment. To address this, we examined stop signal task performance 21 patients healthy controls using event related potential (ERP) resting state functional connectivity. showed prolonged reaction time (SSRT) reduced N1, N2, P3 amplitudes compared controls....
A failure of adaptive inference—misinterpreting available sensory information for appropriate perception and action—is at the heart clinical manifestations schizophrenia, implicating key subcortical structures in brain including hippocampus. We used high-resolution, three-dimensional (3D) fractal geometry analysis to study subtle potentially biologically relevant structural alterations (in protrusions, gyri indentations, sulci) gray matter (GM) patients with schizophrenia relative healthy...
Abstract Background Amyloid deposition is a primary predictor of Alzheimer’s disease (AD) and related neurodegenerative disorders. Retinal changes involving the structure function ganglion cell layer are increasingly documented in both established prodromal AD. Visual event-related potentials (vERP) sensitive to dysfunction magno- parvocellular visual systems, which originate within retinal layer. The present study evaluates vERP as amyloid aging, mild cognitive impairment (MCI). Methods...