A5008479872- Schizophrenia research and treatment
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neuroscience and Music Perception
- Treatment of Major Depression
- Functional Brain Connectivity Studies
- Amino Acid Enzymes and Metabolism
- Neural dynamics and brain function
- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Advanced MRI Techniques and Applications
- Mental Health and Psychiatry
- Health Systems, Economic Evaluations, Quality of Life
- Hearing Loss and Rehabilitation
- Neural and Behavioral Psychology Studies
- Mental Health Research Topics
- Sleep and Wakefulness Research
- Neuroendocrine regulation and behavior
- Sleep and related disorders
- Stress Responses and Cortisol
- Parkinson's Disease Mechanisms and Treatments
- Transcranial Magnetic Stimulation Studies
- Cardiac electrophysiology and arrhythmias
Columbia University
2016-2025
New York State Psychiatric Institute
2014-2025
Nathan Kline Institute for Psychiatric Research
2016-2025
New York Psychoanalytic Society and Institute
2014-2025
New York University
2009-2023
Columbia University Irving Medical Center
2016-2022
The Graduate Center, CUNY
2017
City University of New York
2017
Icahn School of Medicine at Mount Sinai
2017
Cornell University
2016
Objective: Schizophrenia is associated with deficits in the ability to perceive emotion based on tone of voice. The basis for this deficit remains unclear, however, and relevant assessment batteries remain limited. authors evaluated performance schizophrenia a novel voice recognition battery well-characterized physical features, relative impairments more general emotional cognitive functioning. Method: studied primary sample 92 patients 73 comparison subjects. Stimuli were characterized...
Schizophrenia is associated with deficits in cortical plasticity that affect sensory brain regions and lead to impaired cognitive performance. Here we examined underlying neural mechanisms of auditory using combined behavioural neurophysiological assessment, along neuropharmacological manipulation targeted at the N-methyl-D-aspartate type glutamate receptor (NMDAR). Cortical was assessed a cohort 40 schizophrenia/schizoaffective patients relative 42 healthy control subjects fixed reference...
Despite strong theoretical rationale and preclinical evidence, several glutamate-targeted treatments for schizophrenia have failed in recent pivotal trials, prompting questions as to target validity, compound inadequacy, or lack of engagement. A key limitation glutamate-based treatment development is the functional target-engagement biomarkers translation between early-stage clinical studies. We evaluated utility 3 potential biomarkers-ketamine-evoked changes magnetic imaging (fMRI) blood...
Deficits in auditory emotion recognition (AER) are a core feature of schizophrenia and key component social cognitive impairment. AER deficits tied behaviorally to impaired ability interpret tonal (“prosodic”) features speech that normally convey emotion, such as modulations base pitch (F0M) variability (F0SD). These can be recreated using synthetic frequency modulated (FM) tones mimic the prosodic contours specific emotional stimuli. The present study investigates neural mechanisms...
Abstract Background Schizophrenia is a disabling disorder that profoundly affects functioning and quality of life. While available antipsychotics have improved outcomes for patients with schizophrenia, they are relatively ineffective negative cognitive symptoms associated range troublesome side effects. A significant unmet medical need more effective better-tolerated therapies remains. Methods roundtable consisting 4 experts in the treatment schizophrenia convened to discuss current...